Abstract: A method for modulating at least one pharmacokinetic property of an anti-angiogenic or blood disease or steroid therapeutic and efficacy upon administration to a host is provided. One administers to the host an effective amount of a bifunctional compound of less than about 5000 Daltons comprising the anti-angiogenic or blood disease or steroid therapeutic or an active derivative thereof and a pharmacokinetic modulating moiety. The pharmacokinetic modulating moiety binds to at least one intracellular protein. The bifunctional compound has at least one modulated pharmacokinetic property upon administration to the host as compared to a free drug control that comprises the anticancer therapeutic as well as enhanced efficacy not due to compound degradation. It is preferred that the pharmacokinetic modulating moiety has a mass of less than 1100 Daltons.

Abstract: A knowledge base having particular utility as a medical/pathology knowledge base contains textual and pictorial information on various diseases. The knowledge base includes user-selectable designations of diagnostic features which are characteristic of respective conditions to be diagnosed. These features comprise a case record and several case records are stored and retrieved for subsequent display of the features therein and of one or more pictorial images of those features. The pictorial images preferably are stored on a device such as an optical disk; and these pictorial images are linked to case records which may be stored in other storage devices, such as magnetic disk, whereby the retrieval of a case record accesses the linked pictorial images, whereby those pictorial images and features of the case record are displayed.