Patents by Inventor Andre J. Ouellette
Andre J. Ouellette has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7399823Abstract: The present invention relates to an isolated cyclic peptide, theta defensin, having antimicrobial activity, and to theta defensin analogs. A theta defensin can have the amino acid sequence Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa1-Xaa6-Xaa4-Xaa4-Xaa1-Xaa1-Xaa6-Xaa4-Xaa5-Xaa1-Xaa3-Xaa7-Xaa8, wherein Xaa1 to Xaa8 are defined; wherein Xaa1 can be linked through a peptide bond to Xaa8; and wherein crosslinks can be formed between Xaa3 and Xaa3, between Xaa5 and Xaa5, and between Xaa7 and Xaa7. For example, the invention provides a theta defensin having the amino acid sequence Gly-Phe-Cys-Arg-Cys-Leu-Cys-Arg-Arg-Gly-Val-Cys-Arg-Cys-Ile-Cys-Thr-Arg (SEQ ID NO:1), wherein the Gly at position 1 (Gly-1) is linked through a peptide bond to Arg-18, and wherein disulfide bonds are present between Cys-3 and Cys-16, between Cys-5 and Cys-14, and between Cys-7 and Cys-12. The invention also provides nucleic acids encoding theta defensins and antibodies that specifically bind a theta defensin.Type: GrantFiled: May 10, 2000Date of Patent: July 15, 2008Assignee: The Regents of the University of CaliforniaInventors: Michael E. Selsted, Yi-Quan Tang, Jun Yuan, Andre J. Ouellette
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Patent number: 6890537Abstract: The present invention relates to an isolated cyclic peptide, theta defensin, having antimicrobial activity, and to theta defensin analogs. A theta defensin can have the amino acid sequence Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa1-Xaa6-Xaa4-Xaa4-Xaa1-Xaa1-Xaa6-Xaa4-Xaa5-Xaa1-Xaa3-Xaa7-Xaa5, wherein Xaa1 to Xaa8 are defined; wherein Xaa1 can be linked through a peptide bond to Xaa8; and wherein crosslinks can be formed between Xaa3 and Xaa3, between Xaa5 and Xaa5, and between Xaa7 and Xaa7. For example, the invention provides a theta defensin having the amino acid sequence Gly-Phe-Cys-Arg-Cys-Leu-Cys-Arg-Arg-Gly-Val-Cys-Arg-Cys-Ile-Cys-Thr-Arg (SEQ ID NO:1), wherein the Gly at position 1 (Gly-1) is linked through a peptide bond to Arg-18, and wherein disulfide bonds are present between Cys-3 and Cys-16, between Cys-5 and Cys-14, and between Cys-7 and Cys-12. The invention also relates to antibodies that specifically bind a theta defensin and to isolated nucleic acid molecules encoding a theta defensin.Type: GrantFiled: December 5, 2002Date of Patent: May 10, 2005Assignee: The Regents of the University of CaliforniaInventors: Michael E. Selsted, Yi-Quan Tang, Jun Yuan, Andre J. Ouellette
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Publication number: 20030162718Abstract: The present invention relates to an isolated cyclic peptide, theta defensin, having antimicrobial activity, and to theta defensin analogs. A theta defensin can have the amino acid sequence Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa1-Xaa6-Xaa4-Xaa4-Xaa1-Xaa1-Xaa6-Xaa4-Xaa5-Xaa1-Xaa3-Xaa7-Xaa5, wherein Xaa1 to Xaa8 are defined; wherein Xaa1 can be linked through a peptide bond to Xaa8; and wherein crosslinks can be formed between Xaa3 and Xaa3, between Xaa5 and Xaa5, and between Xaa7 and Xaa7. For example, the invention provides a theta defensin having the amino acid sequence Gly-Phe-Cys-Arg-Cys-Leu-Cys-Arg-Arg-Gly-Val-Cys-Arg-Cys-Ile-Cys-Thr-Arg (SEQ ID NO:1), wherein the Gly at position 1 (Gly-1) is linked through a peptide bond to Arg-18, and wherein disulfide bonds are present between Cys-3 and Cys-16, between Cys-5 and Cys-14, and between Cys-7 and Cys-12. The invention also relates to antibodies that specifically bind a theta defensin and to isolated nucleic acid molecules encoding a theta defensin.Type: ApplicationFiled: December 5, 2002Publication date: August 28, 2003Applicant: The Regents of the University of CaliforniaInventors: Michael E. Selsted, Yi-Quan Tang, Jun Yuan, Andre J. Ouellette
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Patent number: 6514727Abstract: The present invention relates to an isolated cyclic peptide, theta defensin, having antimicrobial activity, and to theta defensin analogs. A theta defensin can have the amino acid sequence Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa1-Xaa6-Xaa4-Xaa4-Xaa1-Xaa1-Xaa6-Xaa4-Xaa5-Xaa1-Xaa3-Xaa7-Xaa5, wherein Xaa1 to Xaa8 are defined; wherein Xaa1 can be linked through a peptide bond to Xaa8; and wherein crosslinks can be formed between Xaa3 and Xaa3, between Xaa5 and Xaa5, and between Xaa7 and Xaa7. For example, the invention provides a theta defensin having the amino acid sequence Gly-Phe-Cys-Arg-Cys-Leu-Cys-Arg-Arg-Gly-Val-Cys-Arg-Cys-Ile-Cys-Thr-Arg (SEQ ID NO:1), wherein the Gly at position 1 (Gly-1) is linked through a peptide bond to Arg-18, and wherein disulfide bonds are present between Cys-3 and Cys-16, between Cys-5 and Cys-14, and between Cys-7 and Cys-12. The invention also relates to antibodies that specifically bind a theta defensin and to isolated nucleic acid molecules encoding a theta defensin.Type: GrantFiled: September 26, 2001Date of Patent: February 4, 2003Assignee: The Regents of the University of CaliforniaInventors: Michael E. Selsted, Yi-Quan Tang, Jun Yuan, Andre J. Ouellette
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Patent number: 6335318Abstract: The present invention relates to an isolated cyclic peptide, theta defensin, having antimicrobial activity, and to theta defensin analogs. A theta defensin can have the amino acid sequence Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa1-Xaa6-Xaa4-Xaa4-Xaa1-Xaa1-Xaa6-Xaa4-Xaa5 -Xaa1-Xaa3-Xaa7-Xaa5, wherein Xaa1 to Xaa8 are defined; wherein Xaa1 can be linked through a peptide bond to Xaa8; and wherein crosslinks can be formed between Xaa3 and Xaa3, between Xaa5 and Xaa5, and between Xaa7 and Xaa7. For example, the invention provides a theta defensin having the amino acid sequence Gly-Phe-Cys-Arg-Cys-Leu-Cys-Arg-Arg-Gly-Val-Cys-Arg-Cys-Ile-Cys-Thr-Arg (SEQ ID NO:1), wherein the Gly at position 1 (Gly-1) is linked through a peptide bond to Arg-18, and wherein disulfide bonds are present between Cys-3 and Cys-16, between Cys-5 and Cys-14, and between Cys-7 and Cys-12. The invention also relates to antibodies that specifically bind a theta defensin and to isolated nucleic acid molecules encoding a theta defensin.Type: GrantFiled: May 10, 1999Date of Patent: January 1, 2002Assignee: The Regents of the University of CaliforniaInventors: Michael E. Selsted, Yi-Quan Tang, Jun Yuan, Andre J. Ouellette
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Patent number: 6300470Abstract: The present invention provides substantially purified cryptdin peptides having a consensus amino acid sequence: X1-C-X2-C-R-X3-C-X4-E-X5-C-X6-C-C-X7 wherein X1 is 3 to 9 amino acids; X2 is one amino acid, preferably Y, H or R; X3 is 2 or 3 amino acids; X4 is three amino acids; X5 is five amino acids; X6 is 6 to 10 amino acids; and X7 is 0 to 9 amino acids.Type: GrantFiled: September 15, 1999Date of Patent: October 9, 2001Assignee: The Regents of the University of CaliforniaInventors: Michael E. Selsted, Andre J. Ouellette
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Patent number: 6057425Abstract: The present invention provides a method of preparing substantially purified cryptdin peptides having a consensus amino acid sequence:X.sub.1 -C-X.sub.2 -C-R-X.sub.3 -C-X.sub.4 -E-X.sub.5 -C-X.sub.6 -C-C-X.sub.7wherein X.sub.1 is 3 to 9 amino acids; X.sub.2 is one amino acid, preferably Y, H or R; X.sub.3 is 2 or 3 amino acids; X.sub.4 is three amino acids; X.sub.5 is five amino acids; X.sub.6 is 6 to 10 amino acids; and X.sub.7 is 0 to 9 amino acids. The invention also provides a method of preparing substantially purified mouse cryptdin having a consensus amino acid sequence:X.sub.1 -L-X.sub.2 -C-Y-C-R-X.sub.3 -C-K-X.sub.4 -E-X.sub.5 -G-T-C-X.sub.6 -C-C-X.sub.7wherein X.sub.1 is 3 or 4 amino acids, preferably LRD, LSKK (SEQ ID NO: 1) or LRG; X.sub.2 is 1 amino acid, preferably V, L or I; X.sub.3 is 3 amino acids, preferably KGH or *RG, where * is S, T, K, I or A; X.sub.4 is 2 amino acids, preferably GR, RR or RG; X.sub.5 is 3 amino acids, preferably RMN, RVR, RVF HMN or HIN; X.sub.Type: GrantFiled: January 30, 1998Date of Patent: May 2, 2000Assignee: The Regents of the University of CaliforniaInventors: Michael E. Selsted, Andre J. Ouellette
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Patent number: 5844072Abstract: The present invention provides substantially purified cryptdin peptides having a consensus amino acid sequence:X.sub.1 -C-X.sub.2 -C-R-X.sub.3 -C-X.sub.4 -E-X.sub.5 -C-X.sub.6 -C-C-X.sub.7or having a consensus amino acid sequence:X.sub.1 -L-X.sub.2 -C-Y-C-R-X.sub.3 -C-K-X.sub.4 -E-X.sub.5 -G-T-C-X.sub.6 -C-C-X.sub.7wherein X.sub.1 to X.sub.7 each independently is 0 to 10 amino acids. The invention also provides cryptdin analogs, which are devoid of one or more amino acids N-terminal to the first cysteine. In addition, the invention provides nucleic acid molecules encoding cryptdin peptides. The invention further provides methods for detecting inflammatory pathologies in a subject and for treating an inflammatory pathology in a subject by administering a pharmaceutical composition containing a cryptdin peptide.Type: GrantFiled: November 18, 1994Date of Patent: December 1, 1998Assignee: University of CaliforniaInventors: Michael E. Selsted, Andre J. Ouellette
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Patent number: 5840498Abstract: The present invention provides substantially purified cryptdin peptides having a consensus amino acid sequence:X.sub.1 -C-X.sub.2 -C-R-X.sub.3 -C-X.sub.4 -E-X.sub.5 -C-X.sub.6 -C-C-X.sub.7wherein X.sub.1 is 3 to 9 amino acids; X.sub.2 is one amino acid, preferably Y, H or R; X.sub.3 is 2 or 3 amino acids; X.sub.4 is three amino acids; X.sub.5 is five amino acids; X.sub.6 is 6 to 10 amino acids; and X.sub.7 is 0 to 9 amino acids. The invention also provides a substantially purified mouse cryptdin having a consensus amino acid sequence:X.sub.1 -L-X.sub.2 -C-Y-C-R-X.sub.3 -C-K-X.sub.4 -E-X.sub.5 -G-T-C-X.sub.6 -C-C-X.sub.7wherein X.sub.1 is 3 or 4 amino acids, preferably LRD, LSKK (SEQ ID NO: 1) or LRG; X.sub.2 is 1 amino acid, preferably V, L or I; X.sub.3 is 3 amino acids, preferably KGH or *RG, where * is S, T, K, I or A; X.sub.4 is 2 amino acids, preferably GR, RR or RG; X.sub.5 is 3 amino acids, preferably RMN, RVR, RVF HMN or HIN; X.sub.Type: GrantFiled: June 7, 1995Date of Patent: November 24, 1998Assignee: The Regents of the University of CaliforniaInventors: Michael E. Selsted, Andre J. Ouellette
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Patent number: 5731149Abstract: The present invention provides substantially purified cryptdin peptides having a consensus amino acid sequence:X.sub.1 --C--X.sub.2 --C--R--X.sub.3 --C--X.sub.4 --E--X.sub.5 --C--X.sub.6 --C--C--X.sub.7whereinX.sub.1 is 3 to 9 amino acids;X.sub.2 is one amino acid, preferably Y, H or R;X.sub.3 is 2 or 3 amino acids;X.sub.4 is three amino acids;X.sub.5 is five amino acids;X.sub.6 is 6 to 10 amino acids; andX.sub.7 is 0 to 9 amino acids.The invention also provides a substantially purified mouse cryptdin having a consensus amino acid sequence:X.sub.1 --L--X.sub.2 --C--Y--C--R--X.sub.3 --C--K--X.sub.4 --E--X.sub.5 --G--T--C--X.sub.6 --C--C--X.sub.7whereinX.sub.1 is 3 or 4 amino acids, preferably LRD, LSKK (SEQ ID NO: 1) or LRG;X.sub.2 is 1 amino acid, preferably V, L or I;X.sub.3 is 3 amino acids, preferably KGH or *RG, where * is S, T, K, I or A;X.sub.4 is 2 amino acids, preferably GR, RR or RG;X.sub.5 is 3 amino acids, preferably RMN, RVR, RVF HMN or HIN;X.sub.Type: GrantFiled: June 7, 1995Date of Patent: March 24, 1998Assignee: The Shriner's Hospital For Crippled ChildrenInventors: Michael E. Selsted, Andre J. Ouellette
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Patent number: 5422424Abstract: The present invention provides substantially purified cryptdin peptides having a consensus amino acid sequence as follows:X.sub.1 -C-X.sub.2 -C-R-X.sub.3 -C-X.sub.4 -E-X.sub.5 -G-X.sub.6 -C-X.sub.7 -C-C-X.sub.8wherein X.sub.1 is 3-6 amino acids; X.sub.2 is one amino acid; X.sub.3 is 2 or 3 amino acids; X.sub.4 is three amino acids; X.sub.5 is three amino acids; X.sub.6 is one amino acid; X.sub.7 is 6 to 10 amino acids; and X.sub.8 is 0 to 7 amino acids.The invention further provides substantially purified cryptdin peptides having a consensus amino acid sequence as follows:X.sub.1 -L-X.sub.2 -C-Y-C-R-X.sub.3 -C-K-X.sub.4 -E-R-X.sub.5 -G-T-C-X.sub.6 -C-C-X.sub.7wherein X.sub.1 is one to four amino acids; X.sub.2 is one amino acid; X.sub.3 is three amino acids; X.sub.4 is two amino acids; X.sub.5 is two amino acids; and X.sub.6 is six to nine amino acids; and X.sub.7 is zero to seven amino acids.Type: GrantFiled: August 14, 1992Date of Patent: June 6, 1995Assignees: The Regents of the University of California, The Shriner's Hospital for Crippled Children, The General Hospital CorporationInventors: Michael E. Selsted, Andre J. Ouellette, Samuel I. Miller