Abstract: Described here are VHH antibody libraries with heavy chain variable domains framework scaffolds having complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members.

Abstract: Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

Abstract: Provided herein is an improved method of antibody affinity maturation that uses true natural CDRs from a population of naturally occurring antibodies targeting a single antigen or antigenic epitope such that the improved method produces functional antibodies having low-picomolar affinity antibodies. Also provided herein is an antibody library where the CDRs within a single antibody member of the library are a combination of CDR sequences of naturally occurring antibodies and one or more CDRs are derived from different naturally occurring antibodies targeting a single antigen or antigenic epitope.

Abstract: Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

Abstract: Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

Abstract: Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

Abstract: Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

Abstract: The disclosure relates to antibodies and antigen-binding fragments thereof that bind to Stem Cell Factor (SCF) with high affinity. The antibodies and antigen-binding fragments thereof specifically bind to SCF248 with high affinity. The disclosure further relates to methods of use of the antibodies including methods of treatment for inflammatory and/or fibrotic diseases and disorders.

Abstract: Described here are VHH antibody libraries with heavy chain variable domains framework scaffolds having complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members.

Abstract: Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

Abstract: A mooring line connector assembly (1) and a corresponding tensioner (28) are described. The mooring line connector assembly (1) comprises complementary male (2) and female (3) connectors, wherein the male connector (2) is rigid and the female connector (3) is connectable to the male connector (2) at a plurality of points along its length, so as to vary the tension applied to the mooring line. Locking balls engageable with grooves disposed along the length of the male connector (2) can allow the female connector to connect at different points along the male connector. A tensioner (28) allows the tension to be adjusted. The tensioner includes a first part (29) arranged to engage with the male connector (2) and a second part (29) arranged to engage with the female connector (3). The first part (29) reciprocates relative to the second part so as to move the male connector (2) relative to the female connector and thereby change the point at which the female connector is connected to the male connector.

Abstract: Provided herein is an improved method of antibody affinity maturation that uses true natural CDRs from a population of naturally occurring antibodies targeting a single antigen or antigenic epitope such that the improved method produces functional antibodies having low-picomolar affinity antibodies. Also provided herein is an antibody library where the CDRs within a single antibody member of the library are a combination of CDR sequences of naturally occurring antibodies and one or more CDRs are derived from different naturally occurring antibodies targeting a single antigen or antigenic epitope.

Abstract: Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

Abstract: Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

Abstract: Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

Abstract: A mooring line connector assembly (1) and a corresponding tensioner (28) are described. The mooring line connector assembly (1) comprises complementary male (2) and female (3) connectors, wherein the male connector (2) is rigid and the female connector (3) is connectable to the male connector (2) at a plurality of points along its length, so as to vary the tension applied to the mooring line. Locking balls engageable with grooves disposed along the length of the male connector (2) can allow the female connector to connect at different points along the male connector. A tensioner (28) allows the tension to be adjusted. The tensioner includes a first part (29) arranged to engage with the male connector (2) and a second part (29) arranged to engage with the female connector (3). The first part (29) reciprocates relative to the second part so as to move the male connector (2) relative to the female connector and thereby change the point at which the female connector is connected to the male connector.

Abstract: Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

Abstract: A mooring connector assembly (3) has a body (10) arranged to be pivotally mounted to a structure (1), such as a tethered buoy, to be moored for movement about a pivot axis. At least a part of the body extends below the pivot axis when so mounted and oriented for use. A line stopper (17) is mounted to the part of the body which extends below the pivot axis in use and is operative to retain a mooring line (2) relative to the body. The body is configured to receive a tensioner (20) for tensioning a mooring line (2) retained by the stopper such that the tensioner urges the line at a point which is below the pivot axis when the body is oriented for use. The body may be an elongate tube (10) pivotally connected to a structure to be moored (1) at one end and fitting with a chain stopper (17) at the opposite end. The tube is configured to receive a chain tensioner (20) between the chain stopper (17) and pivot axis.

Abstract: Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

Abstract: A mooring connector assembly (3) has a body (10) arranged to be pivotally mounted to a structure (1), such as a tethered buoy, to be moored for movement about a pivot axis. At least a part of the body extends below the pivot axis when so mounted and oriented for use. A line stopper (17) is mounted to the part of the body which extends below the pivot axis in use and is operative to retain a mooring line (2) relative to the body. The body is configured to receive a tensioner (20) for tensioning a mooring line (2) retained by the stopper such that the tensioner urges the line at a point which is below the pivot axis when the body is oriented for use. The body may be an elongate tube (10) pivotally connected to a structure to be moored (1) at one end and fitting with a chain stopper (17) at the opposite end. The tube is configured to receive a chain tensioner (20) between the chain stopper (17) and pivot axis.