Patents by Inventor Andre Buzas

Andre Buzas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4983614
    Abstract: The invention relates to benzhydryloxyethylpiperidine derivatives corresponding to one of the formulae below: ##STR1## in which: R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which are identical or different, represent a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, an aryloxy group or the trifluoromethyl group,R represents hydrogen, a cation, an alkyl group, an aryl group or an arylalkyl group, andn is equal to 0 or 1, and their pharmaceutically acceptable salts, useful in the treatment of spasmodic states and allergies.
    Type: Grant
    Filed: December 28, 1988
    Date of Patent: January 8, 1991
    Assignee: Les Laboratoires Meram
    Inventors: Andre Buzas, Jean-Yves Merour, Roland Ollivier
  • Patent number: 4908365
    Abstract: The present invention relates to benzhydryloxyethylpiperazine derivatives of the formula: ##STR1## It also relates to processes for the preparation of the said derivatives and pharmaceutical compositions in which they are present. The said derivatives have an antihistaminic activity without a sedative component.
    Type: Grant
    Filed: July 7, 1987
    Date of Patent: March 13, 1990
    Inventors: Andre Buzas, Jean-Yves Merour, Roland Ollivier
  • Patent number: 4882331
    Abstract: The invention relates to 1-[(1,1-diphenyl)-1-alkenyl]piperazine derivatives corresponding to general formula I: ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5, which are identical or different, represent a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkenyl group, a lower alkoxy group or the trifluoromethyl group; n is an integer between 1 and 3; m is an integer from 0 to 3; Z represents a hydrogen atom, a lower alkyl group or an aryl group of the formula: ##STR2## in which R.sub.6 has the same meaning as R.sub.1, R.sub.2, R.sub.3 or R.sub.4 ; and A is an oxygen atom or a group ##STR3## and to their pharmaceutically acceptable salts. Application: pharmeutical compositions with antidepressant properties.
    Type: Grant
    Filed: April 11, 1988
    Date of Patent: November 21, 1989
    Assignee: Les Laboratoires Meram
    Inventors: Andre Buzas, Roland Ollivier
  • Patent number: 4501891
    Abstract: This invention relates to the new papaverine carbanion of the formula: ##STR1## and to a preparation process of the same comprising reacting on papaverine, in a solvent, a slight excess of a highly basic agent.
    Type: Grant
    Filed: February 11, 1982
    Date of Patent: February 26, 1985
    Assignee: Andre Buzas
    Inventors: Andre Buzas, Gilbert Lavielle
  • Patent number: 4382935
    Abstract: The drug contains an active substance consisting of 1-(3'-benzofuryl)-4-benzylpiperazine. In order to prepare the compound, a reaction is carried out with reflux between 3-coumaranone and N-benzylpiperazine in the presence of acetic acid and in an aromatic solvent.
    Type: Grant
    Filed: January 29, 1981
    Date of Patent: May 10, 1983
    Assignees: Andre Buzas, Jean-Marie Melon, Laboratoires Sauba S.A., Universite d'Orleans
    Inventors: Andre Buzas, Jean-Marie Melon, Gilbert Lavielle, Andre Champagnac
  • Patent number: 4353911
    Abstract: The invention is a method of increasing femoral blood flow and vertebral blood flow a compound of the formula: ##STR1## wherein R is alkoxy carbonyl the alkoxy having up to 5 carbon atoms, trimethoxy substituted phenyl carbonyl or a therapeutically acceptable acid addition salt of one of the foregoing.
    Type: Grant
    Filed: July 20, 1979
    Date of Patent: October 12, 1982
    Inventor: Andre Buzas
  • Patent number: 4127666
    Abstract: The disubstituted 2,5-benzamides correspond to the following general formula: ##STR1## where R is an alkyl group (possessing 1 to 5 carbon atom) or an allyl group, ##STR2## represents one of the following groups: phenylpiperazine, benzylpiperazine, piperonylpiperazine, dimethylaminoethylamino, diethylaminoethylamino, pyrrolidinyl-1 substituted methylamino, morpholine or piperidine, R' is an alkyl possessing 1 to 8 carbon atoms, a phenyl, or substituted phenyl, an alpha-aminomethyl or acrylic group, Y is an oxygen atom, an oxime, oxime ether, oxime ester or imine group.
    Type: Grant
    Filed: February 15, 1977
    Date of Patent: November 28, 1978
    Assignee: Universite d'Orleans
    Inventors: Andre Buzas, Gilbert Lavielle
  • Patent number: 4096259
    Abstract: 1,4-DISUBSTITUTED PIPERAZINE DERIVATIVES HAVING THE FORMULA ##STR1## wherein R is C.sub.1-3 alkyl, halogen or hydrogen; R.sub.1 is phenyl or C.sub.1-3 alkyl; R' is hydrogen when R.sub.1 is alkyl and is the same as R when R.sub.1 is phenyl; R.sub.2 is hydrogen or C.sub.1-3 alkyl; n is 2-4; n' is 1-4; and A is a group comprising a trivalent organic function which may be acid, ester, nitrile or amide, in which latter case the nitrogen of the amide is part of the ring, and more particularly COOH, COONa, COOCH.sub.3 or COOC.sub.2 H.sub.5. These derivatives or their addition salts with pharmaceutically acceptable acids, have high psychostimulating activity.
    Type: Grant
    Filed: May 10, 1976
    Date of Patent: June 20, 1978
    Inventors: Andre Buzas, Jean-Marie Melon
  • Patent number: 4051259
    Abstract: The invention relates to 1-methyl-2-(m-trifluoromethylphenyl)-ethylamide of p-pentylaminophenoxyacetic acid and its pharmaceutically acceptable acid addition salts which have outstanding anorexigenic properties.
    Type: Grant
    Filed: April 2, 1976
    Date of Patent: September 27, 1977
    Assignee: Les Laboratoires Bruneau & Cie
    Inventors: Andre Buzas, Jacques Bruneau