Abstract: A sorbent comprising a spherical, highly porous polymer with specific hydrophobic-hydrophilic properties, specific pore volume and its distribution, as well as a method of solid phase extraction using said sorbent. The sorbent is produced by suspension polymerization of at least one hydrophilic monomer and at least one hydrophobic monomer, where the hydrophilic monomer comprises an imidazole moiety and the hydrophobic monomer is a mixture of isomeric divinylbenzene monomers and isomeric ethylvinylbenzene monomers. The sorbent has a pore diameter range from 5 ? to 1000 ?, an average pore diameter of 50 ? to 250 ?, and a pore volume from 1 ml/g to 2 ml/g comprising 15% to 25% micropores, 50% to 80% mesopores, and 5% to 30% macropores. Solid phase extraction columns and plates packed with the sorbent of this invention provide reliable high recoveries for a broad spectrum of analytes with various polarity, even if the sorbent is dried out multiple times during the extraction.

Abstract: The invention relates to an adsorbent material, a method for cleaning blood and plasma and purifying albumin, and to a method for producing said adsorbent material. The inventive adsorbent material is embodied in the form of a highly cross-linked and porous spherical divinylbenzene copolymer which contains from 4 to 30 weight % of an imidazole derivative and at least 50 weight % of divinylvenzene incorporated by radical polymerization in the presence of air and/or oxygen. Said adsorbent material is embodied in such a way that it is biocompatible and suitable for removing free and albumin-bound toxic substances, drugs, pharmaceutical products, endogenic and exogenic toxins from blood, plasma, and external albumin circuits at a high rate and efficiency. The material is used in particular for adsorbing bilirubin and bile acids and is produced by suspension polymerization.