Abstract: A method of detecting a level of gas in a closed coolant system by a gas level monitoring system includes detecting a level of gas pressure applied to the closed coolant system, detecting a change of fluid pressure in the closed coolant system in response to the applied gas pressure, and determining the level of gas in the closed coolant system based on the change of fluid pressure in the closed coolant system in response to the applied gas pressure. Related coolant systems and gas level monitoring systems are disclosed.

Abstract: A medical instrument includes an elongate shaft, a handle coupled to a proximal portion of the elongate shaft, an axle rotatably mounted to the handle and configured so that rotation of the axle causes the elongate shaft to rotate about an axis of the elongate shaft, and an axle catch disposed at least partially within the handle, the axle catch being actuatable between a locked position, in which the axle catch impedes rotation of the axle, and an unlocked position, in which the axle catch permits rotation of the axle. Mounting the handle on a robotic manipulator causes the axle catch to automatically transition from the locked position to the unlocked position.

Abstract: The present disclosure provides adeno-associated vector (AAV)-based methods of increasing gene expression of a GBA1 in floor plate midbrain progenitor cells, determined dopamine (DA) neuron progenitor cells, and/or DA neurons, or glial cells, including those differentiated from pluripotent stem cells, and methods of lineage specific differentiation of the same. Also provided are compositions and uses thereof, such as for treating neurodegenerative diseases and conditions, including Parkinson's disease.

Abstract: The present invention provides dihydroquinolinone compounds which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and alter the substrate specificity of the CRBN E3 ubiquitin ligase complex, resulting in breakdown of intrinsic downstream proteins. The disclosed compounds are useful for the treatment of cancer.

Abstract: The invention provides an aquaculture system (2000) for hosting an aquatic animal. the aquaculture system (2000) comprising (i) a basin (50) configured to host water (51) and the aquatic animal. and (ii) a light generating system (1000) configured to provide system light (1001) to the basin (50), wherein the system light (1001) has controllable polarization. and wherein in an operational mode of the light generating system (1000) the light generating system (1000) is configured to provide system light (1001) sequentially having M different polarization states, wherein M?2. and wherein at least part of the M different polarization states are provided consecutively for time periods selected from the range of 0.005-10 seconds.

Abstract: Methods for determining formation density of downhole formations include obtaining first density data (?SS) using a short-spaced detector configured to detect reflections of a signal transmitted into the downhole formation, obtaining second density data (?LS) using a long-spaced detector configured to detect reflections of the transmitted signal from the downhole formation, wherein the long-spaced detector is located a greater distance from a source than the short-spaced detector, and determining if a measured data point based on ?SS and ?LS falls within a unity area of a spine-and-rib plot. When the measured data point falls within the unity area, the formation density using a first mathematical relationship is determined and when the measured data point falls outside the unity area, the formation density using a second mathematical relationship different from the first mathematical relationship is determined.

Abstract: A propane tank with a valve passage containing a valve has a protection cap with a projecting pin which extends into the passage adjacent the valve to provide a secondary seal. The projecting pin is defined by an annular sleeve surrounding a hollow interior extending up to the upper wall where the sleeve has an outside surface tapered from the upper wall to the remote end and an inside surface tapered from the remote end to the upper wall and the passage carries an O-ring seal arranged so that movement of the upper wall in a direction away from the passage caused by pressure release is insufficient to cause release of the secondary seal between the projecting pin member from the O-ring seal. The projecting element extends into the hollow interior to a position beyond the remote end of an actuating pin of the valve.

Abstract: Compounds of the formula (I), are disclosed wherein the substituents are as defined in claim 1. Furthermore, the present invention relates to agrochemical compositions which comprise compounds of formula (I), to preparation of these compositions, and to the use of the compounds or compositions in agriculture or horticulture for combating, preventing or controlling animal pests, including arthropods and in particular insects or representatives of the order Acarina.

Abstract: It was previously demonstrated that the RAC2 G12R mutation rapidly induced HSPCs cell death and hematopoiesis regulation. Now, the invention evaluated the impact of said mutation on three tumor cell lines: MDA-MB-231 (mammary gland adeno-carcinoma), HT29 (colorectal adenocarcinoma) and HepG2 (hepatocellular carcinoma). Briefly, cells were transduced with a lentiviral vector containing the green fluorescent protein (GFP) reporter cDNA (WPI) or a wild type form of RAC2 cDNA (WT) or a RAC2 mutated cDNA form (G12R). The inventors showed that the number of GFP+ cells is drastically lower in the G12R condition as compared to the WT and WPI conditions. The cell morphology and content are particularly disrupted. These observations were confirmed in a time-course proliferation assay performed on MDA-MB-231 and HT29 cell lines. Altogether, these data underlie the deleterious impact of the RAC2 G12R mutation on tumor cell lines proliferation.

Abstract: The present disclosure relates to a method for controlling an electrical generator of a wind turbine, the generator having a rotor and a stator, and the stator being controlled by a stator current. The stator current has a main component being characterized by a fundamental signal with a fundamental frequency and a fundamental phase angle, and a fractional harmonic current component being characterized by a fractional harmonic signal having a fractional harmonic frequency and a fractional harmonic phase angle. The method includes providing a compensation current having a compensation amplitude and a compensation phase angle, and determining the compensation phase angle depending on an absolute rotational position of the rotor.

Abstract: The present invention relates to an electric power and hydrogen generation system comprising a tower having an internal structure and an external structure, said internal and external structures being interconnected; a plurality of helical turbines each coupled to an electric generator, said turbines being arranged vertically one above the other inside the internal structure; a plurality of humidity and water collectors arranged in the interconnection spaces of said internal and external structures; the external structure presents outer surfaces, which are covered using solar cells; a tower base holds within it a system for the production, storage and supply of hydrogen and electricity.

Abstract: An optical apparatus is disclosed, the apparatus comprising an optical element having a reflective surface for reflecting incident radiation in a beam path, and at least one sensor configured to sense radiation corresponding to a temperature of a respective portion of a backside surface of the optical element. Also disclosed is a method of controlling a temperature of a reflective surface of an optical element in a lithographic apparatus.

Abstract: A method of coordinating allocation of radio processing operations associated with multiple vRAN nodes to shared computing resources is provided. The method includes receiving, by a centralized Acceleration Abstraction Layer (AAL) broker implemented on top of a shared accelerating computing infrastructure, an operation request from a virtual operation associated with a vRAN node, the operation request specifying an operation to be accelerated. The AAL broker selects, using a predefined or configurable scheduling policy, a physical hardware accelerator for accelerated execution of the operation. The AAL broker forwards the operation request to a processing queue of the selected hardware accelerator.

Abstract: A radar system comprises a transmit antenna that transmits a radar signal and a receive antenna that receives a radar return. The system further comprises one or more processors configured to perform acts comprising: detecting object based on information in the radar return. The acts further comprise generating and providing to a tracking system a point cloud comprising information related to the detected object. Additionally, the acts comprise receiving from the tracking system an indication of a predicted cell in which the detected object is predicted to be located in a subsequent radar frame, wherein the predicted cell is associated with a confidence value. The acts further comprise reducing, for the subsequent radar frame, a detection threshold value for the predicted cell.

Abstract: A method, computer system, and a computer program product are provided for providing a multi-perspective multimedia output. In one embodiment, this comprises a first captured version of an event from a first capturing device and a second captured version of the event from a second capturing device. A geolocation polygon is then calculated based on a geolocation of the first capturing device used as a first point of reference, and a geolocation of the second capturing device used as a second point of reference. An ephemeral cloud is then established by determining any digital resources available within the geolocation polygon. The first and second captured versions are then processed by using the resources available within said ephemeral cloud. A single output is then generated using the processed first and second captured versions. The single output is a combination of the first and second captured versions.

Abstract: Medical apparatus includes one or more magnetic field generators, which are configured to generate magnetic fields within a body of a patient. An invasive probe includes an insertion tube having a distal end, which is configured for insertion into the body, and a plurality of flexible splines configured to be deployed from the distal end of the insertion tube. Each spline includes a flexible, multilayer circuit board and a conductive trace that is formed in at least one layer of the circuit board and is configured to define one or more coils, which are disposed along a length of the spline and output electrical signals in response to the magnetic fields. A processor is coupled to receive and process the electrical signals output by the coils in order to derive respective positions of the flexible splines in the body.

Abstract: In one implementation, a device generates a response to user input using a first language model. The device determines that the response is an erroneous response. The device generates a resolution to the erroneous response using a teacher language model. The device updates the first language model using the resolution from the teacher language model.

Abstract: The invention relates to the field of antibodies. In particular it relates to the field of therapeutic (human) antibodies for the treatment of ErbB-2/ErbB-3 positive cells. More in particular it relates to treating of cells comprising an NRG1 fusion gene comprising at least a portion of the NRG1-gene fused to a sequence from a different chromosomal location.