Abstract: A system is configured to: (a) receive multi-modal data from one or more sources; (b) analyze the data to determine features; (c) store the features in a database; (d) receive a search query for searching the stored features; (e) analyze the search query using a large language model to extract search features; (f) generate search results from the search features; and (g) display search results on a standardized graphical user interface including a legend having at least one or more of the search features displayed.

Abstract: A radar device for limiting radio-frequency power leakage is provided. The radar device includes a first component, and a second component. The first component has a first surface and a first waveguide that defines a first cavity. The second component has a second surface and a second waveguide that defines a second cavity. A first groove is provided that acts as a choke, and the first groove is defined in the first surface. The first component and the second component are assembled so that an air gap is maintained between the first waveguide and the second waveguide. The first waveguide and the second waveguide are configured to facilitate transmission of radio-frequency power. The first groove is configured to reduce leakage of radio-frequency power through the air gap. Additional chokes may also be included.

Abstract: A system is configured to: (a) receive multi-modal data from one or more sources; (b) analyze the data to determine features; (c) store the features in a database; (d) receive a search query for searching the stored features; (e) analyze the search query using a large language model to extract search features; (f) generate search results from the search features; and (g) display search results on a standardized graphical user interface including a legend having at least one or more of the search features displayed.

Abstract: A system is configured to: (a) receive multi-modal data from one or more sources; (b) analyze the data to determine features; (c) store the features in a database; (d) receive a search query for searching the stored features; (e) analyze the search query using a large language model to extract search features; (f) generate search results from the search features; and (g) display search results on a standardized graphical user interface including a legend having at least one or more of the search features displayed.

Abstract: A system is configured to: (a) receive multi-modal data from one or more sources, the multi-modal data including text data; (b) analyze the data to determine features; (c) store the features in a database; (d) receive a search query for searching the stored features; (e) analyze the search query using a large language model to extract search features; (f) generate search results from the search features; and (g) display search results on a standardized graphical user interface including (i) a map and (ii) a legend having at least one or more of the search features displayed.

Abstract: A real time assay monitoring system and method can be used to monitor reagent volume in assays for fluid replenishment control, monitor assays in real-time to obtain quality control information, monitor assays in real-time during development to detect saturation levels that can be used to shorten assay time, and provide assay results before the assay is complete, enabling reflex testing to begin automatically. The monitoring system can include a real time imaging system with a camera and lights to capture images of the assay. The captured images can then be used to monitor and control the quality of the staining process in an assay, provide early assay results, and/or to measure the on-site reagent volume within the assay.

Abstract: A digital microphone includes a first modulation path having an input for receiving an analog input signal and an output for generating a first digital signal; a second modulation path having an input for receiving the analog input signal and an output for generating a second digital signal; a summing circuit having a first input for receiving the first digital signal, a second input for receiving the second digital signal, and an output for generating a digital calibration path signal; and a difference circuit having a first input for receiving the first digital signal, a second input for receiving the second digital signal, and an output for generating a digital signal path signal.

Abstract: Provided herein are bispecific antigen-binding molecules that bind HER2 and methods of use thereof. The bispecific antigen-binding molecules comprise a first and a second antigen-binding domain, wherein the first and second antigen-binding domains bind to two different (preferably nonoverlapping) epitopes of the extracellular domain of human HER2. The bispecific antigen-binding molecules cluster on the surface of HER2 IHC2+ and IHC3+ cells, and are internalized into the cellular lysosomes. Also included are antibody-drug conjugates (ADCs) comprising the antibodies or bispecific antigen-binding molecules provided herein linked to a cytotoxic agent, radionuclide, or other moiety, as well as methods of treating cancer in a subject by administering to the subject a bispecific antigen-binding molecule or an ADC thereof.

Abstract: The protein known as human epidermal growth factor 2 (HER2) is expressed in breast cancer cells and its expression is correlated with aggressive tumor growth. The present invention provides novel full-length human (IgG) antibodies that bind to human HER2 (monospecific antibodies) or to APLP2 (monospecific antibodies). The present invention also provides novel bispecific antibodies (bsAbs) that bind to both HER2 and APLP2 and mediate internalization and degradation of HER2 via the APLP2 complex in the presence of HER2-expressing tumors. Described are bispecific antigen-binding molecules and ADCs comprising a first antigen-binding domain that specifically binds human APLP2, and a second antigen-binding domain that specifically binds human HER2.

Abstract: Provided herein are bispecific antigen-binding molecules that bind HER2 and methods of use thereof. The bispecific antigen-binding molecules comprise a first and a second antigen-binding domain, wherein the first and second antigen-binding domains bind to two different (preferably non-overlapping) epitopes of the extracellular domain of human HER2. The bispecific antigen-binding molecules cluster on the surface of HER2 IHC2+ and IHC3+ cells, and are internalized into the cellular lysosomes. Also included are antibody-drug conjugates (ADCs) comprising the antibodies or bispecific antigen-binding molecules provided herein linked to a cytotoxic agent, radionuclide, or other moiety, as well as methods of treating cancer in a subject by administering to the subject a bispecific antigen-binding molecule or an ADC thereof.

Abstract: A real time assay monitoring system and method can be used to monitor reagent volume in assays for fluid replenishment control, monitor assays in real-time to obtain quality control information, monitor assays in real-time during development to detect saturation levels that can be used to shorten assay time, and provide assay results before the assay is complete, enabling reflex testing to begin automatically. The monitoring system can include a real time imaging system with a camera and lights to capture images of the assay. The captured images can then be used to monitor and control the quality of the staining process in an assay, provide early assay results, and/or to measure the on-site reagent volume within the assay.

Abstract: A housing part, in particular a lower housing part, of an energy storage housing, has two mutually spaced longitudinal elements which run in parallel with one another and extend in a longitudinal direction. The longitudinal elements are connected at end faces via transverse elements. A planar base element is fastened to the longitudinal elements. The longitudinal elements have contact regions which are oriented towards the base element, by which contact regions the base element is fastened to the longitudinal elements. Three weld seams extending in the longitudinal direction are formed in each of the contact regions.

Abstract: A voltage-controlled oscillator analog-to-digital converter (VCO-ADC) includes a first source follower coupled between a first input terminal and a first internal node; a first VCO having an input coupled to a second internal node; a first variable resistor coupled between the first internal node and the second internal node; and a digital signal processing component coupled between an output of the first VCO and a output terminal.

Abstract: Autonomous control of a subject vehicle including a longitudinal motion control system includes determining states of parameters associated with a trajectory for the subject vehicle and parameters associated with a control reference determined for the subject vehicle. A range control routine is executed to determine a first parameter associated with a range control command based upon the states of the plurality of parameters, and a speed control routine is executed to determine a second parameter associated with a speed control command based upon the states of the plurality of parameters. An arbitration routine is executed to evaluate the range control command and the speed control command, and operation of the subject vehicle is controlled to achieve a desired longitudinal state, wherein the desired longitudinal state is associated with a minimum of the range control command and the speed control command.

Abstract: A radar device for limiting radio-frequency power leakage is provided. The radar device includes a first component, and a second component. The first component has a first surface and a first waveguide that defines a first cavity. The second component has a second surface and a second waveguide that defines a second cavity. A first groove is provided that acts as a choke, and the first groove is defined in the first surface. The first component and the second component are assembled so that an air gap is maintained between the first waveguide and the second waveguide. The first waveguide and the second waveguide are configured to facilitate transmission of radio-frequency power. The first groove is configured to reduce leakage of radio-frequency power through the air gap. Additional chokes may also be included.

Abstract: A voltage-controlled oscillator analog-to-digital converter (VCO-ADC) includes a first source follower coupled between a first input terminal and a first internal node; a first VCO having an input coupled to a second internal node; a first variable resistor coupled between the first internal node and the second internal node; and a digital signal processing component coupled between an output of the first VCO and a output terminal.

Abstract: An automotive vehicle includes a vehicle-based charging unit including a receiving unit configured to receive power from a ground-based charging unit, the receiving unit including a multi-coil receiver, a first actuator operably coupled to the vehicle-based charging unit and configured to adjust a first position of the vehicle-based charging unit relative to the ground-based charging unit, and a controller configured to selectively actuate the first actuator.

Abstract: An analog-to-digital converter includes a voltage-controlled oscillator (VCO) having an input for receiving an analog input signal; a double binary counter having a first input coupled to a first output of the VCO, a second input coupled to a second output of the VCO; a first set of registers coupled to the first output of the double binary counter; a second set of registers coupled to the second output of the double binary counter; sense amplifiers coupled to the outputs of the VCO; and a correction component coupled to the first set of registers, the second set of registers, and the sense amplifiers, wherein the correction component generates a coarse count, a fine count, and combines the coarse count and the fine count to provide a digital output signal representative of the analog input signal.

Abstract: A vehicle including a Global Positioning System (GPS) sensor, an Inertial Measurement Unit (IMU), and an Advanced Driver Assistance System (ADAS) is described. Operating the vehicle includes determining, via the GPS sensor, first parameters associated with a velocity, a position, and a course, and determining, via the IMU, second parameters associated with acceleration and angular velocity. Roll and pitch parameters are determined based upon the first and second parameters. A first vehicle velocity vector is determined based upon the roll and pitch parameters, the first parameters, and the second parameters; and a second vehicle velocity vector is determined based upon the roll and pitch parameters, road surface friction coefficient, angular velocity, road wheel angles and the first vehicle velocity vector. A final vehicle velocity vector is determined based upon fusion of the first and second vehicle velocity vectors. The vehicle is controlled based upon the final vehicle velocity vector.