Patents by Inventor Andrea Brambilla
Andrea Brambilla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11808565Abstract: A method is provided for characterizing a sample, by estimating a plurality of characteristic thicknesses, each being associated with a calibration material. The method includes acquiring an energy spectrum transmitted through the sample, located in an X and/or gamma spectral band; for each spectrum of a plurality of calibration spectra, calculating a likelihood from said calibration spectrum, and from the spectrum transmitted through the sample, each calibration spectrum corresponding to the energy spectrum transmitted through a stack of gauge blocks, each formed of a known thickness of a calibration material; and estimating the characteristic thicknesses associated with the sample according to the criterion of maximum likelihood.Type: GrantFiled: February 25, 2021Date of Patent: November 7, 2023Assignee: Commissariat a L'Energie Atomique et aux Energies AlternativesInventors: Andrea Brambilla, Alexia Gorecki, Alexandra Potop
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Patent number: 11639490Abstract: The invention discloses a device and method for producing and purifying exosomes from progenitor cells using a closed and sterile circuit having a pumping means and a plurality of serially connected processing stations.Type: GrantFiled: December 28, 2017Date of Patent: May 2, 2023Assignee: Foundation for Cardiological Research and Education (FCRE)Inventors: Gabriella Andriolo, Elena Provasi, Andrea Brambilla, Viviana Giovanna Lo Cicero, Sabrina Soncin, Lucio Barile, Lucia Turchetto, Marina Radrizzani, Giuseppe Vassalli
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Publication number: 20210199429Abstract: The invention relates to a method for characterizing a sample, by estimating a plurality of characteristic thicknesses, each being associated with a calibration material, comprising the following steps: acquiring an energy spectrum (Sech) transmitted through this sample, located in an X and/or gamma spectral band, naled spectrum transmitted through the sample; for each spectrum of a plurality of calibration spectra (Sbase(Lk; Ll)), calculating a likelihood from said calibration spectrum (Sbase(Lk; Ll)), and from the spectrum transmitted through the sample (Sech), each calibration spectrum (Sbase(Lk; Ll)) corresponding to the energy spectrum transmitted through a stack of gauge blocks, each formed of a known thickness of a calibration material; estimating the characteristic thicknesses (L1, L2) associated with the sample according to the criterion of maximum likelihood.Type: ApplicationFiled: February 25, 2021Publication date: July 1, 2021Applicant: Commissariat a L'Energie Atomique et aux Energies AlternativesInventors: Andrea BRAMBILLA, Alexia GORECKI, Alexandra POTOP
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Patent number: 10983070Abstract: The invention is a method for characterizing an object (20), comprising the following steps: a) placing the object between a radiation source (10) and a radiation detector (30); b) irradiating the object with the radiation source and detecting radiation transmitted by the object (14) using the radiation detector, the radiation detector defining a plurality of pixels; c) for each pixel (30i), forming an energy spectrum (Si) of the detected radiation, each spectrum comprising at least two distinct energy bands; d) from each spectrum formed in c), estimating, in each pixel, at least two equivalent thicknesses ({circumflex over (L)}i,1 . . . {circumflex over (L)}i,M,{circumflex over (L)}?i,1 . . . {circumflex over (L)}?i,M) respectively associated with at least two basic materials (mat1 . . . matM,mat?1 . . .Type: GrantFiled: June 21, 2019Date of Patent: April 20, 2021Assignee: Commissariat a l'energie atomique et aux energies alternativesInventors: Caroline Paulus, Andrea Brambilla, Veronique Rebuffel
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Patent number: 10969220Abstract: A method for characterizing a sample, by estimating a plurality of characteristic thicknesses, each being associated with a calibration material, including acquiring an energy spectrum (Sech) transmitted through this sample, located in an X and/or gamma spectral band; for each spectrum of a plurality of calibration spectra (sbase(Lk; Lt)) calculating a likelihood from said calibration spectrum (Sbase(Lk; Lt)), and from the spectrum transmitted through the sample (Sech), each calibration spectrum (Sbase(Lk; Lt)) corresponding to the energy spectrum transmitted through a stack of gauge blocks, each formed of a known thickness of a calibration material; estimating the characteristic thicknesses (L1, L2) associated with the sample according to the criterion of maximum likelihood.Type: GrantFiled: June 14, 2016Date of Patent: April 6, 2021Assignee: Commissariat a L'Energie Atomique et aux Energies AlternativesInventors: Andrea Brambilla, Alexia Gorecki, Alexandra Potop
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Publication number: 20200283715Abstract: The invention discloses a device and method for producing and purifying exosomes from progenitor cells using a closed and sterile circuit having a pumping means and a plurality of serially connected processing stations.Type: ApplicationFiled: December 28, 2017Publication date: September 10, 2020Applicant: LUGANO TECHNOLOGY TRANSFER (LTT) SAInventors: Gabriella ANDRIOLO, Elena PROVASI, Andrea BRAMBILLA, Viviana Giovanna LO CICERO, Sabrina SONCIN, Lucio BARILE, Lucia TURCHETTO, Marina RADRIZZANI, Giuseppe VASSALLI
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Patent number: 10641909Abstract: The invention is a method for processing a pulse generated by a detector of ionizing radiation, the detector being configured to interact with ionizing radiation in order to generate said pulse, the amplitude of which depends on an energy liberated by the ionizing radiation during its interaction in the detector, the method including the following steps: a) exposing the detector to a source of ionizing radiation so as to obtain, at a measurement time, a pulse called the measurement pulse; b) shaping the measurement pulse, using a first shaping time, and determining a first amplitude of the measurement pulse thus shaped; and c) correcting the first amplitude measured in step b), by taking into account a correction factor; the correction factor being determined by taking into account pulses, called pulses of interest, formed by the detector during an exposure to the source or to a calibration source, during a time range of interest.Type: GrantFiled: July 17, 2018Date of Patent: May 5, 2020Assignee: Commissariat a l'energie atomique et aux energies alternativesInventors: Andrea Brambilla, Cinzia De Cesare
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Publication number: 20190391090Abstract: The invention is a method for characterizing an object (20), comprising the following steps: a) placing the object between a radiation source (10) and a radiation detector (30); b) irradiating the object with the radiation source and detecting radiation transmitted by the object (14) using the radiation detector, the radiation detector defining a plurality of pixels; c) for each pixel (30i), forming an energy spectrum (Si) of the detected radiation, each spectrum comprising at least two distinct energy bands; d) from each spectrum formed in c), estimating, in each pixel, at least two equivalent thicknesses ({circumflex over (L)}i,1 . . . {circumflex over (L)}i,M,{circumflex over (L)}?i,1 . . . {circumflex over (L)}?i,M) respectively associated with at least two basic materials (mat1 . . . matM,mat?1 . . .Type: ApplicationFiled: June 21, 2019Publication date: December 26, 2019Applicant: Commissariat a l'energie atomique et aux energies alternativesInventors: Caroline PAULUS, Andrea BRAMBILLA, Veronique REBUFFEL
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Publication number: 20190033469Abstract: The invention is a method for processing a pulse generated by a detector of ionizing radiation, the detector being configured to interact with ionizing radiation in order to generate said pulse, the amplitude of which depends on an energy liberated by the ionizing radiation during its interaction in the detector, the method including the following steps: a) exposing the detector to a source of ionizing radiation so as to obtain, at a measurement time, a pulse called the measurement pulse; b) shaping the measurement pulse, using a first shaping time, and determining a first amplitude of the measurement pulse thus shaped; and c) correcting the first amplitude measured in step b), by taking into account a correction factor; the correction factor being determined by taking into account pulses, called pulses of interest, formed by the detector during an exposure to the source or to a calibration source, during a time range of interest.Type: ApplicationFiled: July 17, 2018Publication date: January 31, 2019Applicant: Commissariat a l'energie atomique et aux energies alternativesInventors: Andrea BRAMBILLA, Cinzia De Cesare
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Patent number: 9689994Abstract: A method correcting a measured spectrum of X radiation, according to a number of channels Nc, each channel i corresponding to an energy range between Ei and Ei+?Ei, including: determining function ?ti,j(k) determining size of temporal deviation ?t interval separating two interactions with energy Ei and Ej, stacking of which leads to a detected energy value Ek; determining, from the function ?ti,j(k), probability function Pi,j(k) that an event counted in a channel k corresponds to a stack of two interactions, respectively of energies Ei and Ej; determining, from the probability function Pi,j(k), a stack spectrum as a part of the measured spectrum that corresponds only to the stacks alone; and calculating or estimating at least a first corrected spectrum, by the difference between the measured spectrum and the stack spectrum.Type: GrantFiled: November 30, 2010Date of Patent: June 27, 2017Assignee: Commissariat à l'énergie atomique et aux énergies alternativesInventors: Jean Rinkel, Andrea Brambilla, Jean-Marc Dinten, Florent Mougel
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Publication number: 20160363442Abstract: A method for characterizing a sample, by estimating a plurality of characteristic thicknesses, each being associated with a calibration material, including acquiring an energy spectrum (Sech) transmitted through this sample, located in an X and/or gamma spectral band, naled spectrum transmitted through the sample; for each spectrum of a plurality of calibration spectra (Sbase(Lk; Ll)), calculating a likelihood from said calibration spectrum (Sbase(Lk; Ll)), and from the spectrum transmitted through the sample (Sech), each calibration spectrum (Sbase(Lk; Ll)) corresponding to the energy spectrum transmitted through a stack of gauge blocks, each formed of a known thickness of a calibration material; estimating the characteristic thicknesses (L1, L2) associated with the sample according to the criterion of maximum likelihood.Type: ApplicationFiled: June 14, 2016Publication date: December 15, 2016Applicant: Commissariat a L'Energie Atomique et aux Energies AlternativesInventors: Andrea BRAMBILLA, Alexia GORECKI, Alexandra POTOP
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Patent number: 9065432Abstract: A device that processes a signal delivered by a radiation detector includes a circuit that delivers a voltage pulse whose amplitude is proportional to a charge detected by the radiation detector. The device also includes an analog to digital converter to digitize the voltage pulse at a given sampling frequency and delivers a corresponding digital signal to a processing circuit. The processing circuit reads the digital signal, computes a temporal variation rate of the digital signal and captures the digital signal when the temporal variation reaches a threshold.Type: GrantFiled: October 27, 2010Date of Patent: June 23, 2015Assignee: Commissariat à l'énergie atomique et aux énergies alternativesInventors: Patrice Ouvrier-Buffet, Andrea Brambilla
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Patent number: 8748832Abstract: An ionizing radiation detection device including a detector of semi-conductor material intended to be biased thanks to electrodes, among which reading electrodes connected to a reading circuit process signals they provide to reject those causing a poor spectrometric response, that is those affected by an induction share and possibly those affected by a charge or electronic noise share.Type: GrantFiled: June 28, 2012Date of Patent: June 10, 2014Assignee: Commissariat a l'energie atomique et aux energies alternativesInventors: Andréa Brambilla, Patrice Ouvrier-Buffet
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Publication number: 20130168562Abstract: This invention relates to an ionizing radiation detection device including a detector (1) of semi-conductor material intended to be biased thanks to electrodes (3.1, 3.2), among which reading electrodes (3.2) connected to a reading circuit (2) process signals they provide to reject those causing a poor spectrometric response, that is those affected by an induction share and possibly those affected by a charge or electronic noise share.Type: ApplicationFiled: June 28, 2012Publication date: July 4, 2013Applicant: Commissariat a l'energie atomique et aux ene altInventors: Andrea Brambilla, Patrice Ouvrier-Buffet
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Publication number: 20130046500Abstract: A method correcting a measured spectrum of X radiation, according to a number of channels Nc, each channel i corresponding to an energy range between Ei and Ei+?Ei, including: determining function ?ti,j(k) determining size of temporal deviation ?t interval separating two interactions with energy Ei and Ej, stacking of which leads to a detected energy value Ek; determining, from the function ?ti,j(k), probability function Pi,j(k) that an event counted in a channel k corresponds to a stack of two interactions, respectively of energies Ei and Ej; determining, from the probability function Pi,j(k), a stack spectrum as a part of the measured spectrum that corresponds only to the stacks alone; and calculating or estimating at least a first corrected spectrum, by the difference between the measured spectrum and the stack spectrum.Type: ApplicationFiled: November 30, 2010Publication date: February 21, 2013Applicant: Commissariat a l'energie Atomique et aux Energies alternativesInventors: Jean Rinkel, Andrea Brambilla, Jean-Marc Dinten, Florent Mougel
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Publication number: 20110098980Abstract: The invention concerns a device for processing a signal delivered by a radiation detector (1), the device comprising a circuit (2, 3) able to deliver a voltage pulse whereof the amplitude is proportional to a charge detected by the detector (1) and an analog/digital converter (ADC) that digitizes the voltage pulse at a given sampling frequency and delivers a digital signal, characterized in that it comprises, downstream of the analog/digital converter (ADC), a processing circuit (5) that comprises: a reading unit for reading the digital signal (S (t)) delivered by the analog/digital converter (ADC), a computing unit that computes a temporal variation rate of the read digital signals, and a circuit able to capture the read digital signals whereof the temporal variation reaches a predetermined threshold.Type: ApplicationFiled: October 27, 2010Publication date: April 28, 2011Applicant: COMMISSARIAT A L' ENERGIE ATOMIQUEInventors: Patrice OUVRIER-BUFFET, Andrea Brambilla
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Patent number: 7825385Abstract: This device for detecting electromagnetic radiation, in particular X-ray or ?-rays, includes: a sensing layer consisting of at least one material capable of interacting with said electromagnetic radiation to be detected, in order to liberate mobile charge carriers, whereof the movement generates an electric current; a substrate provided with a plurality of elementary collectors of the charge carriers thus liberated, said elementary collectors being distributed discretely; a transfer layer suitable for transferring the charge carriers liberated by the sensing layer at the elementary collectors, said layer being connected to the sensing layer; and an insulating adhesive mating layer, suitable for mating the plurality of elementary collectors and the transfer layer.Type: GrantFiled: December 17, 2008Date of Patent: November 2, 2010Assignee: Commissariat à l'Energie AtomiqueInventors: Adrien Gasse, Marc Arques, Lydie Mathieu, Andrea Brambilla
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Publication number: 20090166544Abstract: This device for detecting electromagnetic radiation, in particular X-ray or ?-rays, includes: a sensing layer consisting of at least one material capable of interacting with said electromagnetic radiation to be detected, in order to liberate mobile charge carriers, whereof the movement generates an electric current; a substrate provided with a plurality of elementary collectors of the charge carriers thus liberated, said elementary collectors being distributed discretely; a transfer layer suitable for transferring the charge carriers liberated by the sensing layer at the elementary collectors, said layer being connected to the sensing layer; and an insulating adhesive mating layer, suitable for mating the plurality of elementary collectors and the transfer layer.Type: ApplicationFiled: December 17, 2008Publication date: July 2, 2009Applicant: Commissariat A L'Energie AtomiqueInventors: Adrien Gasse, Marc Arques, Lydie Mathieu, Andrea Brambilla
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Publication number: 20080038550Abstract: A thermoadhesive tape particularly but not exclusively intended for the manufacture of stitch-free items, like for example garments and clothing accessories, comprises weft and warp and at least one filament of thermoadhesive fibre woven with the weft and warp.Type: ApplicationFiled: December 28, 2006Publication date: February 14, 2008Inventor: Andrea Brambilla
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Publication number: 20070287006Abstract: A thermoadhesive tape comprises weft and warp wherein at least one between the weft and warp comprises at least one filament of thermoadhesive fibre.Type: ApplicationFiled: May 10, 2007Publication date: December 13, 2007Inventor: Andrea Brambilla