Patents by Inventor Andre Delacourte

Andre Delacourte has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of 1,4-bis (3-aminoalkyl) piperazine derivatives in the treatment of neurodegenerative diseases
    Patent number: 9044478
    Abstract: Use of 1,4-bis(3-aminoalkyl)piperazine derivatives as defined in formula I or II for the manufacture of a pharmaceutical composition intended for the treatment of neurodegenerative diseases, related neurodegenerative diseases, developmental diseases or cancer. The instant invention is also directed to some specific 1,4-bis(3-aminoalkyl)piperazine derivatives and pharmaceutical composition including them.
    Type: Grant
    Filed: November 8, 2005
    Date of Patent: June 2, 2015
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE DU DROIT ET DE LA SANTA-LILLE II
    Inventors: Nicolas Sergeant, Andre Delacourte, Patricia Melnyk, Luc Buee
  • Heterocycle compounds and uses thereof for the prevention or treatment of diseases involving formation of amyloid plaques and/or where a dysfunction of the APP metabolism occurs
    Patent number: 8680095
    Abstract: The present invention relates to compounds having the following Formula (I) for use in the prevention and/or the treatment of diseases involving formation of amyloid plaques and/or where a dysfunction of the APP metabolism occurs.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: March 25, 2014
    Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Universite Lille 2 Droit et Sante, Centre National de la Recherche Scientifique (C.N.R.S.), Universite Lille 1—Sciences et Technologies
    Inventors: Andre Delacourte, Patricia Melnyk, Stephane Burlet, Nicolas Lefur
  • Antibodies specific of the ?-amyloid peptides and their uses as diagnostic agents or drugs
    Patent number: 8343493
    Abstract: A monoclonal antibody which specifically binds to the N-terminal region of A?8-x peptide, x being included from 11 to 42, and recognizes neither A?1-40 nor A?1-42 and which presents a high affinity with respect to A?8-x peptide, such as determined by an immunological complex formation between the monoclonal antibody and the peptide A?8-x.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: January 1, 2013
    Assignees: Innogenetics N.V., INSERM (Institut National de la Sante et de la Recherche Medicale), Sanofi
    Inventors: Eugeen VanMechelen, Pierre Grognet, Nicolas Sergeant, Marie Gompel, Andre Delacourte, Luc Buee, Laurent Pradier, Veronique Blanchard-Bregeon
  • NEW HETEROCYCLE COMPOUNDS AND USES THEREOF FOR THE PREVENTION OR TREATMENT OF DISEASES INVOLVING FORMATION OF AMYLOID PLAQUES AND/OR WHERE A DYSFUNCTION OF THE APP METABOLISM OCCURS
    Publication number: 20120283256
    Abstract: The present invention relates to compounds having the following Formula (I) for use in the prevention and/or the treatment of diseases involving formation of amyloid plaques and/or where a dysfunction of the APP metabolism occurs.
    Type: Application
    Filed: December 16, 2010
    Publication date: November 8, 2012
    Inventors: Andre Delacourte, Patricia Melnyk, Stephane Burlet, Nicolas Lefur
  • PREVENTION, TREATMENT AND DIAGNOSIS OF DISEASES ASSOCIATED WITH BETA-AMYLOID FORMATION AND/OR AGGREGATION
    Publication number: 20120258872
    Abstract: The invention provides compositions and methods for prevention and treatment of diseases associated with ?-amyloid formation and/or aggregation. Such methods encompass the induction of an immune response against N-terminal truncated and/or post-translationally modified A? peptides. These peptides are further used in compositions and methods for the diagnosis of diseases associated with ?-amyloid formation and/or aggregation.
    Type: Application
    Filed: June 20, 2011
    Publication date: October 11, 2012
    Inventors: André Delacourte, Nicolas Sergeant
  • ANTIBODIES SPECIFIC OF THE BETA-AMYLOID PEPTIDES AND THEIR USES AS DIAGNOSTIC AGENTS OR DRUGS
    Publication number: 20110059092
    Abstract: The present invention relates to a monoclonal antibody which specifically binds to the N-terminal region of A?8-x peptide, x being comprised from 11 to 42, and recognises neither A?1-40 nor A?1-42 and which presents a high affinity with respect to A?8-x peptide, such as determined by an immunological complex formation between the monoclonal antibody and the peptide A?8-x.
    Type: Application
    Filed: October 24, 2008
    Publication date: March 10, 2011
    Applicants: INNOGENETICS NV, SANOFI-AVENTIS
    Inventors: Eugeen Vanmechelen, Pierre Grognet, Nicolas Sergeant, Marie Gompel, Andre Delacourte, Luc Buee, Laurent Pradier, Veronique Blanchard-bregeon
  • Means for detecting pathological transformation of the APP protein and their uses
    Patent number: 7723117
    Abstract: Pathological modifications of the APP protein can be detected in a sample by use of markers consisting of catabolic and/or metabolic fragments of the carboxyl-terminal part of the APP (APP-Cter fragments) resulting from a neurodegenerative condition wherein the APP participates in the etiology. Methods for detecting such markers provide diagnostic and therapeutic applications in degenerative pathologies such as Alzheimer's Disease.
    Type: Grant
    Filed: November 5, 2001
    Date of Patent: May 25, 2010
    Assignee: Institut National de la Sante et de la Recherche Medicale (INSERM)
    Inventors: André Delacourte, Nicolas Sergeant, Dorothée Vanuxeem
  • Use of 1,4-bis (3-aminoalkyl) piperazine derivatives in the treatment of neurodegenerative diseases
    Publication number: 20090149464
    Abstract: Use of 1,4-bis(3-aminoalkyl)piperazine derivatives as defined in formula I or II for the manufacture of a pharmaceutical composition intended for the treatment of neurodegenerative diseases, related neurodegenerative diseases, developmental diseases or cancer. The instant invention is also directed to some specific 1,4-bis(3-aminoalkyl)piperazine derivatives and pharmaceutical composition including them.
    Type: Application
    Filed: November 8, 2005
    Publication date: June 11, 2009
    Applicants: UNIVERSITE DU DROIT ET DE LA SANTE- LILLE II, Institut National De La Sante Et De La Recherche Medicale (Inserm)
    Inventors: Nicolas Sergeant, Andre Delacourte, Patricia Melnyk, Luc Buee
  • Prevention, treatment and diagnosis of diseases associated with beta-amyloid formation and/or aggregation
    Publication number: 20080299111
    Abstract: The invention provides compositions and methods for prevention and treatment of diseases associated with ?-amyloid formation and/or aggregation. Such methods encompass the induction of an immune response against N-terminal truncated and/or post-translationally modified A? peptides. These peptides are further used in compositions and methods for the diagnosis of diseases associated with ?-amyloid formation and/or aggregation.
    Type: Application
    Filed: May 6, 2008
    Publication date: December 4, 2008
    Inventors: Andre Delacourte, Nicolas Sergeant
  • Means for detecting pathological transformation of the app protein and their uses
    Publication number: 20070026527
    Abstract: A method of intra-articular drug delivery may include selecting an attachment zone in a synovial joint; affixing a drug release device in the attachment zone, the drug release device comprising a base affixable in the attachment zone, a sustained-release drug carrier, and a drug, the device positioned so that the device releases the drug into the synovial fluid of the synovial joint, and so that agitation of the synovial fluid facilitates elution of the drug from the drug release device.
    Type: Application
    Filed: November 5, 2001
    Publication date: February 1, 2007
    Inventors: Andre Delacourte, Nicolas Sergeant, Dorothee Vanuxeem
  • Means for detecting neurodegenerative processes and applications of same
    Publication number: 20060166283
    Abstract: The invention relates to novel markers of the neurodegenerative process, comprising the ? chain of the modified ATP synthase. The invention also relates to methods of detection, diagnosis, antibodies, kits and applications of same.
    Type: Application
    Filed: September 8, 2003
    Publication date: July 27, 2006
    Inventors: Andre Delacourte, Nicolas Sergeant, Annick Wattez
  • Prevention, treatment and diagnosis of diseases associated with beta-amyloid formation and/or aggregation
    Publication number: 20050175626
    Abstract: The invention provides compositions and methods for prevention and treatment of diseases associated with ?-amyloid formation and/or aggregation. Such methods encompass the induction of an immune response against N-terminal truncated and/or post-translationally modified A? peptides. These peptides are further used in compositions and methods for the diagnosis of diseases associated with ?-amyloid formation and/or aggregation.
    Type: Application
    Filed: July 23, 2003
    Publication date: August 11, 2005
    Inventors: Andre Delacourte, Nicolas Sergeant