Abstract: A hand-held surface cleaning device includes circuitry to communicate with a robotic surface cleaning device to cause the same to target an area/region of interest for cleaning. Thus, a user may utilize the hand-held surface cleaning device to perform targeted cleaning and conveniently direct a robotic surface cleaning device to focus on a region of interest. Moreover, the hand-held surface cleaning device may include sensory such as a camera device for extracting three-dimensional information from a field of view. This information may be utilized to map locations of walls, stairs, obstacles, changes in surface types, and other features in a given location. Thus, a robotic surface cleaning device may utilize the mapping information from the hand-held surface cleaning device as an input in a real-time control loop, e.g., as an input to a Simultaneous Localization and Mapping (SLAM) routine.

Abstract: In general, the present disclosure is directed to a hand-held surface cleaning device that includes a relatively compact form-factor to allow users to store the same in a nearby location (e.g., in a drawer, in an associated charging dock, on a table top) for easy access to perform relatively small cleaning tasks that would otherwise require retrieving a full-size vacuum from storage. A hand-held surface cleaning device consistent with aspects of the present disclosure includes a body (or body portion) with a motor, power source and dust cup disposed therein. The body portion also functions as a handgrip to allow the hand-held surface cleaning device to be operated by one hand, for example.

Abstract: A suprastructure comprising a modified influenza hemagglutinin (HA) is provided. The modified HA may comprise one or more than one alteration that reduces non-cognate binding of the modified HA to sialic acid (SA) on the surface of a cell, while maintaining cognate interaction with the cell, such as a B cell. A composition comprising the suprastructure and modified HA and a pharmaceutically acceptable carrier is also described. A method of increasing an immunological response or inducing immunity in response to a vaccine comprising the suprastructure and modified HA is also provided.

Abstract: A filter assembly is disclosed that has a body defining a cavity and having a first side edge surface, a second side edge surface, a top edge surface, and a bottom edge surface forming a perimeter surface around the cavity. A porous flow face extends across the cavity and is coupled to the perimeter surface. The porous flow face arcs between the first side edge surface and the second side edge surface. An adsorbent is disposed in the cavity.

Abstract: A cleaning apparatus includes an end cap assembly for use with an agitator. The end cap assembly includes a stationary end cap, a rotating end cap, and a fragmentor. The stationary end cap is secured to and stationary with respect to a housing of the cleaning apparatus. The rotating end cap is coupled to the agitator and rotates with the agitator relative to the housing. The stationary and rotating end caps define a gap extending radially inward therebetween. The fragmentor is disposed within the gap and is configured to break debris which enters the gap into smaller pieces. The fragmentor may be disposed on a surface of the stationary end cap facing towards the rotating end cap and/or on a surface of the rotating end cap facing towards the stationary end cap. The fragmentor may include a cutting blade and/or an abrasive surface.

Abstract: A docking station for a robotic cleaner may include a housing, at least one charging contact coupled to the housing, and at least three optical emitters disposed within the housing. The at least three optical emitters may include a first optical emitter configured to generate a first optical signal within a first field of emission, a second optical emitter configured to generate a second optical signal within a second field of emission, and a third optical emitter configured to generate a third optical signal within a third field of emission. The third optical emitter may be disposed between the first and second optical emitters. The first, second, and third optical signals may be different from each other. The third optical signal may be configured to guide a robotic cleaner in a direction of the housing.

Abstract: An example method includes obtaining an image of a lead implanted in a patient, the lead including one or more electrodes positioned along a longitudinal axis of the lead and a plurality of orientation markers; determining, in the image, respective locations of the electrodes and respective locations of the orientation markers; obtaining a template model corresponding to the lead; determining a transform between the determined locations of the one or more electrodes and the plurality of orientation markers and locations of corresponding electrodes and orientation markers in the template model; and determining the rotational orientation of the lead based on the transform.

Abstract: A reconfigurable surface treatment apparatus may include a wand and a pod removably coupled to the wand. The wand may have a first distal end that is configured to couple to a surface cleaning head and a second distal end that is configured to couple to a handle. The pod may include a suction motor assembly cavity, a battery cavity, and a dust cup cavity. The suction motor assembly cavity and the battery cavity may be disposed on opposing sides of a vertical plane, wherein the vertical plane extends along a central longitudinal axis of the pod. The dust cup cavity may be disposed between the suction motor assembly cavity and the battery cavity such that at least a portion of the dust cup cavity is disposed on each side of the vertical plane.

Abstract: Nucleic acids encoding norovirus VP1 fusion proteins and VLPs comprising the norovirus VP1 fusion proteins are provided. Methods for norovirus VP1 fusion protein and norovirus VLP production in plants are also described. The VP1 fusion protein comprises, a first sequence encoding an S domain derived from a first norovirus strain, and a second sequence encoding a P domain derived from a second norovirus strain.

Abstract: A vacuum cleaner attachment generally includes a cleaning element that floats relative to a suction conduit of the vacuum cleaner attachment. The cleaning element is supported on a support structure that is movably coupled to a housing and is biased towards a floor, for example, as a result of the weight of the cleaning element support structure. The cleaning element may be permanently attached to the support structure or may be a removable or disposable pad or sheet attached to the support structure. The floating cleaning element may be supported between the suction conduit and one or more wheels of the vacuum cleaner attachment. The vacuum cleaner attachment may be removably attached to a vacuum cleaner, for example, to be used interchangeably with other surface cleaning heads.

Abstract: Nucleic acids encoding modified norovirus VP1 proteins, and VLPs comprising one or more of the modified norovirus VP1 proteins are provided. Methods for modified norovirus VP1 protein, and norovirus VLP, production in plants, portions of the plant or a plant cell, are also described.

Abstract: A wheel assembly for a robotic cleaner may include a frame, a moveable arm pivotally coupled to the frame, a driven wheel rotatably coupled to the moveable arm such that the driven wheel pivots with the moveable arm, and a biasing mechanism configured to urge the driven wheel towards an extended position, the biasing mechanism being coupled to the frame and spaced apart from the moveable arm.

Abstract: Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.

Abstract: A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein and plant lipids. The invention is also directed to a nucleic acid encoding influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.

Abstract: Nucleic acids encoding norovirus VP1 fusion proteins and VLPs comprising the norovirus VP1 fusion proteins are provided. Methods for norovirus VP1 fusion protein and norovirus VLP production in plants are also described. The VP1 fusion protein comprises, a first sequence encoding an S domain derived from a first norovirus strain, and a second sequence encoding a P domain derived from a second norovirus strain.

Abstract: Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.

Abstract: A vacuum cleaner may include a suction motor and a cyclonic separator fluidly coupled to the suction motor. The cyclonic separator may include a chamber and a first and a second vortex finder extending within the chamber. The first and second vortex finders may extend from opposing sides of the chamber.

Abstract: A photovoltaic device is described, the device comprising a transparent conducting electrode layer; a back contact layer comprising at least one MXene material; and an active layer, comprising a photovoltaic active material, disposed between the transparent conducting electrode layer and the back contact layer. Also described is a method of producing a photovoltaic device, the method comprising the steps of providing substrate, depositing a transparent conducting electrode over the substrate; depositing an active layer comprising a photovoltaic material over the transparent conducting electrode; and depositing an MXene layer material over the active layer. A method of generating electricity using the disclosed device is also described.

Abstract: A doped organic semiconductor is produced using the method of providing an organic semiconductor solution, contacting the organic semiconductor solution with CO2; and irradiating the organic semiconductor solution with ultraviolet light. A composition is described, the composition comprising an organic semiconductor; and a metal salt having the formula M+X? wherein X? is a monoanionic species; and wherein the ratio of M+ to X? in the hole transport material is less than about 1.00. An additional composition is described, the composition comprising an organic semiconductor; a metal salt having the formula M+X? wherein X? is a monoanionic species; and a metal carbonate; wherein the total metal content of the composition is approximately equal to the X? content of the composition.