Abstract: Aspects of this invention, inter alia, relate to novel systems for targeting, editing or manipulating DNA in a cell, using novel synthetic RNA-guided nucleases (sRGNs). The sRGNs are derived from wildtype or parental small type II CRISPR Cas9 endonucleases.

Abstract: Disclosed herein is a projector for illuminating at least one object with at least one illumination pattern. The illumination pattern includes a plurality of illumination features, where the illumination pattern further includes at least one marker.

Abstract: Described herein is a detector for identifying at least one material property m. The detector includes at least one sensor element including a matrix of optical sensors, the optical sensors each having a light-sensitive area. The sensor element is configured for recording at least one reflection image of a light beam originating from at least one object. The detector includes at least one evaluation device configured for determining the material property m by evaluation of at least one beam profile of the reflection image and evaluation of a material feature ??2m.

Abstract: Described herein is a detector for identifying at least one material property m. The detector includes at least one sensor element including a matrix of optical sensors, the optical sensors each having a light-sensitive area. The sensor element is configured for recording at least one reflection image of a light beam originating from at least one object. The detector includes at least one evaluation device configured for determining the material property m by evaluation of at least one beam profile of the reflection image and evaluation of a material feature ?2m.

Abstract: A two-wheeler pneumatic tire, in which damage protection and puncture protection are improved while providing good rolling resistance and good tightness; the two-wheeler pneumatic tire in the bead regions has a protective layer which is disposed axially outside the carcass and which has strength members embedded in rubber material; wherein the tire carcass is formed from a first carcass ply and a second carcass ply disposed radially within in a vertex, and wherein the second carcass ply ends with a second carcass ply turn-up in a second carcass ply end in the bead region; the purpose of damage protection and puncture protection is achieved in that the first carcass ply is guided from the respective bead region in a first carcass ply turn-up over the respective tire sidewall to below the tread and at the latter ends in each case in a first carcass ply end; and that in each of the two axial halves the protective layer is guided from the bead region over the respective tire sidewall to below the tread.

Abstract: A two-wheeled vehicle pneumatic tire having a tread, a tire carcass, tire sidewalls, and two bead regions with a bead protective strip. The tire carcass is formed from a first carcass inlay and a second carcass inlay. The second carcass inlay is arranged radially inwardly of the first carcass inlay, and extends from a crown region (17) of the two-wheeled vehicle pneumatic tire and terminates at a second carcass inlay end under the bead protective strip. The two-wheeled vehicle pneumatic tire provides improved puncture protection whilst maintaining good rolling resistance. This is achieved in that the first carcass inlay is guided with a first carcass inlay turn-up over the particular tire sidewall as far as under the tread to a first carcass inlay end, and terminates there at the first carcass inlay end.

Abstract: Described herein is a detector for identifying at least one material property m. The detector includes at least one sensor element including a matrix of optical sensors, the optical sensors each having a light-sensitive area. The sensor element is configured for recording at least one reflection image of a light beam originating from at least one object. The detector includes at least one evaluation device configured for determining the material property by evaluation of at least one beam profile of the reflection image.

Abstract: An ultrasonic measuring device includes an ultrasonic transducer without voltage converter having two transducer terminals to which an alternately reversible control voltage can be applied for emitting an ultrasonic burst signal in a control phase and to which an evaluation voltage is applied in a reception phase. The ultrasonic transducer decays in a decay phase between the control phase and the reception phase. A control unit generates the control voltage. The control unit comprises a full bridge circuit with two half bridge circuits, each comprising two semiconductor driving switches, which are connected to the two terminals of the ultrasonic transducer. An evaluation unit is provided with two input terminals, each of which is connected to the terminals of the ultrasonic transducer via a connection line. Voltage limiting elements in the two terminal lines limit the voltage applied to the input terminals of the amplifier.

Abstract: Methods for producing at least a part of a sporting good, in particular a sports shoe, can include: (a) depositing a first material into a mold, and (b) vibrating the mold to modify the distribution of the first material in the mold.

Abstract: Disclosed is a driver stage for activating a first ultrasonic transducer and a method for the operation thereof. The driver stage comprises a first charge pump or power source and a first capacitor. The driver stage also comprises first means for charging the first capacitor with electrical energy from the charge pump and second means for connecting the first capacitor and ultrasonic transducer to different polarities. The first means do not charge the first capacitor with energy from the charge pump or power source when the first capacitor is connected to the ultrasonic transducer by the second means.

Abstract: A method of operating a gaseous fuel internal combustion engine comprises performing at least one measurement relating to the combustion of a mixture of gaseous fuel and air in a combustion chamber of an associated cylinder in a combustion cycle. At least one combustion parameter, for example, a start of combustion, is determined based on the at least one measurement. When the combustion parameter differs from a desired combustion parameter, an ignition device associated with the cylinder is controlled based on the comparison in order to control the combustion in the current combustion cycle.

Abstract: Described herein is a detector for identifying at least one material property m. The detector includes at least one sensor element including a matrix of optical sensors, the optical sensors each having a light-sensitive area. The sensor element is configured for recording at least one reflection image of a light beam originating from at least one object. The detector includes at least one evaluation device configured for determining the material property by evaluation of at least one beam profile of the reflection image.

Abstract: A self-testing measuring system includes at least three modes: an operating mode and at least two test modes. In a third test mode, a digital signal generating unit stimulates the digital input circuit directly by means of test signals. In a second test mode, the digital signal generating unit stimulates the analogue signal string and the digital input circuit by means of test signals. In a first test mode, the digital signal generating unit stimulates the analogue signal string, the measuring unit (typically an ultrasound transducer) and the digital input circuit by means of test signals, thereby allowing this signal string to be tested. In the operating mode, the digital signal generating unit stimulates the analogue signal string, the measuring unit (typically an ultrasound transducer) and the digital input circuit by means of output signals, thereby allowing the signal string to be monitored for parameter compliance.

Abstract: Disclosed is a driver stage for activating a first ultrasonic transducer and a method for the operation thereof. The driver stage comprises a first charge pump or power source and a first capacitor. The driver stage also comprises first means for charging the first capacitor with electrical energy from the charge pump and second means for connecting the first capacitor and ultrasonic transducer to different polarities. The first means do not charge the first capacitor with energy from the charge pump or power source when the first capacitor is connected to the ultrasonic transducer by the second means.

Abstract: An engine control system comprises a balancing arrangement together with a knock mitigation controller configured to implement a knock mitigation procedure wherein an offset input value (VI) is applied to the balancing algorithm. The offset input value (VI) may cause the balancing algorithm to adjust the control output (O1) for the respective one of the combustion chambers to progressively vary the fuel supply or ignition timing for the affected cylinder to mitigate the knock condition. Alternatively, the controller may generate an offset output value (VO) to more rapidly vary the fuel supply or ignition timing, with the offset input value (VI) being selected for example to compensate for the resulting change in the control input (I1) from the cylinder to the balancing algorithm, or to provide additional, more gradual adjustment to further mitigate the knock condition.

Abstract: A method of manufacturing compacts and an arrangement for manufacturing compacts, in which the disadvantages of the state of the art are overcome and an efficient method and at the same time a simple construction and a simple implementation are achieved. This involves a method for manufacturing compacts, wherein after feeding the feedstock, pre-pressing into a pre-agglomerate using at least one pre-pressing punch or at least one stuffing screw and subsequently main pressing of the pre-agglomerate into a compact in at least one pressing die using at least one main pressing punch and subsequently ejection of the compact from the at least one pressing die are performed, pre-pressing, main pressing and ejection being performed in a mutually parallel working direction. This also involves an arrangement for manufacturing compacts, wherein at least one pressing die is provided in die tool receptacle with a feed for feedstock.

Abstract: Disclosed is a method for detecting an erroneous bus node address allocation in data bus systems with auto addressing using an addressing current, such as LIN data bus systems with auto addressing. The method comprises performing auto addressing of the n bus nodes, causing an addressing current to be supplied by a bus node, sensing the data bus current by the bus nodes and determining a bus node-specific bus current measurement value, deciding, whether an addressing current flows through the respective bus node, and determining a bus node-specific addressing current presence value, transmitting the bus node-specific bus current measurement value and/or the bus node-specific addressing current presence value from the bus node to the bus master, forming a supply bus node-specific result vector from the received bus node-specific addressing current presence values, and comparing the supply bus node-specific result vector and a supply bus node-specific expectation vector.

Abstract: A self-testing measuring system includes at least three modes: an operating mode and at least two test modes. In a third test mode, a digital signal generating unit stimulates the digital input circuit directly by means of test signals. In a second test mode, the digital signal generating unit stimulates the analogue signal string and the digital input circuit by means of test signals. In a first test mode, the digital signal generating unit stimulates the analogue signal string, the measuring unit (typically an ultrasound transducer) and the digital input circuit by means of test signals, thereby allowing this signal string to be tested. In the operating mode, the digital signal generating unit stimulates the analogue signal string, the measuring unit (typically an ultrasound transducer) and the digital input circuit by means of output signals, thereby allowing the signal string to be monitored for parameter compliance.

Abstract: A method for starting a gaseous fuel internal combustion engine is disclosed. According to the disclosed method, the engine is rotated using a start device until a first speed threshold is reached. After reaching the first speed threshold, pilot fuel is supplied to a plurality of cylinders of the engine to combust the same. After performing an ignition health check, gaseous fuel is supplied to all or a relatively large number of cylinders to start accelerating the engine up to a second speed threshold.

Abstract: Disclosed is a method for detecting an erroneous bus node address allocation in data bus systems with auto addressing using an addressing current, such as LIN data bus systems with auto addressing. The method comprises performing auto addressing of the n bus nodes, causing an addressing current to be supplied by a bus node, sensing the data bus current by the bus nodes and determining a bus node-specific bus current measurement value, deciding, whether an addressing current flows through the respective bus node, and determining a bus node-specific addressing current presence value, transmitting the bus node-specific bus current measurement value and/or the bus node-specific addressing current presence value from the bus node to the bus master, forming a supply bus node-specific result vector from the received bus node-specific addressing current presence values, and comparing the supply bus node-specific result vector and a supply bus node-specific expectation vector.