Patents by Inventor Andre Richters

Andre Richters has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHIMERIC DEGRADERS OF CYCLIN-DEPENDENT KINASE 9 AND USES THEREOF
    Publication number: 20230158159
    Abstract: Provided herein are bifunctional compounds that bind cyclin-dependent kinase 9 (CDK9) and/or promote targeted ubiquitination for the degradation of CDK9. In particular, provided are compounds that can bind CDK9, a protein whose dysregulation is implicated in a variety of cancers, and can promote CDK9?s degradation by recruiting an E3 ubiquitin ligase (e.g., Cereblon, VHL). The E3 ubiquitin ligase can ubiquitinate CDK9, marking it for proteasomal degradation. Also provided are pharmaceutical compositions comprising the bifunctional compounds. Also provided are methods of treating cancer, and methods of promoting the degradation of CDK9 protein by E3 ubiquitin ligase activity in a subject or biological sample by administering a compound or composition described herein.
    Type: Application
    Filed: April 22, 2021
    Publication date: May 25, 2023
    Applicant: Massachusetts Institute of Technology
    Inventors: Angela N. Koehler, Andre Richters, Julie Urgiles, Florian Kabinger, Mohammed Abraham Toure
  • Small molecule modulators of the androgen receptor
    Patent number: 10961216
    Abstract: Provided herein are compounds useful for modulating the activity of an androgen receptor, or a variant thereof, and related compositions and methods. Compounds of the invention are useful for antagonizing the androgen receptor splice variant AR-v7, and for the treatment of castration-resistant prostate cancer.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: March 30, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: David Freeman, Nicholas B. Struntz, Shelby K. Doyle, Andre Richters, Angela N. Koehler
  • SMALL MOLECULE MODULATORS OF THE ANDROGEN RECEPTOR
    Publication number: 20190202800
    Abstract: Provided herein are compounds useful for modulating the activity of an androgen receptor, or a variant thereof, and related compositions and methods. Compounds of the invention are useful for antagonizing the androgen receptor splice variant AR-v7, and for the treatment of castration-resistant prostate cancer.
    Type: Application
    Filed: November 21, 2018
    Publication date: July 4, 2019
    Inventors: David Freeman, Nicholas B. Struntz, Shelby K. Doyle, Andre Richters, Angela N. Koehler