Patents by Inventor Andre Mercanzini
Andre Mercanzini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11766560Abstract: Described herein are microelectrode array devices, and methods of fabrication, assembly and use of the same, to provide highly localized neural recording and/or neural stimulation to a neurological target. The device includes multiple microelectrode elements arranged protruding shafts. The protruding shafts are enclosed within an elongated probe shaft, and can be expanded from their enclosure. The microelectrode elements, and elongated probe shafts, are dimensioned in order to target small volumes of neurons located within the nervous system, such as in the deep brain region. Beneficially, the probe can be used to quickly identify the location of a neurological target, and remain implanted for long-term monitoring and/or stimulation.Type: GrantFiled: June 12, 2020Date of Patent: September 26, 2023Inventors: André Mercanzini, Philippe Renaud, Claudio Pollo
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Patent number: 11738192Abstract: The present disclosure describes an implantable lead device that includes an internal support comb. The support comb can include one or more faces that enable the alignment, routing, and holding of the lead device's internal wires. The support comb can enable the interconnection of the wires with to the microelectrode film that includes the lead device's electrodes.Type: GrantFiled: February 8, 2022Date of Patent: August 29, 2023Inventors: André Mercanzini, Zbynek Struzka, Jason Jinyu Ruan, Pascal Harbi, Alain Jordan
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Patent number: 11730953Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.Type: GrantFiled: October 13, 2021Date of Patent: August 22, 2023Inventors: André Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
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Publication number: 20220266024Abstract: The present disclosure describes systems and methods for recording electrical activity, such as local field potentials. The system can include a recording patch that is placed inline between an implanted neurological lead and an implantable pulse stimulator. The recording patch can include recording and amplification circuitry that detects, records, and amplifies electrical activity (also referred to as signals) from a target site. The system can be used to select over which of the lead's electrodes therapeutic stimulations are delivered.Type: ApplicationFiled: May 10, 2022Publication date: August 25, 2022Applicant: ALEVA NEUROTHERAPEUTICSInventors: Andre Mercanzini, Alain Dransart, Khoa Nguyen
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Patent number: 11344728Abstract: The present disclosure describes systems and methods for recording electrical activity, such as local field potentials. The system can include a recording patch that is placed inline between an implanted neurological lead and an implantable pulse stimulator. The recording patch can include recording and amplification circuitry that detects, records, and amplifies electrical activity (also referred to as signals) from a target site. The system can be used to select over which of the lead's electrodes therapeutic stimulations are delivered.Type: GrantFiled: May 28, 2019Date of Patent: May 31, 2022Assignee: ALEVA NEUROTHERAPEUTICSInventors: Andre Mercanzini, Alain Dransart, Khoa Nguyen
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Publication number: 20220161024Abstract: The present disclosure describes an implantable lead device that includes an internal support comb. The support comb can include one or more faces that enable the alignment, routing, and holding of the lead device's internal wires. The support comb can enable the interconnection of the wires with to the microelectrode film that includes the lead device's electrodes.Type: ApplicationFiled: February 8, 2022Publication date: May 26, 2022Applicant: Aleva NeurotherapeuticsInventors: André MERCANZINI, Zbynek STRUZKA, Jason Jinyu RUAN, Pascal HARBI, Alain JORDAN
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Patent number: 11311718Abstract: Described herein are microelectrode devices to provide localized neural recording or neural stimulation to a neurological target. The device includes a plurality of electrodes disposed along the shafts of deployable flexible pins. The deployable flexible pins are enclosed within an elongated probe shaft and can be expanded from their enclosure. Additionally, a specifically manufactured outer housing can be coupled to at least a portion of the elongated probe shaft. During deployment of the flexible pins the outer housing of the microelectrode device reduces friction between the flexible pins and the probe shaft and reduces delamination of the flexible pins during deployment.Type: GrantFiled: April 9, 2019Date of Patent: April 26, 2022Assignee: ALEVA NEUROTHERAPEUTICS SAInventors: Marc Boers, Andre Mercanzini, Jean-Michel Dougoud, Alexandre Michalis, Khoa Nguyen
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Patent number: 11266830Abstract: The present disclosure describes an implantable lead device that includes an internal support comb. The support comb can include one or more faces that enable the alignment, routing, and holding of the lead device's internal wires. The support comb can enable the interconnection of the wires with to the microelectrode film that includes the lead device's electrodes.Type: GrantFiled: June 15, 2020Date of Patent: March 8, 2022Assignee: ALEVA NEUROTHERAPEUTICSInventors: Andre Mercanzini, Zbynek Struzka, Jason Jinyu Ruan, Pascal Harbi, Alain Jordan
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Publication number: 20220032043Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.Type: ApplicationFiled: October 13, 2021Publication date: February 3, 2022Applicant: Aleva NeurotherapeuticsInventors: André MERCANZINI, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
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Patent number: 11167126Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.Type: GrantFiled: August 26, 2019Date of Patent: November 9, 2021Assignee: ALEVA NEUROTHERAPEUTICSInventors: André Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
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Patent number: 11160975Abstract: The present disclosure discusses a nerve cuff that includes a thin-film elastic mesh with an integrated array of electrodes. The nerve cuff can wrap around a human carotid artery or other tissue to stimulate the autonomic nervous system. The nerve cuff can include a housing that secures the mesh to the carotid artery or other tissue.Type: GrantFiled: February 28, 2019Date of Patent: November 2, 2021Assignee: ALEVA NEUROTHERAPEUTICSInventors: Andre Mercanzini, Zbynek Struzka, Jason Jinyu Ruan
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Patent number: 11123548Abstract: Described herein are microelectrode array devices, and methods of fabrication and use of the same, to provide highly localized and efficient electrical stimulation of a neurological target. The device includes multiple microelectrode elements arranged along an elongated probe shaft. The microelectrode elements are dimensioned and shaped so as to target individual neurons, groups of neurons, and neural tissue as may be located in an animal nervous system, such as deep within a human brain. Beneficially, the neurological probe can be used to facilitate location of the neurological target and remain implanted for long-term monitoring and/or stimulation.Type: GrantFiled: August 5, 2019Date of Patent: September 21, 2021Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNEInventors: Andre Mercanzini, Philippe Renaud
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Patent number: 10966620Abstract: Described herein are microelectrode devices to provide localized neural recording or neural stimulation to a neurological target. The device includes a plurality of electrodes disposed along the shafts of deployable flexible pins. The deployable flexible pins are enclosed within an elongated probe shaft, and can be expanded from their enclosure. Additionally, a specifically manufactured outer housing can be coupled to at least a portion of the elongated probe shaft. During deployment of the flexible pins the outer housing of the microelectrode device reduces friction between the flexible pins and the probe shaft and reduces delamination of the flexible pins during deployment.Type: GrantFiled: May 15, 2015Date of Patent: April 6, 2021Assignee: Aleva Neurotherapeutics SAInventors: Marc Boers, Andre Mercanzini, Jean-Michel Dougoud, Alexandre Michalis
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Patent number: 10952627Abstract: A preferred frequency is identified, being usable to stimulate a neurological target within a mammalian body using at least one microelectrode positioned at or near the target. To establish efficient and effective stimulation, an impedance analyzer is provided for measuring electrical impedance values indicative of a microelectrode-tissue interface across a range of different frequencies. A preferred one of the measured electrical impedance values is identified as being closest to a pure resistance. The neurological target can then be stimulated at or near the frequency associated with the preferred impedance value (peak resistance frequency), thereby promoting desirable traits, such as optimum charge transfer, minimum signal distortion, increased stimulation efficiency, and prevention of microelectrode corrosion. The peak resistance frequency can be used to determine an preferred pulse shape.Type: GrantFiled: December 31, 2018Date of Patent: March 23, 2021Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNEInventors: André Mercanzini, Philippe Renaud
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Publication number: 20200376276Abstract: The present disclosure describes systems and methods for recording electrical activity, such as local field potentials. The system can include a recording patch that is placed inline between an implanted neurological lead and an implantable pulse stimulator. The recording patch can include recording and amplification circuitry that detects, records, and amplifies electrical activity (also referred to as signals) from a target site. The system can be used to select over which of the lead's electrodes therapeutic stimulations are delivered.Type: ApplicationFiled: May 28, 2019Publication date: December 3, 2020Inventors: Andre Mercanzini, Alain Dransart, Khoa Nguyen
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Publication number: 20200306524Abstract: The present disclosure describes an implantable lead device that includes an internal support comb. The support comb can include one or more faces that enable the alignment, routing, and holding of the lead device's internal wires. The support comb can enable the interconnection of the wires with to the microelectrode film that includes the lead device's electrodes.Type: ApplicationFiled: June 15, 2020Publication date: October 1, 2020Inventors: Andre Mercanzini, Zbynek Struzka, Jason Jinyu Ruan, Pascal Harbi, Alain Jordan
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Publication number: 20200306523Abstract: Described herein are microelectrode array devices, and methods of fabrication, assembly and use of the same, to provide highly localized neural recording and/or neural stimulation to a neurological target. The device includes multiple microelectrode elements arranged protruding shafts. The protruding shafts are enclosed within an elongated probe shaft, and can be expanded from their enclosure. The microelectrode elements, and elongated probe shafts, are dimensioned in order to target small volumes of neurons located within the nervous system, such as in the deep brain region. Beneficially, the probe can be used to quickly identify the location of a neurological target, and remain implanted for long-term monitoring and/or stimulation.Type: ApplicationFiled: June 12, 2020Publication date: October 1, 2020Inventors: André MERCANZINI, Philippe RENAUD, Claudio POLLO
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Patent number: 10702692Abstract: The present disclosure describes an implantable lead device that includes an internal support comb. The support comb can include one or more faces that enable the alignment, routing, and holding of the lead device's internal wires. The support comb can enable the interconnection of the wires with to the microelectrode film that includes the lead device's electrodes.Type: GrantFiled: March 2, 2018Date of Patent: July 7, 2020Assignee: ALEVA NEUROTHERAPEUTICSInventors: Andre Mercanzini, Zbynek Struzka, Jason Jinyu Ruan, Pascal Harbi, Alain Jordan
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Patent number: 10695556Abstract: Described herein are microelectrode array devices, and methods of fabrication, assembly and use of the same, to provide highly localized neural recording and/or neural stimulation to a neurological target. The device includes multiple microelectrode elements arranged protruding shafts. The protruding shafts are enclosed within an elongated probe shaft, and can be expanded from their enclosure. The microelectrode elements, and elongated probe shafts, are dimensioned in order to target small volumes of neurons located within the nervous system, such as in the deep brain region. Beneficially, the probe can be used to quickly identify the location of a neurological target, and remain implanted for long-term monitoring and/or stimulation.Type: GrantFiled: December 5, 2016Date of Patent: June 30, 2020Assignee: Ecole Polytechnique Federale de LausanneInventors: André Mercanzini, Philippe Renaud, Claudio Pollo
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Publication number: 20200009372Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.Type: ApplicationFiled: August 26, 2019Publication date: January 9, 2020Inventors: André MERCANZINI, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart