Abstract: The present invention relates to a microneedle patch composition comprising one or more microneedles each comprising: (a) a tapered tip portion containing a therapeutically active ingredient dispersed in a matrix of a biodegradable polymer capable of providing sustained release of the therapeutically active ingredient over a period of at least two days after insertion of the microneedle or microneedles into the skin, and (b) a fast dissolving microneedle backing layer portion containing a water-soluble polymer overlayering the tip portion, said microneedle or microneedles being attached to and extending from an adhesive surface of a removable substrate.

Abstract: Methods, computer readable media, and devices for automated routing based on content metadata are provided. One method may include receiving a user request for content with metadata from a client by a content distribution network (CDN), parsing the user request for content to generate an evaluation of the metadata, determining a routing decision representing a selection of one of a plurality of origin services for the user request for content based on the evaluation of the metadata, transmitting the user request for content to the selected one of the plurality of origin services based on the routing decision, receiving a response to the user request for content from the selected one of the plurality of origin services, and sending the response to the client.

Abstract: Methods, computer readable media, and devices for automated routing based on content metadata are provided. One method may include receiving a user request for content with metadata from a client by a content distribution network (CDN), parsing the user request for content to generate an evaluation of the metadata, determining a routing decision representing a selection of one of a plurality of origin services for the user request for content based on the evaluation of the metadata, transmitting the user request for content to the selected one of the plurality of origin services based on the routing decision, receiving a response to the user request for content from the selected one of the plurality of origin services, and sending the response to the client.

Abstract: Methods, computer readable media, and devices for automated routing based on content metadata are provided. One method may include receiving a user request for content with metadata from a client by a content distribution network (CDN), parsing the user request for content to generate an evaluation of the metadata, determining a routing decision representing a selection of one of a plurality of origin services for the user request for content based on the evaluation of the metadata, transmitting the user request for content to the selected one of the plurality of origin services based on the routing decision, receiving a response to the user request for content from the selected one of the plurality of origin services, and sending the response to the client.

Abstract: Methods, computer readable media, and devices for efficient application programming interface (API) processing with privacy protection are disclosed herein. One method may include receiving a user request for content from a client, parsing the user request for content to identify one or more request portions having a type of public information, customized information, and personal information, transmitting the one or more request portions to a corresponding microservice based on the type of the portion of content being requested, receiving one or more response portions, determining a type of the one or more portions of content, and in response to determining the type of a portion of content is not personal information, caching the portion of content based on the type of the portion of content, combining the one or more response portions into a user response, and sending the user response to the client.

Abstract: Methods, computer readable media, and devices for automated routing based on content metadata are provided. One method may include receiving a user request for content with metadata from a client by a content distribution network (CDN), parsing the user request for content to generate an evaluation of the metadata, determining a routing decision representing a selection of one of a plurality of origin services for the user request for content based on the evaluation of the metadata, transmitting the user request for content to the selected one of the plurality of origin services based on the routing decision, receiving a response to the user request for content from the selected one of the plurality of origin services, and sending the response to the client.

Abstract: The present invention relates to a microneedle patch composition comprising one or more microneedles each comprising: (a) a tapered tip portion containing a therapeutically active ingredient dispersed in a matrix of a biodegradable polymer capable of providing sustained release of the therapeutically active ingredient over a period of at least two days after insertion of the microneedle or microneedles into the skin, and (b) a fast dissolving microneedle backing layer portion containing a water-soluble polymer overlayering the tip portion, said microneedle or microneedles being attached to and extending from an adhesive surface of a removable substrate.

Abstract: Novel aqueous topical gel compositions comprising ingenol-3-angelate.

Abstract: The invention relates to the treatment of actinic keratosis (AK) lesions using laser therapy followed by treatment with ingenol mebutate (e.g., PEP005 Gel).

Abstract: Topical gel composition comprising ingenol-3-angelate and a silicone.