Abstract: The present disclosure, at least in part, relates to compositions (e.g., engineered nucleic acids and engineered proteins) and methods for increasing gene expression. The engineered proteins include RNA-binding proteins (e.g., RNA-binding proteins that comprise a Interleukin Enhancer Binding Factor 3 (ILF3) sequence, a Cas sequence, or a combination thereof). In some aspects, the disclosure provides methods of identifying engineered nucleic acids that are shorter in length than a gene of interest to induce expression of the gene of interest and also provides RNA-binding proteins for inducing gene expression.

Abstract: A method, system and computer program product relating to an application server operable to manage a microservice-based application, i.e. app, on behalf of clients, the clients being available for use by system actors who may be, for example, end users, bots, developers or other apps. A permissions validator is used to compute effective permissions in response to client requests. The requests are granted or denied conditional on the effective permissions being at least a subset of the permissions required to be given by any of the app's microservices that are needed for the resource being requested. The effective permissions are computed from an intersection of a set of actor permissions, a set of client permissions and a set of resource permissions.

Abstract: A method, system and computer program product relating to an application server operable to manage a microservice-based application, i.e. app, on behalf of clients, the clients being available for use by system actors who may be, for example, end users, bots, developers or other apps. A permissions validator is used to compute effective permissions in response to client requests. The requests are granted or denied conditional on the effective permissions being at least a subset of the permissions required to be given by any of the app's microservices that are needed for the resource being requested. The effective permissions are computed from an intersection of a set of actor permissions, a set of client permissions and a set of resource permissions.

Abstract: The invention is based on the detection of microRNA (miR) in biological samples derived from subjects for assessing a risk that the subject develops a neurological and/or neuropsychological condition. The invention in particular detects the presence or absence and the amount of microRNA-181a-5p, microRNA146a-5p and/or microRNA148a-3p in such samples, which are shown by the invention to be associated with the neurological and/or neuropsychological condition. In addition, the invention provides a therapeutic application for the treatment of the neurological and/or neuropsychological condition by modulating the expression/function of these miR. Furthermore, the invention provides a method for monitoring the treatment success of the neurological and/or neuropsychological condition.

Abstract: A method, system and computer program product relating to an application server operable to manage a microservice-based application, i.e. app, on behalf of clients, the clients being available for use by system actors who may be, for example, end users, bots, developers or other apps. A permissions validator is used to compute effective permissions in response to client requests. The requests are granted or denied conditional on the effective permissions being at least a subset of the permissions required to be given by any of the app's microservices that are needed for the resource being requested. The effective permissions are computed from an intersection of a set of actor permissions, a set of client permissions and a set of resource permissions.

Abstract: A method, system and computer program product relating to an application server operable to manage a microservice-based application, i.e. app, on behalf of clients, the clients being available for use by system actors who may be, for example, end users, bots, developers or other apps. A permissions validator is used to compute effective permissions in response to client requests. The requests are granted or denied conditional on the effective permissions being at least a subset of the permissions required to be given by any of the app's microservices that are needed for the resource being requested. The effective permissions are computed from an intersection of a set of actor permissions, a set of client permissions and a set of resource permissions.

Abstract: A method, system and computer program product relating to an application server operable to manage a microservice-based application, i.e. app, on behalf of clients, the clients being available for use by system actors who may be, for example, end users, bots, developers or other apps. A permissions validator is used to compute effective permissions in response to client requests. The requests are granted or denied conditional on the effective permissions being at least a subset of the permissions required to be given by any of the app's microservices that are needed for the resource being requested. The effective permissions are computed from an intersection of a set of actor permissions, a set of client permissions and a set of resource permissions.

Abstract: A method, system and computer program product relating to an application server operable to manage a microservice-based application, i.e. app, on behalf of clients, the clients being available for use by system actors who may be, for example, end users, bots, developers or other apps. A permissions validator is used to compute effective permissions in response to client requests. The requests are granted or denied conditional on the effective permissions being at least a subset of the permissions required to be given by any of the app's microservices that are needed for the resource being requested. The effective permissions are computed from an intersection of a set of actor permissions, a set of client permissions and a set of resource permissions.

Abstract: The present disclosure involves systems, software, and computer implemented methods for automatically providing delta query support for backend databases. One example method includes identifying annotations for a data set. The annotations indicate data fields of the data set to be used for a delta calculation. A request for a delta calculation is received for the data set. A set of delta calculation queries are automatically generated based on the annotations and a set of query templates in response to the request for the delta calculation. The set of delta calculation queries are executed to generate a delta calculation result. The automatically generated delta calculation result is provided in response to the request for the delta calculation.

Abstract: A method, system and computer program product relating to an application server operable to manage a microservice-based application, i.e. app, on behalf of clients, the clients being available for use by system actors who may be, for example, end users, bots, developers or other apps. A permissions validator is used to compute effective permissions in response to client requests. The requests are granted or denied conditional on the effective permissions being at least a subset of the permissions required to be given by any of the app's microservices that are needed for the resource being requested. The effective permissions are computed from an intersection of a set of actor permissions, a set of client permissions and a set of resource permissions.

Abstract: A method, system and computer program product relating to an application server operable to manage a microservice-based application, i.e. app, on behalf of clients, the clients being available for use by system actors who may be, for example, end users, bots, developers or other apps. A permissions validator is used to compute effective permissions in response to client requests. The requests are granted or denied conditional on the effective permissions being at least a subset of the permissions required to be given by any of the app's microservices that are needed for the resource being requested. The effective permissions are computed from an intersection of a set of actor permissions, a set of client permissions and a set of resource permissions.

Abstract: Prioritization criteria can be applied to assign a priority ranking to server processes executed by a backend server, and a utilization of the backend server by server demands can be quantified. Upon determining that the quantified utilization of the backend server has reached or exceeded one or more determined limits on backend utilization, at least a lowest priority server process can be throttled based on one or more throttling parameters.

Abstract: The present disclosure involves systems, software, and computer implemented methods for automatically providing delta query support for backend databases. One example method includes identifying annotations for a data set. The annotations indicate data fields of the data set to be used for a delta calculation. A request for a delta calculation is received for the data set. A set of delta calculation queries are automatically generated based on the annotations and a set of query templates in response to the request for the delta calculation. The set of delta calculation queries are executed to generate a delta calculation result. The automatically generated delta calculation result is provided in response to the request for the delta calculation.

Abstract: An arrangement and a method for controlling a plurality of light emitting diodes which are connected in series to attain uniform distribution of a total current to several series connections, LED chains, connected in parallel to each other wherein circuitry-related expenditure and power losses occurring during the control process are minimized, include a first reference voltage generating unit and a second reference voltage generating unit, wherein a outlet of the first reference voltage generating unit is connected to a first and a second control circuit, and an outlet of the second reference voltage generating unit is connected to the second and the first control circuit, and an outlet of the first control circuit is connected to a control inlet of the first controllable semiconductor switch, and an outlet of the second control circuit is connected to a control inlet of the second controllable semiconductor switch.

Abstract: An arrangement and a method for controlling a plurality of light emitting diodes which are connected in series to attain uniform distribution of a total current to several series connections, LED chains, connected in parallel to each other wherein circuitry-related expenditure and power losses occurring during the control process are minimized, include a first reference voltage generating unit and a second reference voltage generating unit, wherein a outlet of the first reference voltage generating unit is connected to a first and a second control circuit, and an outlet of the second reference voltage generating unit is connected to the second and the first control circuit, and an outlet of the first control circuit is connected to a control inlet of the first controllable semiconductor switch, and an outlet of the second control circuit is connected to a control inlet of the second controllable semiconductor switch.

Abstract: Provided herein are methods and compositions for enhancing the cognitive performance of a subject in need thereof. A method may include administering to a subject an agent that increases the level of protein or activity of a sirtuin, such as SIRT1.

Abstract: The present invention provides for a composition to be applied in the treatment of borreliosis and a kit. The composition includes four groups of components with which group A) the components 1000-5000 mgs Cat's Claw, 1000-3000 mgs Krill Oil or Kalamarine Oil or combinations of it, 200-600 mgs Magnesium Malate, 3000-5000 mgs ester C, 100-300 mgs Alpha-Lipoic Acid, 25-75 mgs Pyridoxyl-5-Phosphate (vitamin B6), 6000-14000 IU Cholecalciferol (vitamin D3), 2000-4000 mgs He Shou Wu, 1200-2500 mgs Purple Clovers Tea, 10-50 mls parsley juice, the group B) 2000-4000 mgs Monolaurine, 400-800 mgs N-Acetylcysteine, 100-300 mgs Hyaluronic acid with BioCell collagens II, 1-5 drops Teasel Root, the group C) 10-70 drops Spilanthes Acmella and the group D) 500-1500 ?g Cyancobalamin (vitamin B12).

Abstract: Prioritization criteria can be applied to assign a priority ranking to server processes executed by a backend server, and a utilization of the backend server by server demands can be quantified. Upon determining that the quantified utilization of the backend server has reached or exceeded one or more determined limits on backend utilization, at least a lowest priority server process can be throttled based on one or more throttling parameters.

Abstract: In a first aspect, the present invention relates to a method for prevention or treating memory impairment and/or a neurodegenerative condition, disorder or disease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound targeting a miRNA or any precursor, or targeting the activity of said miRNA or any precursor thereof. In particular, the present invention relates to a method wherein the targeted miRNA is miR-34. Moreover, the present invention relates to a method for improving memory functionality in a subject suffering from memory loss, said method comprises the reduction or reducing the level of miR-34 levels or precursor molecule levels in brain tissue of said subject administering to the subject a therapeutically effective amount of a compound targeting miR-34 or any precursor thereof.

Abstract: The invention relates to methods and products for enhancing and improving recovery of lost memories. In particular the methods are accomplished by inhibiting HDAC2 and or selectively inhibiting HDAC1/2 or HDAC1/2/3.