Patents by Inventor Andrea Brambilla

Andrea Brambilla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11808565
    Abstract: A method is provided for characterizing a sample, by estimating a plurality of characteristic thicknesses, each being associated with a calibration material. The method includes acquiring an energy spectrum transmitted through the sample, located in an X and/or gamma spectral band; for each spectrum of a plurality of calibration spectra, calculating a likelihood from said calibration spectrum, and from the spectrum transmitted through the sample, each calibration spectrum corresponding to the energy spectrum transmitted through a stack of gauge blocks, each formed of a known thickness of a calibration material; and estimating the characteristic thicknesses associated with the sample according to the criterion of maximum likelihood.
    Type: Grant
    Filed: February 25, 2021
    Date of Patent: November 7, 2023
    Assignee: Commissariat a L'Energie Atomique et aux Energies Alternatives
    Inventors: Andrea Brambilla, Alexia Gorecki, Alexandra Potop
  • Patent number: 11639490
    Abstract: The invention discloses a device and method for producing and purifying exosomes from progenitor cells using a closed and sterile circuit having a pumping means and a plurality of serially connected processing stations.
    Type: Grant
    Filed: December 28, 2017
    Date of Patent: May 2, 2023
    Assignee: Foundation for Cardiological Research and Education (FCRE)
    Inventors: Gabriella Andriolo, Elena Provasi, Andrea Brambilla, Viviana Giovanna Lo Cicero, Sabrina Soncin, Lucio Barile, Lucia Turchetto, Marina Radrizzani, Giuseppe Vassalli
  • Publication number: 20210199429
    Abstract: The invention relates to a method for characterizing a sample, by estimating a plurality of characteristic thicknesses, each being associated with a calibration material, comprising the following steps: acquiring an energy spectrum (Sech) transmitted through this sample, located in an X and/or gamma spectral band, naled spectrum transmitted through the sample; for each spectrum of a plurality of calibration spectra (Sbase(Lk; Ll)), calculating a likelihood from said calibration spectrum (Sbase(Lk; Ll)), and from the spectrum transmitted through the sample (Sech), each calibration spectrum (Sbase(Lk; Ll)) corresponding to the energy spectrum transmitted through a stack of gauge blocks, each formed of a known thickness of a calibration material; estimating the characteristic thicknesses (L1, L2) associated with the sample according to the criterion of maximum likelihood.
    Type: Application
    Filed: February 25, 2021
    Publication date: July 1, 2021
    Applicant: Commissariat a L'Energie Atomique et aux Energies Alternatives
    Inventors: Andrea BRAMBILLA, Alexia GORECKI, Alexandra POTOP
  • Patent number: 10983070
    Abstract: The invention is a method for characterizing an object (20), comprising the following steps: a) placing the object between a radiation source (10) and a radiation detector (30); b) irradiating the object with the radiation source and detecting radiation transmitted by the object (14) using the radiation detector, the radiation detector defining a plurality of pixels; c) for each pixel (30i), forming an energy spectrum (Si) of the detected radiation, each spectrum comprising at least two distinct energy bands; d) from each spectrum formed in c), estimating, in each pixel, at least two equivalent thicknesses ({circumflex over (L)}i,1 . . . {circumflex over (L)}i,M,{circumflex over (L)}?i,1 . . . {circumflex over (L)}?i,M) respectively associated with at least two basic materials (mat1 . . . matM,mat?1 . . .
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: April 20, 2021
    Assignee: Commissariat a l'energie atomique et aux energies alternatives
    Inventors: Caroline Paulus, Andrea Brambilla, Veronique Rebuffel
  • Patent number: 10969220
    Abstract: A method for characterizing a sample, by estimating a plurality of characteristic thicknesses, each being associated with a calibration material, including acquiring an energy spectrum (Sech) transmitted through this sample, located in an X and/or gamma spectral band; for each spectrum of a plurality of calibration spectra (sbase(Lk; Lt)) calculating a likelihood from said calibration spectrum (Sbase(Lk; Lt)), and from the spectrum transmitted through the sample (Sech), each calibration spectrum (Sbase(Lk; Lt)) corresponding to the energy spectrum transmitted through a stack of gauge blocks, each formed of a known thickness of a calibration material; estimating the characteristic thicknesses (L1, L2) associated with the sample according to the criterion of maximum likelihood.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: April 6, 2021
    Assignee: Commissariat a L'Energie Atomique et aux Energies Alternatives
    Inventors: Andrea Brambilla, Alexia Gorecki, Alexandra Potop
  • Publication number: 20200283715
    Abstract: The invention discloses a device and method for producing and purifying exosomes from progenitor cells using a closed and sterile circuit having a pumping means and a plurality of serially connected processing stations.
    Type: Application
    Filed: December 28, 2017
    Publication date: September 10, 2020
    Applicant: LUGANO TECHNOLOGY TRANSFER (LTT) SA
    Inventors: Gabriella ANDRIOLO, Elena PROVASI, Andrea BRAMBILLA, Viviana Giovanna LO CICERO, Sabrina SONCIN, Lucio BARILE, Lucia TURCHETTO, Marina RADRIZZANI, Giuseppe VASSALLI
  • Patent number: 10641909
    Abstract: The invention is a method for processing a pulse generated by a detector of ionizing radiation, the detector being configured to interact with ionizing radiation in order to generate said pulse, the amplitude of which depends on an energy liberated by the ionizing radiation during its interaction in the detector, the method including the following steps: a) exposing the detector to a source of ionizing radiation so as to obtain, at a measurement time, a pulse called the measurement pulse; b) shaping the measurement pulse, using a first shaping time, and determining a first amplitude of the measurement pulse thus shaped; and c) correcting the first amplitude measured in step b), by taking into account a correction factor; the correction factor being determined by taking into account pulses, called pulses of interest, formed by the detector during an exposure to the source or to a calibration source, during a time range of interest.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: May 5, 2020
    Assignee: Commissariat a l'energie atomique et aux energies alternatives
    Inventors: Andrea Brambilla, Cinzia De Cesare
  • Publication number: 20190391090
    Abstract: The invention is a method for characterizing an object (20), comprising the following steps: a) placing the object between a radiation source (10) and a radiation detector (30); b) irradiating the object with the radiation source and detecting radiation transmitted by the object (14) using the radiation detector, the radiation detector defining a plurality of pixels; c) for each pixel (30i), forming an energy spectrum (Si) of the detected radiation, each spectrum comprising at least two distinct energy bands; d) from each spectrum formed in c), estimating, in each pixel, at least two equivalent thicknesses ({circumflex over (L)}i,1 . . . {circumflex over (L)}i,M,{circumflex over (L)}?i,1 . . . {circumflex over (L)}?i,M) respectively associated with at least two basic materials (mat1 . . . matM,mat?1 . . .
    Type: Application
    Filed: June 21, 2019
    Publication date: December 26, 2019
    Applicant: Commissariat a l'energie atomique et aux energies alternatives
    Inventors: Caroline PAULUS, Andrea BRAMBILLA, Veronique REBUFFEL
  • Publication number: 20190033469
    Abstract: The invention is a method for processing a pulse generated by a detector of ionizing radiation, the detector being configured to interact with ionizing radiation in order to generate said pulse, the amplitude of which depends on an energy liberated by the ionizing radiation during its interaction in the detector, the method including the following steps: a) exposing the detector to a source of ionizing radiation so as to obtain, at a measurement time, a pulse called the measurement pulse; b) shaping the measurement pulse, using a first shaping time, and determining a first amplitude of the measurement pulse thus shaped; and c) correcting the first amplitude measured in step b), by taking into account a correction factor; the correction factor being determined by taking into account pulses, called pulses of interest, formed by the detector during an exposure to the source or to a calibration source, during a time range of interest.
    Type: Application
    Filed: July 17, 2018
    Publication date: January 31, 2019
    Applicant: Commissariat a l'energie atomique et aux energies alternatives
    Inventors: Andrea BRAMBILLA, Cinzia De Cesare
  • Patent number: 9689994
    Abstract: A method correcting a measured spectrum of X radiation, according to a number of channels Nc, each channel i corresponding to an energy range between Ei and Ei+?Ei, including: determining function ?ti,j(k) determining size of temporal deviation ?t interval separating two interactions with energy Ei and Ej, stacking of which leads to a detected energy value Ek; determining, from the function ?ti,j(k), probability function Pi,j(k) that an event counted in a channel k corresponds to a stack of two interactions, respectively of energies Ei and Ej; determining, from the probability function Pi,j(k), a stack spectrum as a part of the measured spectrum that corresponds only to the stacks alone; and calculating or estimating at least a first corrected spectrum, by the difference between the measured spectrum and the stack spectrum.
    Type: Grant
    Filed: November 30, 2010
    Date of Patent: June 27, 2017
    Assignee: Commissariat à l'énergie atomique et aux énergies alternatives
    Inventors: Jean Rinkel, Andrea Brambilla, Jean-Marc Dinten, Florent Mougel
  • Publication number: 20160363442
    Abstract: A method for characterizing a sample, by estimating a plurality of characteristic thicknesses, each being associated with a calibration material, including acquiring an energy spectrum (Sech) transmitted through this sample, located in an X and/or gamma spectral band, naled spectrum transmitted through the sample; for each spectrum of a plurality of calibration spectra (Sbase(Lk; Ll)), calculating a likelihood from said calibration spectrum (Sbase(Lk; Ll)), and from the spectrum transmitted through the sample (Sech), each calibration spectrum (Sbase(Lk; Ll)) corresponding to the energy spectrum transmitted through a stack of gauge blocks, each formed of a known thickness of a calibration material; estimating the characteristic thicknesses (L1, L2) associated with the sample according to the criterion of maximum likelihood.
    Type: Application
    Filed: June 14, 2016
    Publication date: December 15, 2016
    Applicant: Commissariat a L'Energie Atomique et aux Energies Alternatives
    Inventors: Andrea BRAMBILLA, Alexia GORECKI, Alexandra POTOP
  • Patent number: 9065432
    Abstract: A device that processes a signal delivered by a radiation detector includes a circuit that delivers a voltage pulse whose amplitude is proportional to a charge detected by the radiation detector. The device also includes an analog to digital converter to digitize the voltage pulse at a given sampling frequency and delivers a corresponding digital signal to a processing circuit. The processing circuit reads the digital signal, computes a temporal variation rate of the digital signal and captures the digital signal when the temporal variation reaches a threshold.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: June 23, 2015
    Assignee: Commissariat à l'énergie atomique et aux énergies alternatives
    Inventors: Patrice Ouvrier-Buffet, Andrea Brambilla
  • Patent number: 8748832
    Abstract: An ionizing radiation detection device including a detector of semi-conductor material intended to be biased thanks to electrodes, among which reading electrodes connected to a reading circuit process signals they provide to reject those causing a poor spectrometric response, that is those affected by an induction share and possibly those affected by a charge or electronic noise share.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: June 10, 2014
    Assignee: Commissariat a l'energie atomique et aux energies alternatives
    Inventors: Andréa Brambilla, Patrice Ouvrier-Buffet
  • Publication number: 20130168562
    Abstract: This invention relates to an ionizing radiation detection device including a detector (1) of semi-conductor material intended to be biased thanks to electrodes (3.1, 3.2), among which reading electrodes (3.2) connected to a reading circuit (2) process signals they provide to reject those causing a poor spectrometric response, that is those affected by an induction share and possibly those affected by a charge or electronic noise share.
    Type: Application
    Filed: June 28, 2012
    Publication date: July 4, 2013
    Applicant: Commissariat a l'energie atomique et aux ene alt
    Inventors: Andrea Brambilla, Patrice Ouvrier-Buffet
  • Publication number: 20130046500
    Abstract: A method correcting a measured spectrum of X radiation, according to a number of channels Nc, each channel i corresponding to an energy range between Ei and Ei+?Ei, including: determining function ?ti,j(k) determining size of temporal deviation ?t interval separating two interactions with energy Ei and Ej, stacking of which leads to a detected energy value Ek; determining, from the function ?ti,j(k), probability function Pi,j(k) that an event counted in a channel k corresponds to a stack of two interactions, respectively of energies Ei and Ej; determining, from the probability function Pi,j(k), a stack spectrum as a part of the measured spectrum that corresponds only to the stacks alone; and calculating or estimating at least a first corrected spectrum, by the difference between the measured spectrum and the stack spectrum.
    Type: Application
    Filed: November 30, 2010
    Publication date: February 21, 2013
    Applicant: Commissariat a l'energie Atomique et aux Energies alternatives
    Inventors: Jean Rinkel, Andrea Brambilla, Jean-Marc Dinten, Florent Mougel
  • Publication number: 20110098980
    Abstract: The invention concerns a device for processing a signal delivered by a radiation detector (1), the device comprising a circuit (2, 3) able to deliver a voltage pulse whereof the amplitude is proportional to a charge detected by the detector (1) and an analog/digital converter (ADC) that digitizes the voltage pulse at a given sampling frequency and delivers a digital signal, characterized in that it comprises, downstream of the analog/digital converter (ADC), a processing circuit (5) that comprises: a reading unit for reading the digital signal (S (t)) delivered by the analog/digital converter (ADC), a computing unit that computes a temporal variation rate of the read digital signals, and a circuit able to capture the read digital signals whereof the temporal variation reaches a predetermined threshold.
    Type: Application
    Filed: October 27, 2010
    Publication date: April 28, 2011
    Applicant: COMMISSARIAT A L' ENERGIE ATOMIQUE
    Inventors: Patrice OUVRIER-BUFFET, Andrea Brambilla
  • Patent number: 7825385
    Abstract: This device for detecting electromagnetic radiation, in particular X-ray or ?-rays, includes: a sensing layer consisting of at least one material capable of interacting with said electromagnetic radiation to be detected, in order to liberate mobile charge carriers, whereof the movement generates an electric current; a substrate provided with a plurality of elementary collectors of the charge carriers thus liberated, said elementary collectors being distributed discretely; a transfer layer suitable for transferring the charge carriers liberated by the sensing layer at the elementary collectors, said layer being connected to the sensing layer; and an insulating adhesive mating layer, suitable for mating the plurality of elementary collectors and the transfer layer.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: November 2, 2010
    Assignee: Commissariat à l'Energie Atomique
    Inventors: Adrien Gasse, Marc Arques, Lydie Mathieu, Andrea Brambilla
  • Publication number: 20090166544
    Abstract: This device for detecting electromagnetic radiation, in particular X-ray or ?-rays, includes: a sensing layer consisting of at least one material capable of interacting with said electromagnetic radiation to be detected, in order to liberate mobile charge carriers, whereof the movement generates an electric current; a substrate provided with a plurality of elementary collectors of the charge carriers thus liberated, said elementary collectors being distributed discretely; a transfer layer suitable for transferring the charge carriers liberated by the sensing layer at the elementary collectors, said layer being connected to the sensing layer; and an insulating adhesive mating layer, suitable for mating the plurality of elementary collectors and the transfer layer.
    Type: Application
    Filed: December 17, 2008
    Publication date: July 2, 2009
    Applicant: Commissariat A L'Energie Atomique
    Inventors: Adrien Gasse, Marc Arques, Lydie Mathieu, Andrea Brambilla
  • Publication number: 20080038550
    Abstract: A thermoadhesive tape particularly but not exclusively intended for the manufacture of stitch-free items, like for example garments and clothing accessories, comprises weft and warp and at least one filament of thermoadhesive fibre woven with the weft and warp.
    Type: Application
    Filed: December 28, 2006
    Publication date: February 14, 2008
    Inventor: Andrea Brambilla
  • Publication number: 20070287006
    Abstract: A thermoadhesive tape comprises weft and warp wherein at least one between the weft and warp comprises at least one filament of thermoadhesive fibre.
    Type: Application
    Filed: May 10, 2007
    Publication date: December 13, 2007
    Inventor: Andrea Brambilla