Abstract: The present invention relates to a lysosomal protein composition comprising a plurality of lysosomal proteins that are potentially diversely glycosylated according to a glycosylation pattern, wherein said glycosylation pattern has at least 45% paucimannosidic N-glycans; a method of manufacturing the lysosomal protein composition in a bryophyte plant or cell, and medical and non-medical uses of the lysosomal protein composition. E.g. the lysosomal protein can be ?-Galactosidase for the treatment of Fabry Disease or ?-Glucoceramidase for the treatment of Gaucher's Disease. The unique glycosylation results in improved therapeutic efficacy—surprisingly even without mannose-6-phosphate that is common for CHO cell produced lysosomal proteins.

Abstract: The invention concerns a method for detaching expressed material from the surface or from the apoplast of plant cells, wherein the plant cells are treated with a rotor-stator in a liquid medium, wherein the specific heat from the rotor-stator introduced by rotation of the rotor is a maximum of 3 kJ per kg of the liquid medium and per g/L dry weight of the plant cells and the specific heat capacity introduced into the medium is a maximum of 1.5 kJ per kg of the liquid medium per minute and per g/L dry weight of the plant cells.

Abstract: A device at properly aligns a user's hand when gripping a writing implement, such as pencil. The device includes four separate elements that combine in specific ways to grow and/or build a mature grasp. The device includes a base that is configure round the pencil and provides support for the user's fingers. A handle can releasably attach to the writing implement, providing support for the user's palm. A web support can be releasably attached to the handle, thereby stabilizing the user's thumb while gripping the writing implement. The device can also include an independent web positioner support that can be moved closer or towards the base depending on the separation needed. Advantageously, the grip device provides several stages to develop and build a mature grip pattern.

Abstract: The present invention relates to a lysosomal protein composition comprising a plurality of lysosomal proteins that are potentially diversely glycosylated according to a glycosylation pattern, wherein said glycosylation pattern has at least 45% paucimannosidic N-glycans; a method of manufacturing the lysosomal protein composition in a bryophyte plant or cell, and medical and non-medical uses of the lysosomal protein composition. E.g. the lysosomal protein can be ?-Galactosidase for the treatment of Fabry Disease or ?-Glucoceramidase for the treatment of Gaucher's Disease. The unique glycosylation results in improved therapeutic efficacy—surprisingly even without mannose-6-phosphate that is common for CHO cell produced lysosomal proteins.

Abstract: The invention is directed to a device that properly aligns a user's hand when gripping a writing implement, such as a pencil. The device includes four separate elements that combine in specific ways to grow and/or build a mature grasp. The device includes a base that is configured around the pencil and provides support for the user's fingers. A handle can releasably attach to the writing implement, providing support for the user's palm. A web support can be releasably attached to the handle, thereby stabilizing the user's thumb while gripping the writing implement. The device can also include an independent web support that can be moved closer or towards the base depending on the separation needed. Advantageously, the grip device provides several stages to develop and build a mature grip pattern.

Abstract: The present invention relates to a lysosomal protein composition comprising a plurality of lysosomal proteins that are potentially diversely glycosylated according to a glycosylation pattern, wherein said glycosylation pattern has at least 45% paucimannosidic N-glycans; a method of manufacturing the lysosomal protein composition in a bryophyte plant or cell, and medical and non-medical uses of the lysosomal protein composition. E.g. the lysosomal protein can be a-Galactosidase for the treatment of Fabry Disease or ?-Glucoceramidase for the treatment of Gaucher's Disease. The unique glycosylation results in improved therapeutic efficacy—surprisingly even without mannose-6-phosphate that is common for CHO cell produced lysosomal proteins.

Abstract: A luggage conveyor device for efficiently supplying a plurality of inspection objects to be inspected or individual items in general to an inspection device (4) is provided. The conveyor device (1, 2, 3) is particularly efficiently designed such that an inspection object inspection is carried out quickly and smoothly. A correspondingly designed method for operating the conveyor device (1, 2, 3), and to a computer program product including control commands for implementing the method or operating the conveyor device (1, 2, 3) are also provided.

Abstract: The disclosure relates to a luggage conveyor device (1, 2, 3) for efficiently supplying a plurality of inspection objects to be inspected or individual items in general to an inspection device (4). According to the disclosure, the conveyor device (1, 2, 3) is particularly efficiently designed such that an inspection object inspection is carried out quickly and smoothly. The disclosure also relates to a correspondingly designed method for operating said conveyor device (1, 2, 3), and to a computer programme product including control commands for implementing the method or operating the conveyor device (1, 2, 3).

Abstract: The present invention relates to a lysosomal protein composition comprising a plurality of lysosomal proteins that are potentially diversely glycosylated according to a glycosylation pattern, wherein said glycosylation pattern has at least 45% paucimannosidic N-glycans; a method of manufacturing the lysosomal protein composition in a bryophyte plant or cell, and medical and non-medical uses of the lysosomal protein composition. E.g. the lysosomal protein can be a-Galactosidase for the treatment of Fabry Disease or ?-Glucoceramidase for the treatment of Gaucher's Disease. The unique glycosylation results in improved therapeutic efficacy—surprisingly even without mannose-6-phosphate that is common for CHO cell produced lysosomal proteins.

Abstract: A sensor mounting for a sensor for object detection includes a housing for the sensor, a holder on which the housing is pivotably held, an adjusting device for an angular orientation of the housing and an angular gear mechanism for controlling the adjusting device. The angular gear mechanism includes a drive wheel and a driven wheel, the drive wheel being connected to an engagement contour for the transmission of torque to the drive wheel, and a gear mechanism housing of the angular gear mechanism being set up so as to permit mounting of the drive wheel at different sides of the angular gear mechanism.

Abstract: A metal reinforcement for a B-pillar of an automotive vehicle includes a lower flange and an upper structure. The lower flange is adapted to adjoin a door sill structure of the automotive vehicle, and the upper structure includes a central portion, surrounded by a plurality of spaced, paired regions. In each paired region, members are identically ordered in position from the central portion, and both members of each paired region have the same profile thickness.

Abstract: A sensor mounting for a sensor for object detection includes a housing for the sensor, a holder on which the housing is pivotably held, an adjusting device for an angular orientation of the housing and an angular gear mechanism for controlling the adjusting device. The angular gear mechanism includes a drive wheel and a driven wheel, the drive wheel being connected to an engagement contour for the transmission of torque to the drive wheel, and a gear mechanism housing of the angular gear mechanism being set up so as to permit mounting of the drive wheel at different sides of the angular gear mechanism.

Abstract: A metal reinforcement for a B-pillar of an automotive vehicle includes a lower flange and an upper structure. The lower flange is adapted to adjoin a door sill structure of the automotive vehicle, and the upper structure includes a central portion, surrounded by a plurality of spaced, paired regions. In each paired region, members are identically ordered in position from the central portion, and both members of each paired region have the same profile thickness.

Abstract: The invention relates to a hydrogen sensor with a radiation source, by means of which electromagnetic radiation is radiated onto a sensor medium, wherein the sensor medium has a transmission coefficient that varies as a function of the concentration of hydrogen in the environment of the sensor medium, and with a detector that detects at least a portion of the radiation transported through the sensor medium. The hydrogen sensor according to the invention is characterized by the fact that a reflector is provided that reflects the radiation transmitted through the sensor medium back to the sensor medium. The hydrogen sensor according to the invention is further characterized by the fact that the sensor medium incorporates clusters containing or consisting of a palladium alloy, yttrium, scandium, at least one lanthanide, at least one actinoide, tungsten oxide and/or vanadium oxide, and/or a mixture or compound of these materials.

Abstract: A method for evaluating contamination measurement values of solid particle (6) contamination in fluids in a system (1), in particular in hydraulic and/or lubricating fluids, wherein said contamination measurement values being represented by counting, within a volume of said fluid, at least one number of particles (6) having a particle size in at least one predetermined particle size range, said method for evaluating comprising the steps of: comparing said counted number with at least one predetermined threshold value (22, 24, W, A, S) resulting in a present comparison result, reading a previous comparison result corresponding to a previous counted number from a history file, choosing an appropriate control signal to control said system (1), said choice being based on said present comparison result and at least one previous comparison result.

Abstract: The invention relates to a method for identifying a compound which modifies the activity of the urotensin II receptor, with genes or gene products which are involved in the structure, formation or breakdown of the extracellular matrix being influenced.

Abstract: A device for separating fluid mixtures, in particular for separating water from oil, includes a vacuum container (10) with several sub-chambers (26, 44, 40). At least one liquid constituent of the fluid mixture can be transported from the vacuum container after separation, by a transport device (12). The other constituents can be extracted from the vacuum container (10) in the form of gas and/or steam, using a vacuum pump (20). One of the sub-chambers (26) of the vacuum container (10) houses a heating device (28, 30), which heats the fluid mixture. The fluid mixture is guided into an additional sub-chamber (40), and is separated into its constituents by traversing a packed bed. Even cold and consequently viscous fluid mixtures can be supplied, due to the heating device, for separation inside the aforementioned vacuum container.

Abstract: The invention relates to a device for separating fluid mixtures, in particular for separating water from oil, comprising a vacuum container (10) with several sub-chambers (26, 44, 40). According to the invention, at least one liquid constituent of the fluid mixture can be transported from the vacuum container after separation, by means of a transport device (12) and the other constituents can be extracted from the vacuum container (10) in the form of gas and/or steam, using a vacuum pump (20). One of the sub-chambers (26) of the vacuum container (10) houses a heating device (28, 30), which heats the fluid mixture, the latter being guided into an additional sub-chamber (40) and being separated into its constituents by traversing a packed bed. The invention therefore allows even cold and consequently viscous fluid mixtures to be supplied, by means of the heating device, for separation inside the aforementioned vacuum container.

Abstract: The invention relates to a method for identifying a compound which modifies the activity of the urotensin II receptor, with genes or gene products which are involved in the structure, formation or breakdown of the extracellular matrix being influenced.

Abstract: Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or a diagnostic, and medicament comprising them Chromans of the formula I and of the formula 1a having the meanings R(A), R(B), R(C) and R(1) to R(8) indicated in the claims are outstandingly suitable for preparing a medicament for blocking the K+ channel which is opened by cyclic adenosine monophosphate (cAMP); and further for preparing a medicament for inhibiting gastric acid secretion; for the treatment of ulcers of the stomach and of the intestinal region, in particular of the duodenum, for the treatment of reflux esophagitis, for the treatment of diarrheal illnesses, for the treatment and prevention of all types of arrhythmias including ventricular and supraventricular arrhythmias, and for the control of reentry arrhythmias and for the prevention of sudden heart death as a result of ventricular fibrillation.