Abstract: The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

Abstract: A chemical vapor deposition method comprises flowing a carrier liquid through a reactor. A fluid comprising one or more reactants is introduced into the carrier liquid. The fluid is at a first temperature and first pressure and is sufficiently immiscible in the carrier liquid so as to form a plurality of microreactors suspended in the carrier liquid. Each of the microreactors comprise a discrete volume of the fluid and have a surface boundary defined by an interface of the fluid with the carrier liquid. The fluid is heated and optionally pressurized to a second temperature and second pressure at which a chemical vapor deposition reaction occurs within the microreactors to form a plurality of chemical vapor deposition products. The plurality of chemical vapor deposition products are separated from the carrier liquid. A system for carrying out the method of the present disclosure is also taught.

Abstract: Periods of interoperability of sideband buses prevent effective management of managed devices by a remote access controller. Embodiments avoid periods of inoperability of sideband buses and recover the sideband bus without resetting the managed devices or the IHS (Information Handling System). The remote access controller configures timer and transmits the timer to a managed device. The managed device monitors the sideband for messages for the remote access controller. If no messages are received before expiration of the timer, the managed device resets its sideband bus endpoint, without resetting the managed device.

Abstract: Periods of interoperability of sideband buses prevent effective management of managed devices by a remote access controller. Embodiments avoid periods of inoperability of sideband buses and recover the sideband bus without resetting the managed devices or the IHS (Information Handling System). The remote access controller configures timer and transmits the timer to a managed device. The managed device monitors the sideband for messages for the remote access controller. If no messages are received before expiration of the timer, the managed device resets its sideband bus endpoint, without resetting the managed device.

Abstract: A chemical vapor deposition method comprises flowing a carrier liquid through a reactor. A fluid comprising one or more reactants is introduced into the carrier liquid. The fluid is at a first temperature and first pressure and is sufficiently immiscible in the carrier liquid so as to form a plurality of microreactors suspended in the carrier liquid. Each of the microreactors comprise a discrete volume of the fluid and have a surface boundary defined by an interface of the fluid with the carrier liquid. The fluid is heated and optionally pressurized to a second temperature and second pressure at which a chemical vapor deposition reaction occurs within the microreactors to form a plurality of chemical vapor deposition products. The plurality of chemical vapor deposition products are separated from the carrier liquid. A system for carrying out the method of the present disclosure is also taught.

Abstract: A chemical vapor deposition method comprises flowing a carrier liquid through a reactor. A fluid comprising one or more reactants is introduced into the carrier liquid. The fluid is at a first temperature and first pressure and is sufficiently immiscible in the carrier liquid so as to form a plurality of microreactors suspended in the carrier liquid. Each of the microreactors comprise a discrete volume of the fluid and have a surface boundary defined by an interface of the fluid with the carrier liquid. The fluid is heated and optionally pressurized to a second temperature and second pressure at which a chemical vapor deposition reaction occurs within the microreactors to form a plurality of chemical vapor deposition products. The plurality of chemical vapor deposition products are separated from the carrier liquid. A system for carrying out the method of the present disclosure is also taught.

Abstract: A method for chemical vapor deposition on a substrate is disclosed. The method may include directing a process gas into a reaction chamber, and heating the process gas in the reaction chamber. Heating the process gas in the reaction chamber may decompose the process gas to thereby generate a plurality of decomposition products. The method may also include applying one or more biasing fields and/or waves to the process gas upstream of the substrate, and reacting the process gas with the substrate. The one or more biasing fields and/or waves may include electromagnetic waves, electric fields, and/or magnetic fields. The biasing fields and/or waves may urge at least a portion of the process gas towards or away from the substrate.

Abstract: A chemical vapor deposition method comprises flowing a carrier liquid through a reactor. A fluid comprising one or more reactants is introduced into the carrier liquid. The fluid is at a first temperature and first pressure and is sufficiently immiscible in the carrier liquid so as to form a plurality of microreactors suspended in the carrier liquid. Each of the microreactors comprise a discrete volume of the fluid and have a surface boundary defined by an interface of the fluid with the carrier liquid. The fluid is heated and optionally pressurized to a second temperature and second pressure at which a chemical vapor deposition reaction occurs within the microreactors to form a plurality of chemical vapor deposition products. The plurality of chemical vapor deposition products are separated from the carrier liquid. A system for carrying out the method of the present disclosure is also taught.

Abstract: A method for chemical vapor deposition on a substrate is disclosed. The method may include directing a process gas into a reaction chamber, and heating the process gas in the reaction chamber. Heating the process gas in the reaction chamber may decompose the process gas to thereby generate a plurality of decomposition products. The method may also include applying one or more biasing fields and/or waves to the process gas upstream of the substrate, and reacting the process gas with the substrate. The one or more biasing fields and/or waves may include electromagnetic waves, electric fields, and/or magnetic fields. The biasing fields and/or waves may urge at least a portion of the process gas towards or away from the substrate.

Abstract: The present invention provides peptidal fragments of human immunodeficiency virus (HIV) which interact specifically with a particular human leucocyte antigen (HLA) class I molecule to stimulate cytotoxic T lymphocyte immunity.

Abstract: A mixed device for successively generating in the earth, at the same location, longitudinal and shear waves is disclosed. The device comprises in association a target coupled to the earth surface and having a first striking face substantially parallel thereto and at least one second striking face substantially perpendicular to said first striking face. A guide tube is adapted to be positioned above the first striking face and perpendicularly thereto, and a movable weight is slidable in the guide tube and adapted to strike the first striking face. At least one hammer is articulated to a support rigidly secured to the guide tube and adapted to strike one second striking face of the target. Directional coupling means connect the guide tube to the target in such a manner that the weight sliding in the guide tube directly impinges the first striking face, but such that the guide tube is substantially released from the effect of the hammer impact on a second striking face.

Abstract: Multiple shocks of a vertically falling mass against a target member coupled with the earth are prevented by holding the mass and retaining it above the target member after its first bounce. This retention is accomplished by means of deformable elements laterally pressed against the mass body by jack rods actuated in response to a control signal produced by a sensor at the moment of the first impact of the mass.

Abstract: A mobile device is used which includes a target-member adapted for coupling to the earth and a means for striking the target- member so as to generate acoustic shear waves.The target-member is coupled to the earth through a deformable coupling member secured to the rigid frame of the target- member, the coupling being enhanced by the combination of a suction means and a network of channels arranged on the face of the coupling member which is in contact with the earth, whereby a partial vacuum is created between the coupling member and the earth.

Abstract: A mobile device for generating acoustic shear waves comprises a structure provided with at least one axle with wheels mounted thereon, said axle being displaceable with respect to at least a part of the structure.The mobile device has mounted thereon a target-member displaceable from a position suitable for transportation to a working position where it is in contact with the earth, and means for striking the target member, when in working position, by means of a mass, to produce an impact thereon.The target member is provided at its upper part with tracks for the wheels of the axle so that the wheels can be driven, by displacing the respective axles, from a position of contact with the earth to a position where they bear on the target member with the weight of at least a part of the structure.