Patents by Inventor Andre Iffland

Andre Iffland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mass spectrometry assays for identifying compounds that activate deacetylases
    Patent number: 8304206
    Abstract: Provided are methods for determining the activity of proteins that modulate the acetylation state of a protein substrate. The methods may be used for determining both acetyltransferase activity and deacetylase activity. The methods utilize mass spectrometry for determining the acetylation state of a substrate peptide. The methods may also be used to identify compounds that modulate the activity of a protein having acetyltransferase or deacetylase activity. In some embodiments, a compound that modulates a deacetylase is an activator of the deacetylase.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: November 6, 2012
    Assignee: Sirtris Pharmaceuticals, Inc.
    Inventors: Jesse Smith, Jill Milne, Amy Lynch, David Carney, Andre Iffland, Olivier Boss
  • BIOMARKERS OF SIRTUIN ACTIVITY AND METHODS OF USE THEREOF
    Publication number: 20100215632
    Abstract: Provided are methods for monitoring sirtuin modulation in a subject, for example, during therapeutic treatment with a sirtuin modulating compound. The methods involve determining the expression level of one or more sirtuin biomarkers in a biological sample from the subject. Also provided are methods for identifying compounds that modulate the activity of a sirtuin protein using one or more sirtuin biomarkers.
    Type: Application
    Filed: March 19, 2008
    Publication date: August 26, 2010
    Applicant: Sirtris Pharmaceuticals, Inc.
    Inventors: Olivier Boss, Siva Worcester, Andre Iffland, Jesse Smith, Jill Milne, Michael Jirousek
  • Mass Spectrometry Assays for Acetyltransferase/Deacetylase Activity
    Publication number: 20090221020
    Abstract: Provided are methods for determining the activity of proteins that modulate the acetylation state of a protein substrate. The methods may be used for determining both acetyltransferase activity and deacetylase activity. The methods utilize mass spectrometry for determining the acetylation state of a substrate peptide. The methods may also be used to identify compounds that modulate the activity of a protein having acetyltransferase or deacetylase activity.
    Type: Application
    Filed: December 1, 2006
    Publication date: September 3, 2009
    Applicant: Sirtris Pharmaceuticals, Inc
    Inventors: Jesse Smith, Jill Milne, Amy Lynch, David Carney, Andre Iffland, Olivier Boss
  • Sirtuin polymorphisms and methods of use thereof
    Publication number: 20080249103
    Abstract: Provided herein are methods for diagnosis and prognosis using polymorphic variants of sirtuins. Such polymorphic may be used, for example, to identify subjects that would be responsive to treatment with a sirtuin modulating compound and/or subjects that are suffering from or susceptible to a disease mediated by a sirtuin. Also provided are methods for determining the predictive value of a sirtuin polymorphic variant, methods for evaluating sirtuin modulating compounds, and methods for determining appropriate dosage and/or treatment regimens for subjects having one or more sirtuin polymorphic variants. Screening methods for identifying sirtuin modulating compounds using polymorphic variants of a sirtuin are also provided.
    Type: Application
    Filed: October 30, 2007
    Publication date: October 9, 2008
    Applicant: Sirtris Pharmaceuticals, Inc.
    Inventors: Markku Laakso, Teemu Kuulasmaa, Johan Auwerx, Christoph Westphal, Peter Elliott, Karl D. Normington, Olivier Boss, Andre Iffland, Siva Lavu