Patents by Inventor Andre Machado
Andre Machado has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140073994Abstract: This disclosure relates to a system and method to evaluate movement disorders. A movement data aggregator can combine data from a plurality of sensors into an aggregate movement data describing multi-dimensional movement of a handheld device. A calculator to compute an indication of a movement disorder based on the movement vector data and user input data, the user input data being generated in response to physical interaction between the handheld device and a human machine interface of a computing device/machine that is separate from the handheld device. In some examples, the handheld device can communicate with computing device via a wireless interface.Type: ApplicationFiled: September 11, 2013Publication date: March 13, 2014Applicant: The Cleveland Clinic FoundationInventors: Andre Machado, Jay L. Alberts, Cameron McIntyre, David Schindler
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Publication number: 20130338726Abstract: A neurostimulation system can include a memory, a playback system, a stimulation electrode, and a controller. The memory can store data for first and second input waveforms. The playback system can provides first and second output waveforms, based on the first and second input waveforms in the memory, respectively, to form composite patterns of stimulation or waveforms. The first output waveform can be different than the second output waveform. The second output waveform can be periodically superimposed on the first output waveform. The controller can be in communication with the stimulation electrode. The controller can be configured to control application of the composite pattern of stimulation or waveform to a target site in a body of a subject suffering from a medical condition.Type: ApplicationFiled: February 26, 2013Publication date: December 19, 2013Applicant: THE CLEVELAND CLINIC FOUNDATIONInventor: Andre Machado
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Publication number: 20130238068Abstract: Neuromodulation assemblies with lead bodies having curvatures that mimic the curvatures of the splenium, trunk, genu, or rostrum of the corpus callosum. Methods of stimulating the corpus callosum and methods of securing an electrical lead in the brain are also provided.Type: ApplicationFiled: April 5, 2013Publication date: September 12, 2013Applicant: THE CLEVELAND CLINIC FOUNDATIONInventors: Andre MACHADO, Ali R. REZAI
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Patent number: 8417345Abstract: Neuromodulation assemblies with lead bodies having curvatures that mimic the curvatures of the splenium, trunk, genu, or rostrum of the corpus callosum. Methods of stimulating the corpus callosum and methods of securing an electrical lead in the brain are also provided.Type: GrantFiled: March 4, 2010Date of Patent: April 9, 2013Assignee: The Cleveland Clinic FoundationInventors: Andre Machado, Ali R. Rezai
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Publication number: 20120136410Abstract: A method is provided for neuromodulation to treat stroke. One step of the method includes recording an input waveform from a first site in the nervous system in a source subject. The first site is healthy or at least partially functioning. Next, an output waveform is applied to a second site in the nervous system of a target subject suffering from the stoke. The second site is diseased due to the stroke.Type: ApplicationFiled: February 3, 2012Publication date: May 31, 2012Applicants: INTELECT MEDICAL, INC., The Cleveland Clinic FoundationInventors: Ali Rezai, Andre Machado, Keith Carlton
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Patent number: 8190263Abstract: Methods of treating various medical conditions by neuromodulation of target sites of a cerebello-thalamo-cortical pathway and/or a cortical-ponto-cerebellar pathway. Such medical conditions include unilateral motor deficits, movement disorders, psychiatric disorders, epilepsy, speech or cognitive deficits associated with hemispheric lesions, visual deficits associated with hemispheric lesions, learning disorders associated with hemispheric lesions, vertigo and/or dizziness, gait disturbances, hereditary/genetic disorders, congenital malformations, infectious disease, degenerative disorders, autoimmune disorders, and metabolic disorders. A method of enhancing memory, learning and/or cognitive capacity in a normal individual by stimulating a target site of a cerebello-thalamo-cortical pathway and/or a cortical-ponto-cerebellar pathway is also provided.Type: GrantFiled: November 12, 2009Date of Patent: May 29, 2012Assignee: The Cleveland Clinic FoundationInventors: Andre Machado, Ali Rezai
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Patent number: 8112154Abstract: Methods for neuromodulation using waveform signals. In certain embodiments, an input waveform is obtained from a signal source site in a source subject and an output waveform is applied to a target site in a target subject. The source subject is a human or animal and the signal source site is in the nervous system, including the brain. The source subject and target subject are the same subjects or different subjects. The output waveform is identical to the input waveform or derived from the input waveform. In some embodiments, the output waveform is modified in response to physiologic feedback. Also provided are systems for neuromodulation using waveform signals.Type: GrantFiled: November 20, 2007Date of Patent: February 7, 2012Assignee: The Cleveland Clinic FoundationInventors: Ali Rezai, Andre Machado, Keith Carlton
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Patent number: 7865237Abstract: Method of treating hemodynamic derangement and controlling the mobilization of splanchnic circulation. The method comprises applying a therapy signal to a celiac ganglion, a celiac plexus, a splanchnic nerve, or any combination thereof and adjusting the signal to effectuate treatment. The present invention also provides methods of treating hemodynamic derangement and controlling the mobilization of splanchnic circulation by transluminal modulation of the celiac ganglion, the celiac plexus, the splanchnic nerve.Type: GrantFiled: September 12, 2005Date of Patent: January 4, 2011Assignee: The Cleveland Clinic FoundationInventors: Sandra Machado, Ali Rezai, Andre Machado
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Publication number: 20100185269Abstract: Neuromodulation assemblies with lead bodies having curvatures that mimic the curvatures of the splenium, trunk, genu, or rostrum of the corpus callosum. Methods of stimulating the corpus callosum and methods of securing an electrical lead in the brain are also provided.Type: ApplicationFiled: March 4, 2010Publication date: July 22, 2010Applicant: THE CLEVELAND CLINIC FOUNDATIONInventors: Andre Machado, Ali R. Rezai
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Patent number: 7725196Abstract: Neuromodulation assemblies with lead bodies having curvatures that mimic the curvatures of the splenium, trunk, genu, or rostrum of the corpus callosum. Methods of stimulating the corpus callosum and methods of securing an electrical lead in the brain are also provided.Type: GrantFiled: May 4, 2005Date of Patent: May 25, 2010Assignee: The Cleveland Clinic FoundationInventors: Andre Machado, Ali R. Rezai
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Patent number: 7697991Abstract: Methods of treating various medical conditions by neuromodulation of a target site of interhemispheric fibers. Such medical conditions include unilateral motor deficits, movement disorders, psychiatric disorders, speech or cognitive deficits associated with hemispheric lesions, visual deficits associated with hemispheric lesions, hereditary/genetic disorders, congenital malformations, infection disease, degenerative disorder, autoimmune disorders, and metabolic disorders. A method of providing recovery and rehabilitation from states of reduced consciousness by neuromodulating a target site of interhemispheric fibers is also provided.Type: GrantFiled: May 4, 2005Date of Patent: April 13, 2010Assignee: The Cleveland Clinic FoundationInventors: Andre Machado, Ali R. Rezai
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Publication number: 20100057161Abstract: Methods of treating various medical conditions by neuromodulation of target sites of a cerebello-thalamo-cortical pathway and/or a cortical-ponto-cerebellar pathway. Such medical conditions include unilateral motor deficits, movement disorders, psychiatric disorders, epilepsy, speech or cognitive deficits associated with hemispheric lesions, visual deficits associated with hemispheric lesions, learning disorders associated with hemispheric lesions, vertigo and/or dizziness, gait disturbances, hereditary/genetic disorders, congenital malformations, infectious disease, degenerative disorders, autoimmune disorders, and metabolic disorders. A method of enhancing memory, learning and/or cognitive capacity in a normal individual by stimulating a target site of a cerebello-thalamo-cortical pathway and/or a cortical-ponto-cerebellar pathway is also provided.Type: ApplicationFiled: November 12, 2009Publication date: March 4, 2010Inventors: Andre Machado, Ali R. Rezai
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Patent number: 7640063Abstract: Methods of treating various medical conditions by neuromodulation of target sites of a cerebello-thalamo-cortical pathway and/or a cortical-ponto-cerebellar pathway. Such medical conditions include unilateral motor deficits, movement disorders, psychiatric disorders, epilepsy, speech or cognitive deficits associated with hemispheric lesions, visual deficits associated with hemispheric lesions, learning disorders associated with hemispheric lesions, vertigo and/or dizziness, gait disturbances, hereditary/genetic disorders, congenital malformations, infectious disease, degenerative disorders, autoimmune disorders, and metabolic disorders. A method of enhancing memory, learning and/or cognitive capacity in a normal individual by stimulating a target site of a cerebello-thalamo-cortical pathway and/or a cortical-ponto-cerebellar pathway is also provided.Type: GrantFiled: May 4, 2005Date of Patent: December 29, 2009Assignee: The Cleveland Clinic FoundationInventors: Ali R. Rezai, Andre Machado
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Patent number: 7532938Abstract: A minimally invasive intraluminal electrode assembly that includes a cannulated tube and a plurality of wires disposed within the cannulated tube. Each of the plurality of wires has one of a plurality of electrical contacts on a distal end thereof. The distal portion of the plurality of wires assumes a radially constrained configuration within the cannulated tube in a retracted position and a radially extended position outward of the cannulated tube in a deployed position. The electrode assembly further comprises a spring electrode connecting the plurality of electrical contacts to collectively form a substantially circular configuration in a deployed position.Type: GrantFiled: September 12, 2005Date of Patent: May 12, 2009Assignee: The Cleveland Clinic FoundationInventors: Sandra Machado, Andre Machado, Ali Rezai
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Publication number: 20080208284Abstract: Methods for neuromodulation using waveform signals. In certain embodiments, an input waveform is obtained from a signal source site in a source subject and an output waveform is applied to a target site in a target subject. The source subject is a human or animal and the signal source site is in the nervous system, including the brain. The source subject and target subject are the same subjects or different subjects. The output waveform is identical to the input waveform or derived from the input waveform. In some embodiments, the output waveform is modified in response to physiologic feedback. Also provided are systems for neuromodulation using waveform signals.Type: ApplicationFiled: November 20, 2007Publication date: August 28, 2008Applicants: THE CLEVELAND CLINIC FOUNDATION, INTELECT MEDICAL,INC.Inventors: Ali Rezai, Andre Machado, Keith Carlton
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Publication number: 20060100667Abstract: Method of treating hemodynamic derangement and controlling the mobilization of splanchnic circulation. The method comprises applying a therapy signal to a celiac ganglion, a celiac plexus, a splanchnic nerve, or any combination thereof and adjusting the signal to effectuate treatment. The present invention also provides methods of treating hemodynamic derangement and controlling the mobilization of splanchnic circulation by transluminal modulation of the celiac ganglion, the celiac plexus, the splanchnic nerve.Type: ApplicationFiled: September 12, 2005Publication date: May 11, 2006Inventors: Sandra Machado, Ali Rezai, Andre Machado
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Publication number: 20060058597Abstract: A minimally invasive intraluminal electrode assembly that includes a cannulated tube and a plurality of wires disposed within the cannulated tube. Each of the plurality of wires has one of a plurality of electrical contacts on a distal end thereof. The distal portion of the plurality of wires assumes a radially constrained configuration within the cannulated tube in a retracted position and a radially extended position outward of the cannulated tube in a deployed position. The electrode assembly further comprises a spring electrode connecting the plurality of electrical contacts to collectively form a substantially circular configuration in a deployed position.Type: ApplicationFiled: September 12, 2005Publication date: March 16, 2006Inventors: Andre Machado, Ali Rezai
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Publication number: 20050288760Abstract: Neuromodulation assemblies with lead bodies having curvatures that mimic the curvatures of the splenium, trunk, genu, or rostrum of the corpus callosum. Methods of stimulating the corpus callosum and methods of securing an electrical lead in the brain are also provided.Type: ApplicationFiled: May 4, 2005Publication date: December 29, 2005Inventors: Andre Machado, Ali Rezai
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Publication number: 20050283200Abstract: Methods of treating various medical conditions by neuromodulation of target sites of a cerebello-thalamo-cortical pathway and/or a cortical-ponto-cerebellar pathway. Such medical conditions include unilateral motor deficits, movement disorders, psychiatric disorders, epilepsy, speech or cognitive deficits associated with hemispheric lesions, visual deficits associated with hemispheric lesions, learning disorders associated with hemispheric lesions, vertigo and/or dizziness, gait disturbances, hereditary/genetic disorders, congenital malformations, infectious disease, degenerative disorders, autoimmune disorders, and metabolic disorders. A method of enhancing memory, learning and/or cognitive capacity in a normal individual by stimulating a target site of a cerebello-thalamo-cortical pathway and/or a cortical-ponto-cerebellar pathway is also provided.Type: ApplicationFiled: May 4, 2005Publication date: December 22, 2005Inventors: Ali Rezai, Andre Machado
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Publication number: 20050283201Abstract: Methods of treating various medical conditions by neuromodulation of a target site of interhemispheric fibers. Such medical conditions include unilateral motor deficits, movement disorders, psychiatric disorders, speech or cognitive deficits associated with hemispheric lesions, visual deficits associated with hemispheric lesions, hereditary/genetic disorders, congenital malformations, infection disease, degenerative disorder, autoimmune disorders, and metabolic disorders. A method of providing recovery and rehabilitation from states of reduced consciousness by neuromodulating a target site of interhemispheric fibers is also provided.Type: ApplicationFiled: May 4, 2005Publication date: December 22, 2005Inventors: Andre Machado, Ali Rezai