Abstract: A system for precision psychiatry includes a wearable device including a cap and EEG electrodes attached thereto, the cap configured to be placed over a head of a user and including a plurality of first linear actuators configured to expand and contract to increase and decrease a size of the cap, respectively, the EEG electrodes connected to the cap via a plurality of second linear actuators configured to expand and contract to move the EEG electrode toward and away from, respectively, a scalp of the user, a processing device configured to be connected to the EEG electrodes of the wearable device to know the 3-D location of the EEG electrodes and to receive brain activity signals therefrom, the processing device generating a neurofeedback signal based on a detected aberrant brain activity, and a feedback device providing the neurofeedback signal to the user.

Abstract: An apparatus for producing a clean air curtain to protect a first individual and a second individual from germ transfer between themselves has a housing having an input port and an output port. The apparatus comprises a fan disposed in the housing in communication with the input port to draw air into an input channel through the input port, and in communication with the output port through an output channel to force air from the input channel through the output channel and out the output port. The output channel configured to cause the air forced out the output port to create a laminar flow air curtain. The apparatus has an air filter positioned across the input channel to clean the air drawn through the input port. A method for protecting a first individual and a second individual from germ transfer between themselves with an air curtain.

Abstract: A system and a method for detecting mild traumatic brain injury (mTBI) includes a memory arrangement including stored brain data corresponding to electrical activity of a brain of a subject at locations in the brain during a first time period. In addition, the system includes a processor receiving the stored brain data and current brain data corresponding to electrical activity of the brain of the subject at the plurality of locations during a second time period, wherein the second time period is after the first time period. The processor generates a first set of phase synchrony measures (PSM) corresponding to frequency band-specific oscillatory phase synchrony of the stored brain data, and a second set of PSM corresponding to frequency band-specific oscillatory phase synchrony of the current brain data. The processor determines a likelihood of mTBI based on the first and second sets of PSM.

Abstract: A system and method for the acquisition and analysis of physiological data, such as for example, electrophysiological data including but not limited to EEG, EKG, EMG EOG, and biomechanical data relating to breathing and/or respiration to provide further insight to the person's health and/or behavior. A plurality of self-contained sensors having an electrically-conducting interface, an amplifier, an analog to digital converter, and a wireless transceiver may be used. Each of the self-contained sensors may be about the size of a watch battery. A sensor array embedded within a conductive fabric may also be used to detect physiological data. The conductive fabric may be included a plurality of conduct nodes rising out of a surface of the conductive fabric or may be a quilted meshwork having a plurality of sections, each section forming a conductive surface for detecting physiological data.

Abstract: An ambulatory intrinsic brain signal processor circuit is coupled to a plurality of electrodes. The signal processor circuit can include a digital multiplexer circuit coupled to the electrodes to multiplex brain signal data from different electrodes together into a multiplexed data stream. An ambulatory transceiver circuit wirelessly communicates information to and from a remote transceiver. A controller circuit permits a user to control which of the electrodes contribute data, a data resolution, and whether the data includes one or both of neural action or local field potential data. Seizure prediction components and methods are also described.

Abstract: An EEG kit can be thought of as “EEG In a Bag” (“EEG-IAB”). The EEG kit can provide a complete, disposable, fast, and easily-used platform to record EEG to measure brain activity. Other physiological information (e.g., oxygen saturation, ECG or EKG, etc.) or other information (e.g., local electrode motion) can also be recorded, such as in time-concordance with the recorded EEG signals. The recorded EEG and other information can be uplinked to a local or remote user interface. A local or remote neurologist can use the EEG information to render a diagnosis in tens of minutes, wherein such information can currently be unavailable, or can require a number of hours to obtain and diagnose. The EEG kit can be very convenient, and can be used in a hospital emergency department (ED), an intensive care unit (ICU), by a first responder, or can be deployed for emergency or disaster preparedness.

Abstract: Inter-rater and intra-rater reliability of physiological scan interpretation is herein described. A plurality of physiological scan interpretations may be collected for a physiological scan. A physiological scan interpretation reliability score may be calculated for the physiological scan based on the plurality of physiological scan interpretations. When the reliability score falls below a predetermined threshold, an additional physiological scan interpretation may be collected for the physiological scan. The reliability score may be recalculated using the additional physiological scan interpretation.

Abstract: An EEG kit can be thought of as “EEG In a Bag” (“EEG-IAB”). The EEG kit can provide a complete, disposable, fast, and easily-used platform to record EEG to measure brain activity. Other physiological information (e.g., oxygen saturation, ECG or EKG, etc.) or other information (e.g., local electrode motion) can also be recorded, such as in time-concordance with the recorded EEG signals. The recorded EEG and other information can be uplinked to a local or remote user interface. A local or remote neurologist can use the EEG information to render a diagnosis in tens of minutes, wherein such information can currently be unavailable, or can require a number of hours to obtain and diagnose. The EEG kit can be very convenient, and can be used in a hospital emergency department (ED), an intensive care unit (ICU), by a first responder, or can be deployed for emergency or disaster preparedness.

Abstract: A high throughput neurophysiological assay for identifying anti-psychotic compounds is disclosed. In particular, a high throughput neurophysiological assay using information obtained from injecting a neural activity blocker, such as tetrodotoxin (TTX), into one hippocampus persistently coactivated pyramidal cells in the uninjected hippocampus that initially discharged independently. In accord with the definition of cognitive disorganization, pyramidal cell firing rates only changed for 15 min and did not accompany the coactivation. The disclosed assay uses the TTX-induced coactivity of hippocampal pyramidal cell discharge to identify compounds that may prevent or attenuate the changes in the hippocampal pyramidal cell discharge observed when a neural activity blocker is administered. The assays of the invention are useful for high throughput screening of targets in the discovery of drugs that have anti-psychotic properties.

Abstract: An ambulatory intrinsic brain signal processor circuit is coupled to a plurality of electrodes. The signal processor circuit can include a digital multiplexer circuit coupled to the electrodes to multiplex brain signal data from different electrodes together into a multiplexed data stream. An ambulatory transceiver circuit wirelessly communicates information to and from a remote transceiver. A controller circuit permits a user to control which of the electrodes contribute data, a data resolution, and whether the data includes one or both of neural action or local field potential data. Seizure prediction components and methods are also described.

Abstract: An ambulatory intrinsic brain signal processor circuit is coupled to a plurality of electrodes. The signal processor circuit can include a digital multiplexer circuit coupled to the electrodes to multiplex brain signal data from different electrodes together into a multiplexed data stream. An ambulatory transceiver circuit wirelessly communicates information to and from a remote transceiver. A controller circuit permits a user to control which of the electrodes contribute data, a data resolution, and whether the data includes one or both of neural action or local field potential data. Seizure prediction components and methods are also described.

Abstract: A high throughput neurophysiological assay for identifying anti-psychotic compounds is disclosed. In particular, a high throughput neurophysiological assay using information obtained from injecting a neural activity blocker, such as tetrodotoxin (TTX), into one hippocampus persistently coactivated pyramidal cells in the uninjected hippocampus that initially discharged independently. In accord with the definition of cognitive disorganization, pyramidal cell firing rates only changed for 15 min and did not accompany the coactivation. The disclosed assay uses the TTX-induced coactivity of hippocampal pyramidal cell discharge to identify compounds that may prevent or attenuate the changes in the hippocampal pyramidal cell discharge observed when a neural activity blocker is administered. The assays of the invention are useful for high throughput screening of targets in the discovery of drugs that have anti-psychotic properties.

Abstract: Bioelectrical activity in a living animal or human subject is monitored by detecting the bioelectrical signals at a number of points digitizing and multiplexing the electrical signals and transmitting the multiplexed stream by digital radio transmission circuitry. The received data stream is then demultiplexed and monitored to allow the activity at the points on the animal subject to be monitored.

Abstract: Bioelectrical activity in a living animal subject is monitored by detecting the bioelectrical signals at a number of points multiplexing the electrical signals and transmitting a multiplexed stream by cellular telephone circuitry. The received data stream is then demultiplexed and monitored to allow the activity at the points on the animal subject to be monitored.