Patents by Inventor Andrea Aramini

Andrea Aramini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C5AR INHIBITORS FOR USE IN THE TREATMENT OF CHEMOTHERAPY-INDUCED IATROGENIC PAIN
    Publication number: 20240398731
    Abstract: The present invention relates to C5aR inhibitor compounds, preferably C5aR noncompetitive allosteric inhibitors, useful in the treatment and/or prevention of chemotherapy-induced iatrogenic pain (CIIP).
    Type: Application
    Filed: August 9, 2024
    Publication date: December 5, 2024
    Inventors: Laura BRANDOLINI, Thiago Mattar CUNHA, Marcello ALLEGRETTI, Andrea ARAMINI, Gianluca BIANCHINI
  • IL-8 inihibitors for use in the treatment of some urological disorders
    Patent number: 12150933
    Abstract: The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1/CXCR2 receptor inhibitors, useful in the treatment and/or prevention of interstitial cystitis/painful bladder syndrome (IC/PBS) and/or over active bladder (OAB), also including IC/PBS and/or OAB induced by anticancer therapy. Methods of treatment and/or prevention, combinations and kits comprising said IL-8 inhibitors are also covered therein.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: November 26, 2024
    Assignee: DOMPÈ FARMACEUTICI S.P.A.
    Inventors: Marcello Allegretti, Andrea Aramini, Maria Candida Cesta, Gianluca Bianchini, Laura Brandolini, Patrizia Angelico
  • C5aR inhibitors for use in the treatment of chemotherapy-induced iatrogenic pain
    Patent number: 12102607
    Abstract: The present invention relates to C5aR inhibitor compounds, preferably C5aR noncompetitive allosteric inhibitors, useful in the treatment and/or prevention of chemotherapy-induced iatrogenic pain (CIIP).
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: October 1, 2024
    Assignee: Dompe' Farmaceutici S.P.A.
    Inventors: Laura Brandolini, Thiago Mattar Cunha, Marcello Allegretti, Andrea Aramini, Gianluca Bianchini
  • C5AR1 INHIBITORS FOR TREATING HYPERSENSITIVITY REACTIONS TO TAXANES
    Publication number: 20240180888
    Abstract: The present invention relates to the use of a C5aR1 inhibitor for the prevention or treatment of a hypersensitivity reaction (HSR) to a taxane in an individual.
    Type: Application
    Filed: March 17, 2022
    Publication date: June 6, 2024
    Inventors: Marcello ALLEGRETTI, Andrea ARAMINI, Piergiorgio AMENDOLA, Laura BRANDOLINI, Maria Candida CESTA, Anna SIRICO
  • NGF ISOFORM FOR USE IN THE TREATMENT OF OCULAR PATHOLOGIES
    Publication number: 20240091311
    Abstract: The present invention relates to the field of treatment of ocular pathologies by administration of a NGF, which comprises more than 50% by weight of the NGF isoform of SEQ ID NO: 1. Said NGF is particularly useful in the treatment of ocular pathologies where the proliferation and survival effect of NGF is desired and where the proapoptotic effect of p75NTR is detrimental.
    Type: Application
    Filed: February 4, 2022
    Publication date: March 21, 2024
    Inventors: Andrea ARAMINI, Pier Giorgio AMENDOLA, Anna SIRICO, Gaetano D'ANNIBALLE, Franca CATTANI, Marcello ALLEGRETTI, Flavio MANTELLI
  • CO-CRYSTAL OF KETOPROFEN, LYSINE AND GABAPENTIN, PHARMACEUTICAL COMPOSITIONS AND THEIR MEDICAL USE
    Publication number: 20230357121
    Abstract: The present invention relates to a new co-crystal of Ketoprofen, Lysine and Gabapentin, to pharmaceutical compositions and to their use in the prevention, reduction or treatment of pain and/or inflammation.
    Type: Application
    Filed: May 4, 2021
    Publication date: November 9, 2023
    Inventors: Andrea ARAMINI, Marcello ALLEGRETTI, Gianluca BIANCHINI, Samuele LILLINI, Mara TOMASSETTI
  • CO-CRYSTAL OF GABAPENTIN, KETOPROFEN AND LYSINE, PHARMACEUTICAL COMPOSITIONS AND THEIR MEDICAL USE
    Publication number: 20230181507
    Abstract: The present invention relates to a new co-crystal of Gabapentin, Ketoprofen and Lysine, to pharmaceutical compositions and to their use in the prevention, reduction or treatment of pain and/or inflammation.
    Type: Application
    Filed: April 21, 2021
    Publication date: June 15, 2023
    Inventors: Andrea ARAMINI, Marcello ALLEGRETTI, Gianluca BIANCHINI, Samuele LILLINI, Mara TOMASSETTI
  • SYNERGISTIC ADMIXTURES OF GABAPENTIN AND KETOPROFEN, PHARMACEUTICAL COMPOSITIONS AND THEIR MEDICAL USE
    Publication number: 20230165820
    Abstract: The present invention relates to a synergistic admixture of Gabapentin and Ketoprofen, preferably Ketoprofen Lysine, to a pharmaceutical composition comprising said admixtures and to the use of said admixtures or pharmaceutical compositions in the treatment of acute or chronic pain, in particular in the treatment of neuropathic or inflammatory pain.
    Type: Application
    Filed: April 21, 2021
    Publication date: June 1, 2023
    Inventors: Andrea ARAMINI, Marcello ALLEGRETTI, Gianluca BIANCHINI, Samuele LILLINI, Mara TOMASSETTI, Laura BRANDOLINI
  • CO-CRYSTAL OF KETOPROFEN AND ITS PREPARATION, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND USES THEREOF
    Publication number: 20230002302
    Abstract: The present invention refers to a eco-crystal of Ketoprofen Lysine named Form 4, a pharmaceutical composition comprising said co-crystal, a process for its preparation and to its use in the treatment of pain and Inflammatory diseases.
    Type: Application
    Filed: December 21, 2020
    Publication date: January 5, 2023
    Inventors: Andrea ARAMINI, GianÍuca BIANCHINI, Samuele LILLINI
  • NEW COMPOSITION CONTAINING BRANCHED-CHAIN AMINO ACIDS
    Publication number: 20220296670
    Abstract: The present invention relates to compositions comprising branched-chain amino acids (BCAA) and the dipeptide L-Alanyl-L-alanine and their use for improving the performance and recovery during physical activity and for the prevention and/or treatment of muscle wasting associated to pathological or age-related conditions.
    Type: Application
    Filed: June 29, 2020
    Publication date: September 22, 2022
    Inventors: Marcello ALLEGRETTI, Andrea ARAMINI, Gianluca BIANCHINI
  • COMPOSITION FOR THE TREATMENT OF MUSCLE WASTING
    Publication number: 20220296551
    Abstract: The present invention relates to compositions comprising branched-chain amino acids (BCAA) and the amino acid L-Alanine and their use in the prevention and/or treatment of muscle wasting associated to pathological or age-related conditions.
    Type: Application
    Filed: June 29, 2020
    Publication date: September 22, 2022
    Inventors: Marcello ALLEGRETTI, Andrea ARAMINI, Gianluca BIANCHINI
  • IL-17A BINDING PEPTIDES AND MEDICAL USES THEREOF
    Publication number: 20220112244
    Abstract: The invention relates to IL-17A binding peptides, inhibitors of the interaction of IL-17A with the receptor IL-17RA, and to bioconjugates, dimers, pharmaceutical compositions and medical use thereof.
    Type: Application
    Filed: December 17, 2021
    Publication date: April 14, 2022
    Inventors: Marcello Allegretti, Andrea Aramini, Andrea Beccari, Marica Gemei, Flavio Mantelli
  • CO-CRYSTAL OF KETOPROFEN, COMPOSITIONS COMPRISING THE SAME, PROCESS OF PRODUCING THE SAME, AND USES THEREOF
    Publication number: 20220071936
    Abstract: The present invention refers to a co-crystal of Ketoprofen Lysine named Form 1, a pharmaceutical composition comprising said co-crystal, a process for its production and to its use in the treatment of pain and inflammatory diseases.
    Type: Application
    Filed: December 20, 2019
    Publication date: March 10, 2022
    Inventors: Andrea ARAMINI, Gianluca BIANCHINI, Samuele LILLINI
  • IL-17A binding peptides and medical uses thereof
    Patent number: 11236129
    Abstract: The invention relates to IL-17A binding peptides, inhibitors of the interaction of IL-17A with the receptor IL-17RA, and to bioconjugates, dimers, pharmaceutical compositions and medical use thereof.
    Type: Grant
    Filed: January 26, 2021
    Date of Patent: February 1, 2022
    Assignee: Dompe' Farmaceutici S.P.A.
    Inventors: Marcello Allegretti, Andrea Aramini, Andrea Beccari, Marica Gemei, Flavio Mantelli
  • IL-17A BINDING PEPTIDES AND MEDICAL USES THEREOF
    Publication number: 20210300969
    Abstract: The invention relates to IL-17A binding peptides, inhibitors of the interaction of IL-17A with the receptor IL-17RA, and to bioconjugates, dimers, pharmaceutical compositions and medical use thereof.
    Type: Application
    Filed: January 26, 2021
    Publication date: September 30, 2021
    Inventors: Marcello Allegretti, Andrea Aramini, Andrea Beccari, Marica Gemei, Flavio Mantelli
  • 2-aryl-4-hydroxy-1,3-thiazole derivatives useful as TRPM8-inhibitors in treatment of neuralgia, pain, COPD and asthma
    Patent number: 11046662
    Abstract: The invention relates to compounds acting as selective antagonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), and having formula (I). The compounds of the invention are useful in the treatment of diseases associated with activity of TRPM8 such as pain, inflammation, ischaemia, neurodegeneration, stroke, psychiatric disorders, itch, irritable bowel diseases, cold induced and/or exacerbated respiratory disorders and urological disorders.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: June 29, 2021
    Assignee: DOMPÉ FARMACEUTICI S.P.A.
    Inventors: Andrea Aramini, Gianluca Bianchini, Laura Brandolini, Andrea Beccari, Samuele Lillini, Giuseppe Nano
  • C5AR INHIBITORS FOR USE IN THE TREATMENT OF CHEMOTHERAPY-INDUCED IATROGENIC PAIN
    Publication number: 20200397725
    Abstract: The present invention relates to C5aR inhibitor compounds, preferably C5aR noncompetitive allosteric inhibitors, useful in the treatment and/or prevention of chemotherapy-induced iatrogenic pain (CIIP).
    Type: Application
    Filed: December 11, 2018
    Publication date: December 24, 2020
    Inventors: Laura Brandolini, Thiago Mattar Cunha, Marcello Allegretti, Andrea Aramini, Gianluca Bianchini
  • NEUROTROPHINS FOR USE IN THE TREATMENT OF HEARING LOSS
    Publication number: 20200155647
    Abstract: The present invention relates to the use of neurotrophins in the treatment of hearing disorders related to hearing loss using the transtympanic route of administration, in particular in the treatment of sudden deafness, blast-induced hearing loss, ototoxicity, ARHL (age related hearing loss) and noise damage. The invention further relates to the use of compositions containing neurotrophins, in particular NGF, in the treatment of hearing disorders.
    Type: Application
    Filed: May 22, 2018
    Publication date: May 21, 2020
    Inventors: Maria DE PIZZOL, Andrea ARAMINI, Anna SIRICO, Mara ZIPPOLI, Giuseppina ACERRA, Simone Luca MATTIOLI
  • Sulfonamides as GPR40- and GPR120-agonists
    Patent number: 10508090
    Abstract: The invention relates to compounds acting as agonists of G-protein coupled receptor 120 (GPR120) and/or 40 (GPR40), and having formula (I): Said compounds are useful in the treatment of diseases or disorders modulated by GPR120 and/or GPR40 such as diabetes (particularly type 2 diabetes), impaired oral glucose tolerance, insulin resistance, obesity, obesity related disorders, metabolic syndrome, dyslipidemia, elevated LDL, elevated triglycerides, obesity induced inflammation, osteoporosis and obesity related cardiovascular disorders.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: December 17, 2019
    Assignee: DOMPÉ FARMACEUTICI S.P.A.
    Inventors: Maria De Pizzol, Anna Sirico, Mara Zippoli, Gianluca Bianchini, Andrea Beccari, Andrea Aramini, Chiara Rossana Maria Liberati
  • IL-8 INHIBITORS FOR USE IN THE TREATMENT OF SOME UROLOGICAL DISORDERS
    Publication number: 20190336484
    Abstract: The present invention relates to IL-8 inhibitor compounds for use in the treatment of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and benign prostatic hyperplasia.
    Type: Application
    Filed: January 2, 2018
    Publication date: November 7, 2019
    Inventors: Maria Candida CESTA, Marcello ALLEGRETTI, Andrea ARAMINI, Gianluca BIANCHINI, Laura BRANDOLINI