Abstract: Provided herein are bispecific antigen-binding molecules that bind HER2 and methods of use thereof. The bispecific antigen-binding molecules comprise a first and a second antigen-binding domain, wherein the first and second antigen-binding domains bind to two different (preferably non-overlapping) epitopes of the extracellular domain of human HER2. The bispecific antigen-binding molecules cluster on the surface of HER2 IHC2+ and IHC3+ cells, and are internalized into the cellular lysosomes. Also included are antibody-drug conjugates (ADCs) comprising the antibodies or bispecific antigen-binding molecules provided herein linked to a cytotoxic agent, radionuclide, or other moiety, as well as methods of treating cancer in a subject by administering to the subject a bispecific antigen-binding molecule or an ADC thereof.

Abstract: An outer platform leading edge cooling system includes a radially outer platform having a platform leading edge; a hollow cooling channel is defined extending generally longitudinally along the platform leading edge of the radially outer platform; an inlet port located in a radially outer end region of the platform leading edge being fluidly coupled with the hollow cooling channel; and the hollow cooling channel comprising an outlet conduit extending from a cooling channel exit, the outlet conduit being connected in fluid flow communication with a trailing edge cavity.

Abstract: A real time assay monitoring system and method can be used to monitor reagent volume in assays for fluid replenishment control, monitor assays in real-time to obtain quality control information, monitor assays in real-time during development to detect saturation levels that can be used to shorten assay time, and provide assay results before the assay is complete, enabling reflex testing to begin automatically. The monitoring system can include a real time imaging system with a camera and lights to capture images of the assay. The captured images can then be used to monitor and control the quality of the staining process in an assay, provide early assay results, and/or to measure the on-site reagent volume within the assay.

Abstract: A housing part, in particular a lower housing part, of an energy storage housing, has two mutually spaced longitudinal elements which run in parallel with one another and extend in a longitudinal direction. The longitudinal elements are connected at end faces via transverse elements. A planar base element is fastened to the longitudinal elements. The longitudinal elements have contact regions which are oriented towards the base element, by which contact regions the base element is fastened to the longitudinal elements. Three weld seams extending in the longitudinal direction are formed in each of the contact regions.

Abstract: A voltage-controlled oscillator analog-to-digital converter (VCO-ADC) includes a first source follower coupled between a first input terminal and a first internal node; a first VCO having an input coupled to a second internal node; a first variable resistor coupled between the first internal node and the second internal node; and a digital signal processing component coupled between an output of the first VCO and a output terminal.

Abstract: Autonomous control of a subject vehicle including a longitudinal motion control system includes determining states of parameters associated with a trajectory for the subject vehicle and parameters associated with a control reference determined for the subject vehicle. A range control routine is executed to determine a first parameter associated with a range control command based upon the states of the plurality of parameters, and a speed control routine is executed to determine a second parameter associated with a speed control command based upon the states of the plurality of parameters. An arbitration routine is executed to evaluate the range control command and the speed control command, and operation of the subject vehicle is controlled to achieve a desired longitudinal state, wherein the desired longitudinal state is associated with a minimum of the range control command and the speed control command.

Abstract: A radar device for limiting radio-frequency power leakage is provided. The radar device includes a first component, and a second component. The first component has a first surface and a first waveguide that defines a first cavity. The second component has a second surface and a second waveguide that defines a second cavity. A first groove is provided that acts as a choke, and the first groove is defined in the first surface. The first component and the second component are assembled so that an air gap is maintained between the first waveguide and the second waveguide. The first waveguide and the second waveguide are configured to facilitate transmission of radio-frequency power. The first groove is configured to reduce leakage of radio-frequency power through the air gap. Additional chokes may also be included.

Abstract: A voltage-controlled oscillator analog-to-digital converter (VCO-ADC) includes a first source follower coupled between a first input terminal and a first internal node; a first VCO having an input coupled to a second internal node; a first variable resistor coupled between the first internal node and the second internal node; and a digital signal processing component coupled between an output of the first VCO and a output terminal.

Abstract: An analog-to-digital converter includes a voltage-controlled oscillator (VCO) having an input for receiving an analog input signal; a double binary counter having a first input coupled to a first output of the VCO, a second input coupled to a second output of the VCO; a first set of registers coupled to the first output of the double binary counter; a second set of registers coupled to the second output of the double binary counter; sense amplifiers coupled to the outputs of the VCO; and a correction component coupled to the first set of registers, the second set of registers, and the sense amplifiers, wherein the correction component generates a coarse count, a fine count, and combines the coarse count and the fine count to provide a digital output signal representative of the analog input signal.

Abstract: An automotive vehicle includes a vehicle-based charging unit including a receiving unit configured to receive power from a ground-based charging unit, the receiving unit including a multi-coil receiver, a first actuator operably coupled to the vehicle-based charging unit and configured to adjust a first position of the vehicle-based charging unit relative to the ground-based charging unit, and a controller configured to selectively actuate the first actuator.

Abstract: A vehicle including a Global Positioning System (GPS) sensor, an Inertial Measurement Unit (IMU), and an Advanced Driver Assistance System (ADAS) is described. Operating the vehicle includes determining, via the GPS sensor, first parameters associated with a velocity, a position, and a course, and determining, via the IMU, second parameters associated with acceleration and angular velocity. Roll and pitch parameters are determined based upon the first and second parameters. A first vehicle velocity vector is determined based upon the roll and pitch parameters, the first parameters, and the second parameters; and a second vehicle velocity vector is determined based upon the roll and pitch parameters, road surface friction coefficient, angular velocity, road wheel angles and the first vehicle velocity vector. A final vehicle velocity vector is determined based upon fusion of the first and second vehicle velocity vectors. The vehicle is controlled based upon the final vehicle velocity vector.

Abstract: A real time assay monitoring system and method can be used to monitor reagent volume in assays for fluid replenishment control, monitor assays in real-time to obtain quality control information, monitor assays in real-time during development to detect saturation levels that can be used to shorten assay time, and provide assay results before the assay is complete, enabling reflex testing to begin automatically. The monitoring system can include a real time imaging system with a camera and lights to capture images of the assay. The captured images can then be used to monitor and control the quality of the staining process in an assay, provide early assay results, and/or to measure the on-site reagent volume within the assay.

Abstract: Reverberation techniques for 3D audio are disclosed. In an example method, a three-dimensional (3D) reverberation is applied to a sound object placed at a sound object position in a sound room. The sound object originates from a sound object position. A sound object signal is received. A 3D spatial room response (SRR) signal is computed corresponding to the user-selected position. A time convolution operation is performed between an audio signal of the sound object signal and the computed SRR value to generate a reverberated signal.

Abstract: A real time assay monitoring system and method can be used to monitor reagent volume in assays for fluid replenishment control, monitor assays in real-time to obtain quality control information, monitor assays in real-time during development to detect saturation levels that can be used to shorten assay time, and provide assay results before the assay is complete, enabling reflex testing to begin automatically. The monitoring system can include a real time imaging system with a camera and lights to capture images of the assay. The captured images can then be used to monitor and control the quality of the staining process in an assay, provide early assay results, and/or to measure the on-site reagent volume within the assay.

Abstract: Provided herein are bispecific antigen-binding molecules that bind HER2 and methods of use thereof. The bispecific antigen-binding molecules comprise a first and a second antigen-binding domain, wherein the first and second antigen-binding domains bind to two different (preferably non-overlapping) epitopes of the extracellular domain of human HER2. The bispecific antigen-binding molecules cluster on the surface of HER2 IHC2+ and IHC3+ cells, and are internalized into the cellular lysosomes. Also included are antibody-drug conjugates (ADCs) comprising the antibodies or bispecific antigen-binding molecules provided herein linked to a cytotoxic agent, radionuclide, or other moiety, as well as methods of treating cancer in a subject by administering to the subject a bispecific antigen-binding molecule or an ADC thereof.

Abstract: A method for providing low speed lateral steering control for an autonomously driven or semi-autonomously driven vehicle includes obtaining a desired final vehicle position relative to a current vehicle position, and calculating, by one or more data processors, a target vehicle position based on the current vehicle position and the desired final vehicle position. The method further includes calculating, by the one or more data processors, a road wheel angle command value based on the target vehicle position; determining, by the one or more data processors, a control signal based on the calculated road wheel command value; and providing the control signal to a steering controller.

Abstract: A method and apparatus that determine parking feasibility are provided. The method includes determining a charging pad location based on information received from sensors or the charging pad, generating a path function corresponding to a path from a vehicle position to the charging pad location, determining whether a vehicle is within a parking maneuver feasibility region by comparing values of the generated path function, a minimum turning radius of the vehicle, and a maximum steering angle rate of the vehicle, and moving the vehicle to the charging pad location if the vehicle is in the parking maneuver feasibility region.

Abstract: A real time assay monitoring system and method can be used to monitor reagent volume in assays for fluid replenishment control, monitor assays in real-time to obtain quality control information, monitor assays in real-time during development to detect saturation levels that can be used to shorten assay time, and provide assay results before the assay is complete, enabling reflex testing to begin automatically. The monitoring system can include a real time imaging system with a camera and lights to capture images of the assay. The captured images can then be used to monitor and control the quality of the staining process in an assay, provide early assay results, and/or to measure the on-site reagent volume within the assay.

Abstract: A method and apparatus that control lateral movement of a vehicle are provided. The method includes receiving vehicle information and path information of the vehicle, determining a center of vehicle rotation from the vehicle information, minimizing a path tracking error based on the path information of the vehicle, determining a road wheel angle command or a steering torque command using non-linear optimization based on the minimized path tracking error, and controlling an actuator according to the road wheel angle command or steering torque command.

Abstract: A vehicle including a Global Positioning System (GPS) sensor, an Inertial Measurement Unit (IMU), and an Advanced Driver Assistance System (ADAS) is described. Operating the vehicle includes determining, via the GPS sensor, first parameters associated with a velocity, a position, and a course, and determining, via the IMU, second parameters associated with acceleration and angular velocity. Roll and pitch parameters are determined based upon the first and second parameters. A first vehicle velocity vector is determined based upon the roll and pitch parameters, the first parameters, and the second parameters; and a second vehicle velocity vector is determined based upon the roll and pitch parameters, road surface friction coefficient, angular velocity, road wheel angles and the first vehicle velocity vector. A final vehicle velocity vector is determined based upon fusion of the first and second vehicle velocity vectors. The vehicle is controlled based upon the final vehicle velocity vector.