Patents by Inventor Andre G. Machado
Andre G. Machado has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11484711Abstract: This disclosure relates to using stereo-thermo-lesioning (STL) to create lesions at one or more locations in the patient's nervous system at the patient's bedside without general anesthesia. A method that uses STL to treat a patient's neurological condition includes: using a plurality of stereotactically-implanted thermo-coupled multi-contact electrodes to record conduction data within a predetermined theoretical zone of activity within the patient's neurological tissue; detecting abnormal neurological activity of a neurological condition within the conduction data and localize a portion of the predetermined theoretical zone of activity that is responsible for a primary organization of the abnormal neurological activity; creating a lesion at the portion of the predetermined theoretical zone of activity that is responsible for a primary organization of the abnormal neurological activity using at least one contact of the plurality of thermo-coupled multi-contact electrodes.Type: GrantFiled: July 26, 2017Date of Patent: November 1, 2022Assignee: THE CLEVELAND CLINIC FOUNDATIONInventors: Jorge A. Gonzalez-Martinez, John T. Gale, Andre G. Machado, Imad Najm
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Patent number: 10028695Abstract: This disclosure relates to a system and method to evaluate movement disorders. A movement data aggregator can combine data from a plurality of sensors into an aggregate movement data describing multi-dimensional movement of a handheld device. A calculator to compute an indication of a movement disorder based on the movement vector data and user input data, the user input data being generated in response to physical interaction between the handheld device and a human machine interface of a computing device/machine that is separate from the handheld device. In some examples, the handheld device can communicate with computing device via a wireless interface.Type: GrantFiled: November 12, 2015Date of Patent: July 24, 2018Assignee: The Cleveland Clinic FoundationInventors: Andre G. Machado, Jay L. Alberts, Cameron McIntyre, David D. Schindler
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Patent number: 9981123Abstract: One aspect of the present disclosure relates to lead assemblies for stimulating tissue. The lead assemblies can include lead bodies that are slidably coupled to each other and include one or more contacts that are moveably disposed within the slits of the lead bodies. The positions of the one or more contacts can be adjusted to change the direction of stimulation. For example, the positions of the one or more contacts can be adjusted based on theoretically-optimal positions determined from a patient-specific computer model. Parameters of the stimulation applied by the one or more contacts can also be optimized based on the patient-specific computer model.Type: GrantFiled: June 1, 2017Date of Patent: May 29, 2018Assignee: The Cleveland Clinic FoundationInventors: Andre G. Machado, Mark S. Lobosky, Karl West, Scott Lempka
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Publication number: 20180028807Abstract: This disclosure relates to using stereo-thermo-lesioning (STL) to create lesions at one or more locations in the patient's nervous system at the patient's bedside without general anesthesia. A method that uses STL to treat a patient's neurological condition includes: using a plurality of stereotactically-implanted thermo-coupled multi-contact electrodes to record conduction data within a predetermined theoretical zone of activity within the patient's neurological tissue; detecting abnormal neurological activity of a neurological condition within the conduction data and localize a portion of the predetermined theoretical zone of activity that is responsible for a primary organization of the abnormal neurological activity; creating a lesion at the portion of the predetermined theoretical zone of activity that is responsible for a primary organization of the abnormal neurological activity using at least one contact of the plurality of thermo-coupled multi-contact electrodes.Type: ApplicationFiled: July 26, 2017Publication date: February 1, 2018Inventors: Jorge A. Gonzalez-Martinez, John T. Gale, Andre G. Machado, Imad Najm
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Publication number: 20170266435Abstract: One aspect of the present disclosure relates to lead assemblies for stimulating tissue. The lead assemblies can include lead bodies that are slidably coupled to each other and include one or more contacts that are moveably disposed within the slits of the lead bodies. The positions of the one or more contacts can be adjusted to change the direction of stimulation. For example, the positions of the one or more contacts can be adjusted based on theoretically-optimal positions determined from a patient-specific computer model. Parameters of the stimulation applied by the one or more contacts can also be optimized based on the patient-specific computer model.Type: ApplicationFiled: June 1, 2017Publication date: September 21, 2017Inventors: Andre G. Machado, Mark S. Lobosky, Karl West, Scott Lempka
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Patent number: 9731117Abstract: One aspect of the present disclosure relates to lead assemblies for stimulating tissue. The lead assemblies can include lead bodies that are slid ably coupled to each other and include one or more contacts that are movably disposed within the slits of the lead bodies. The positions of the one or more contacts can be adjusted to change the direction of stimulation. For example, the positions of the one or more contacts can be adjusted based on theoretically-optimal positions determined from a patient-specific computer model. Parameters of the stimulation applied by the one or more contacts can also be optimized based on the patient-specific computer model.Type: GrantFiled: June 1, 2015Date of Patent: August 15, 2017Assignee: The Cleveland Clinic FoundationInventors: Andre G. Machado, Mark S. Lobosky, Karl West, Scott Lempka
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Patent number: 9672622Abstract: A system can include a model to represent a volumetric deformation of a brain corresponding to brain tissue that has been displaced by at least one of disease, surgery or anatomical changes. A fusion engine can perform a coarse and/or fine fusion to align a first image of the brain with respect to a second image of the brain after a region of the brain has been displaced and to employ the deformation model to adjust one or more points on a displacement vector extending through a displaced region of the brain to compensate for spatial deformations that occur between the first and second image of the brain.Type: GrantFiled: January 14, 2016Date of Patent: June 6, 2017Assignee: The Cleveland Clinic FoundationInventor: Andre G. Machado
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Patent number: 9463327Abstract: One aspect of the present disclosure relates a method for determining effective stimulation parameters to apply to a patient in order to improve the patient's medical condition. The method can employ functional and/or structural imaging to determine the effective stimulation parameters. As such, the method includes programming a stimulation device with an initial stimulation parameter. An image can be received of at least a portion of the patient that is affected by a stimulation by the stimulation device. Based on the image, the efficacy of the stimulation with the at least one initial stimulation parameter can be assessed. The at least one initial stimulation parameter can be updated based on the assessed efficacy.Type: GrantFiled: June 1, 2015Date of Patent: October 11, 2016Assignee: The Cleveland Clinic FoundationInventors: Scott Lempka, Andre G. Machado
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Publication number: 20160128621Abstract: This disclosure relates to a system and method to evaluate movement disorders. A movement data aggregator can combine data from a plurality of sensors into an aggregate movement data describing multi-dimensional movement of a handheld device. A calculator to compute an indication of a movement disorder based on the movement vector data and user input data, the user input data being generated in response to physical interaction between the handheld device and a human machine interface of a computing device/machine that is separate from the handheld device. In some examples, the handheld device can communicate with computing device via a wireless interface.Type: ApplicationFiled: November 12, 2015Publication date: May 12, 2016Inventors: Andre G. Machado, Jay L. Alberts, Cameron McIntyre, David D. Schindler
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Publication number: 20160133018Abstract: A system can include a model to represent a volumetric deformation of a brain corresponding to brain tissue that has been displaced by at least one of disease, surgery or anatomical changes. A fusion engine can perform a coarse and/or fine fusion to align a first image of the brain with respect to a second image of the brain after a region of the brain has been displaced and to employ the deformation model to adjust one or more points on a displacement vector extending through a displaced region of the brain to compensate for spatial deformations that occur between the first and second image of the brain.Type: ApplicationFiled: January 14, 2016Publication date: May 12, 2016Inventor: Andre G. Machado
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Patent number: 9269140Abstract: A system can include a model to represent a volumetric deformation of a brain corresponding to brain tissue that has been displaced by at least one of disease, surgery or anatomical changes. A fusion engine can perform a coarse and/or fine fusion to align a first image of the brain with respect to a second image of the brain after a region of the brain has been displaced and to employ the deformation model to adjust one or more points on a displacement vector extending through a displaced region of the brain to compensate for spatial deformations that occur between the first and second image of the brain.Type: GrantFiled: December 10, 2013Date of Patent: February 23, 2016Assignee: The Cleveland Clinic FoundationInventor: Andre G. Machado
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Publication number: 20150360039Abstract: One aspect of the present disclosure relates a method for determining effective stimulation parameters to apply to a patient in order to improve the patient's medical condition. The method can employ functional and/or structural imaging to determine the effective stimulation parameters. As such, the method includes programming a stimulation device with an initial stimulation parameter. An image can be received of at least a portion of the patient that is affected by a stimulation by the stimulation device. Based on the image, the efficacy of the stimulation with the at least one initial stimulation parameter can be assessed. The at least one initial stimulation parameter can be updated based on the assessed efficacy.Type: ApplicationFiled: June 1, 2015Publication date: December 17, 2015Inventors: Scott Lempka, Andre G. Machado
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Publication number: 20150343203Abstract: One aspect of the present disclosure relates to lead assemblies for stimulating tissue. The lead assemblies can include lead bodies that are slid ably coupled to each other and include one or more contacts that are movably disposed within the slits of the lead bodies. The positions of the one or more contacts can be adjusted to change the direction of stimulation. For example, the positions of the one or more contacts can be adjusted based on theoretically-optimal positions determined from a patient-specific computer model. Parameters of the stimulation applied by the one or more contacts can also be optimized based on the patient-specific computer model.Type: ApplicationFiled: June 1, 2015Publication date: December 3, 2015Inventors: Andre G. Machado, Mark S. Lobosky, Karl West, Scott Lempka
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Publication number: 20140161338Abstract: A system can include a model to represent a volumetric deformation of a brain corresponding to brain tissue that has been displaced by at least one of disease, surgery or anatomical changes. A fusion engine can perform a coarse and/or fine fusion to align a first image of the brain with respect to a second image of the brain after a region of the brain has been displaced and to employ the deformation model to adjust one or more points on a displacement vector extending through a displaced region of the brain to compensate for spatial deformations that occur between the first and second image of the brain.Type: ApplicationFiled: December 10, 2013Publication date: June 12, 2014Applicant: THE CLEVELAND CLINIC FOUNDATIONInventor: Andre G. Machado