Abstract: Disclosed herein are methods of identifying a compound for treating or preventing an infection with an infectious microbe, such as a coronavirus, in a subject in need thereof. Also disclosed herein are compounds and compositions identified by said methods, and methods of use thereof.

Abstract: A sandbox for rail vehicles, of a type comprising a sand container, on the bottom of which there is a hollow body which presents one or several openings through which sand flows out towards an ejector assembly beneath by passing through an outlet hole controlled by an axially sliding vertical shutter located inside the hollow body is provided. The shutter translates between a lower position in which the output hole is closed and an upper, maximum opening position, whereby the shutter features a cylindrical shape and its lower end functionally cooperates with a ring shaped, sealing coaxial seat, corresponding to the outlet hole of the container.

Abstract: The invention relates a sandbox for rail vehicles, of a type comprising a sand container, on the bottom of which there is a hollow body which presents one or several openings through which sand flows out towards an ejector assembly beneath by passing through an outler hole controlled by an axially sliding vertical shutter located inside said hollow body and means handling and controlling said shutter which cause its translation between a lower position in which said output hole is closed and an upper, maximum opening position, whereby said shutter features a cylindrical shape and its lower end functionally cooperates with a ring shaped, sealing coaxial seat, corresponding to said outlet hole of said container.