Patents by Inventor Andrea Adamo
Andrea Adamo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200316602Abstract: Reservoir-based management of volumetric flow rates in fluidic systems is generally described. Inventive systems and methods for liquid-liquid separations and/or liquid-gas separations are also described.Type: ApplicationFiled: April 5, 2019Publication date: October 8, 2020Applicant: Zaiput Flow Technologies LLCInventors: Andrea Adamo, Robert Andrew Butters, Trevor Charles Murray
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Patent number: 10780410Abstract: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.Type: GrantFiled: August 14, 2015Date of Patent: September 22, 2020Assignee: Massachusetts Institute of TechnologyInventors: Klavs F. Jensen, Timothy F. Jamison, Allan S. Myerson, Jean-Christophe M. Monbaliu, Mohsen Behnam, Shin Yee Wong, Nopphon Weeranoppanant, Eve Marie Revalor, Torsten Stelzer, Jie Chen, Andrea Adamo, David R. Snead, Ping Zhang
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Publication number: 20200277566Abstract: A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.Type: ApplicationFiled: March 13, 2020Publication date: September 3, 2020Applicant: Massachusetts Institute of TechnologyInventors: Armon R. Sharei, Andrea Adamo, Robert S. Langer, Klavs F. Jensen
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Patent number: 10696944Abstract: A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.Type: GrantFiled: October 17, 2012Date of Patent: June 30, 2020Assignee: Massachusetts Institute of TechnologyInventors: Armon R. Sharei, Andrea Adamo, Robert S. Langer, Klavs F. Jensen
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Publication number: 20190126229Abstract: The instant disclosure is related to fluidic distributors, fluidic systems, and associated methods and articles. Certain embodiments are related to fluidic distributors that comprise bays including fluidic connections with relative positions that substantially correspond to each other. In some embodiments, a fluidic distributor may comprise bays with electrical interfaces with relative positions that substantially correspond to each other.Type: ApplicationFiled: May 2, 2017Publication date: May 2, 2019Applicant: Massachusetts Institute of TechnologyInventors: Andrea Adamo, Dale Arlington Thomas, III, Klavs F. Jensen, Timothy F. Jamison, Aaron A. Bedermann, Kosisochukwu C. Aroh
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Publication number: 20190093073Abstract: A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.Type: ApplicationFiled: September 25, 2018Publication date: March 28, 2019Applicant: Massachusetts Institute of TechnologyInventors: Armon R Sharei, Andrea Adamo, Robert S. Langer, Klavs F. Jensen
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Patent number: 9927038Abstract: Pressure control in fluidic systems is generally described. In some cases, a system comprises a fluid-permeable (e.g., liquid-permeable) medium and a pressure regulator. The medium and the pressure regulator can be positioned between a first fluidic channel and a second fluidic channel. The medium is arranged, in certain cases, such that fluid (e.g., liquid) can be transported from the first fluidic channel, through the medium, and into the second fluidic channel. In certain cases, when a first pressure within the first fluidic channel is below a sum of the permeability pressure differential of the medium with respect to the fluid and a second pressure within the second fluidic channel, the fluid is substantially prevented from being transported through an outlet of the first fluidic channel.Type: GrantFiled: August 9, 2013Date of Patent: March 27, 2018Assignee: Massachusetts Institute of TechnologyInventors: Andrea Adamo, Alexander P. Clayton, Patrick Louis Heider, Nopphon Weeranoppanant, Klavs F. Jensen
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Publication number: 20180066012Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.Type: ApplicationFiled: September 5, 2017Publication date: March 8, 2018Applicant: Massachusetts Institute of TechnologyInventors: Mark David Simon, Bradley L. Pentelute, Andrea Adamo, Patrick Louis Heider, Klavs F. Jensen
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Publication number: 20180057525Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.Type: ApplicationFiled: May 22, 2017Publication date: March 1, 2018Applicant: Massachusetts Institute of TechnologyInventors: Mark David Simon, Bradley L. Pentelute, Andrea Adamo, Patrick Louis Heider, Klavs F. Jensen
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Patent number: 9868759Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.Type: GrantFiled: September 14, 2015Date of Patent: January 16, 2018Assignee: Massachusetts Institute of TechnologyInventors: Mark David Simon, Bradley L. Pentelute, Andrea Adamo, Patrick Louis Heider, Klavs F. Jensen
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Patent number: 9695214Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.Type: GrantFiled: February 24, 2014Date of Patent: July 4, 2017Assignee: Massachusetts Institute of TechnologyInventors: Mark David Simon, Bradley L. Pentelute, Andrea Adamo, Patrick Louis Heider, Klavs F. Jensen
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Publication number: 20170081359Abstract: Methods and system for solid phase peptide synthesis are provided. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. New amino acid residues are added via a coupling reaction between an activated amino acid and an amino acid residue of the immobilized peptide. Amino acids may be activated using, e.g., a base and an activating agent. Certain inventive concepts, described herein, relate to methods and systems for the activation of amino acids. These systems and methods may allow for fewer side reactions and a higher yield compared to conventional activation techniques as well as the customization of the coupling reaction on a residue-by-residue basis without the need for costly and/or complex processes.Type: ApplicationFiled: September 16, 2016Publication date: March 23, 2017Applicant: Massachusetts Institute of TechnologyInventors: Dale Arlington Thomas, III, Alexander James Mijalis, Bradley L. Pentelute, Mark David Simon, Andrea Adamo, Patrick Louis Heider, Klavs F. Jensen
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Publication number: 20160102118Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.Type: ApplicationFiled: September 14, 2015Publication date: April 14, 2016Applicant: Massachusetts Institute of TechnologyInventors: Mark David Simon, Bradley L. Pentelute, Andrea Adamo, Patrick Louis Heider, Klavs F. Jensen
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Publication number: 20160031931Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.Type: ApplicationFiled: February 24, 2014Publication date: February 4, 2016Applicant: Massachusetts Institute of TechnologyInventors: Mark David Simon, Bradley L. Pentelute, Andrea Adamo, Patrick Louis Heider, Klavs F. Jensen
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Patent number: 9169287Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.Type: GrantFiled: March 15, 2013Date of Patent: October 27, 2015Assignee: Massachusetts Institute of TechnologyInventors: Mark David Simon, Bradley L. Pentelute, Andrea Adamo, Patrick Louis Heider, Klavs F. Jensen
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Publication number: 20150285387Abstract: Pressure control in fluidic systems is generally described. New trends in chemical synthesis involve the use of continuous reaction schemes, for example, in microfluidic and/or millifluidic devices. In many of these processes, it is often helpful to maintain controlled separation between two liquid phases and/or between a liquid phase and a gas phase. For example, in many processes, liquid-liquid and/or a gas-liquid separations are performed (e.g.Type: ApplicationFiled: August 9, 2013Publication date: October 8, 2015Applicant: Massachusetts Institute of TechnologyInventors: Andrea Adamo, Alexander P. Clayton, Patrick Louis Heider, Nopphon Weeranoppanant, Klavs F. Jensen
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Publication number: 20140287509Abstract: A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.Type: ApplicationFiled: October 17, 2012Publication date: September 25, 2014Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Armon R. Sharei, Andrea Adamo, Robert S. Langer, Klavs F. Jensen
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Publication number: 20140275481Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Inventors: Mark David Simon, Bradley L. Pentelute, Andrea Adamo, Patrick Louis Heider, Klavs F. Jensen
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Publication number: 20100190242Abstract: We describe a system for the division or partition of a volume of fluid into droplets of assigned size and subsequent recollection of the drops.Type: ApplicationFiled: January 22, 2010Publication date: July 29, 2010Inventors: Andrea Adamo, Jennifer Lynn Baltz, Luigi Adamo
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Publication number: 20090280518Abstract: A system for measuring a mechanical property of a cell is provided. The system includes a body having a channel therethrough with a first end and a second end, the channel including at least one cell deforming feature configured to deform a cell passing through the channel. A first sensor system is positioned on the first end side of the cell deforming feature and a second sensor system is positioned on the second end side of the cell deforming feature, and the first and second sensor systems are configured to detect information about a cell as the cell travels across the cell deforming feature. A controller communicating with the first and second sensor systems is adapted to receive data from the first and second sensor systems and calculate a mechanical property of the cell.Type: ApplicationFiled: May 7, 2009Publication date: November 12, 2009Applicant: Massachusetts Institute of TechnologyInventors: Andrea Adamo, Rangel P. Dokov, Klavs F. Jensen