Abstract: A compound of formula I having the structure: or a pharmaceutically acceptable salt thereof, wherein A1 and A2 are independently O or S; X is selected from CH2, CD2, NR3, O, and S, where R3 is selected from hydrogen, C1-C4 linear or branched chain alkyl, halo(C1-C4)linear or branched chain alkyl, and hydroxyl(C1-C4)linear or branched chain alkyl; Y and Z are selected from C and N, where when Y is C, then Z is N, and when Y is N, then Z is C; R1 and R2 are independently selected from hydrogen, deuterium, C1-C4 linear or branched chain alkyl, etc.; or a C1-C2 alkyl substituted with a C3-C5 cycloalkyl ring; or taken together to form a C3-C6 cycloalkyl ring; or where X is CH2 or CD2, then R1 and R2 are independently selected from hydrogen, deuterium, halogen, hydroxyl, C1-C4 linear or branched chain alkyl, etc.; R4 is selected from hydrogen, deuterium, cyano, halogen, (C1-C3) alkoxy, etc.; R5 is selected from hydrogen, deuterium, halogen, C1-C3 alkoxy, amino, (C1-C4 linear or branched chain alkyl)amino, etc.

Abstract: An optical arrangement of data smart glasses includes a first laser device configured to emit a projection light beam, a second laser device configured to emit a measuring light beam, a first scanner, a second scanner, and a beam combiner configured to bundle the projection light beam and the measuring light beam into a common light beam, wherein the first scanner is configured to deflect the projection light beam emitted by the first laser device in a first axis, and wherein the second scanner is configured to deflect the common light beam focused by the beam combiner in a second axis.

Abstract: The invention relates to a collapsible ring made of several side walls (15, 16) for a transportation container (11), which is positioned to stand on a palette base (12) of a transportation palette (13) and surrounds an interior (19) delimited by the side walls (15, 16), and at least one intermediate base (31) that can be arranged in the ring (14) in a usage position (32) and having at least one releasable connection (34) formed between the side wall (15, 16) and the intermediate base (31), said connection being formed by at least one holding element (36), wherein adjacent and/or opposing side walls (15, 16) are held by the releasable connection (34) at a distance to the intermediate base (31), and the intermediate base (31) is simultaneously positioned by the releasable connection (34) to the usage position (32) in relation to the adjacent side wall.

Abstract: The present invention relates to novel aminoglycoside compounds having antimicrobial properties and being suitable, for example, as therapeutic agents for use in the treatment of mammalian disease and in particular to novel therapeutic agents suitable for use in the treatment of microbial infection in mammals. The present invention further relates to the use of pharmaceutical compositions comprising said agents in the treatment of medical conditions in mammals, in particular in the treatment of microbial infection. The agents and pharmaceutical compositions of the invention are of particular relevance in the treatment of diseases associated with antibiotic-resistant microbes. The invention further relates to compounds for use in the treatment of diseases whose treatment is made otherwise difficult due to antibiotic-class-related bacterial resistance and provides novel therapeutic agents suitable for use in the treatment of multidrug-resistant (MDR) infections.

Abstract: An apparatus for producing metal organic frameworks, comprising: a tubular flow reactor comprising a tubular body into which, in use, precursor compounds which form the metal organic framework are fed and flow, said tubular body including at least one annular loop.

Abstract: The invention relates to a collapsible ring made of several side walls (15, 16) for a transportation container (11), which is positioned to stand on a palette base (12) of a transportation palette (13) and surrounds an interior (19) delimited by the side walls (15, 16), and at least one intermediate base (31) that can be arranged in the ring (14) in a usage position (32) and having at least one releasable connection (34) formed between the side wall (15, 16) and the intermediate base (31), said connection being formed by at least one holding element (36), wherein adjacent and/or opposing side walls (15, 16) are held by the releasable connection (34) at a distance to the intermediate base (31), and the intermediate base (31) is simultaneously positioned by the releasable connection (34) to the usage position (32) in relation to the adjacent side wall.

Abstract: An apparatus for producing metal organic frameworks, comprising: a tubular flow reactor comprising a tubular body into which, in use, precursor compounds which form the metal organic framework are fed and flow, said tubular body including at least one annular loop.

Abstract: An apparatus for producing metal organic frameworks, comprising: a tubular flow reactor comprising a tubular body into which, in use, precursor compounds which form the metal organic framework are fed and flow, said tubular body including at least one annular loop.

Abstract: An apparatus for producing metal organic frameworks, comprising: a tubular flow reactor comprising a tubular body into which, in use, precursor compounds which form the metal organic framework are fed and flow, said tubular body including at least one annular loop.

Abstract: An apparatus for producing metal organic frameworks, comprising: a tubular flow reactor comprising a tubular body into which, in use, precursor compounds which form the metal organic framework are fed and flow, said tubular body including at least one annular loop.

Abstract: A train loading system for loading material onto cars of a train is disclosed. The system comprises a material bin arranged to receive material to be loaded onto the train, a closure device arranged to facilitate control by an operator of the amount of material loaded into each car from the material bin, and a car mass estimator arranged to estimate the mass of material loaded into each car. The system also comprises a display arranged to communicate to the operator the estimated mass of material loaded into each car. A corresponding method is also disclosed.

Abstract: An apparatus for producing metal organic frameworks, comprising: a tubular flow reactor comprising a tubular body into which, in use, precursor compounds which form the metal organic framework are fed and flow, said tubular body including at least one annular loop.

Abstract: The invention relates to drug development and synthetic chemistry, in particular to the manufacture of biologically active compounds based on naturally occurring molecules. It also relates to novel biologically active compounds, for example aminoglycoside antibiotics, in a substantially pure regioisomeric form. More particularly, the present invention relates to methods for the chemo- or regioselective derivatization of a target compound with multiple reactive groups, some of which may be derivatezed, and other which will not be derivatized.

Abstract: The invention relates to the field of carbohydrate chemistry. Provided is a process for the regioselective oxidation of a single secondary hydroxy function of a carbohydrate substrate comprising two or more secondary hydroxy functions, comprising contacting the carbohydrate substrate in a solvent in the presence of a transition metal catalyst complex with an oxidizing agent to yield a mono-oxidized carbohydrate.

Abstract: An apparatus for producing metal organic frameworks, comprising: a tubular flow reactor comprising a tubular body into which, in use, precursor compounds which form the metal organic framework are fed and flow, said tubular body including at least one annular loop.

Abstract: An apparatus for producing metal organic frameworks, comprising: a tubular flow reactor comprising a tubular body into which, in use, precursor compounds which form the metal organic framework are fed and flow, said tubular body including at least one annular loop.

Abstract: An apparatus for producing metal organic frameworks, comprising: a tubular flow reactor comprising a tubular body into which, in use, precursor compounds which form the metal organic framework are fed and flow, said tubular body including at least one annular loop.

Abstract: An apparatus for producing metal organic frameworks, comprising: a tubular flow reactor comprising a tubular body into which, in use, precursor compounds which form the metal organic framework are fed and flow, said tubular body including at least one annular loop.

Abstract: A train loading system for loading material onto cars of a train is disclosed. The system comprises a material bin arranged to receive material to be loaded onto the train, a closure device arranged to facilitate control by an operator of the amount of material loaded into each car from the material bin, and a car mass estimator arranged to estimate the mass of material loaded into each car. The system also comprises a display arranged to communicate to the operator the estimated mass of material loaded into each car. A corresponding method is also disclosed.

Abstract: This invention comprises filled silicone compositions initially having a slump of at least 2.5 millimeters when tested described in ASTM D2202-00(2010) except temperature shall be 25 degrees Celsius and time shall be 5 minutes, and a method of preparing and uses of the composition.