Abstract: The present disclosure relates, in part, to anti-influenza antibodies (and antigen binding fragments thereof) and combinations thereof for preventing and treating influenza infection. Presently disclosed combinations provide surprising synergistic effects and can potently prevent, inhibit, or neutralize an influenza infection, such as an influenza A virus (IAV) infection an influenza B virus (IBV) infection, or both.

Abstract: The present disclosure is directed to a monoclonal antibody, or antigen-binding fragment thereof, that specifically binds to a Staphylococcus aureus clumping factor A protein (ClfA), as well as compositions comprising the monoclonal antibody. The disclosure also is directed to methods of treating a Staphylococcus aureus infection by administering the anti-ClfA monoclonal antibody alone, or in combination with a monoclonal antibody that specifically binds to S. aureus alpha toxin (AT) protein to a subject. Bispecific monoclonal antibodies that specifically bind to both ClfA and AT and methods of using the same also are provided.

Abstract: The instant disclosure provides antibodies and antigen-binding fragments thereof that can bind to an influenza virus neuraminidase (NA) and can neutralize an influenza virus infection. Also provided are polynucleotides that encode an antibody, vectors that comprise such polynucleotides, host cells that can express the antibodies, related compositions, and methods of using the herein disclosed compositions to, for example, treat or prevent an influenza infection.

Abstract: A method of provisioning a control plane in a multi-technology network in response to a first connection request received from a client. The method comprises receiving the first connection request at a control plane dispatcher; analysing said first connection request and selecting a control plane based on results of the analysis and characteristics of control planes at the disposal of the dispatcher in the multi-technology network. The control plane dispatcher selects on a per connection request basis what is the best technology for that request and its requirements, taking also into account the status of the network resources.

Abstract: For protecting traffic on paths extending from a source client entity (CE1) to a destination client entity (CE2) via an optical transport network and attachment circuits at ingress (A,B) and egress (C,D) nodes, there are multiple paths within the OTN network, and the attachment circuits are dual homed. By sending (120) an indication of operational status of the dual homed attachment circuits within overhead associated with the traffic and sent with the traffic through the network, a selection can be made (130) of which of the provided paths and attachment circuits to use for the traffic, based on the indicated operational status, and on OTN fault detection, to protect against a fault in the attachment circuit or in the OTN network. Thus protection can extend across the edge nodes without the complexity and delays involved in interworking of separate protection schemes and without a control plane.

Abstract: For protecting traffic from a source client entity (CE1) to a destination client entity (CE2) via an optical transport network and attachment circuits at ingress (A,B) and egress (C,D) nodes, there are multiple paths within the OTN, and the attachment circuits are dual homed. By sending (120) an indication of operational status of the dual homed attachment circuits within overhead associated with the traffic and sent with the traffic through the network, a selection can be made (130) of which of the provided paths and attachment circuits to use for the traffic, based on the indicated operational status, and on OTN fault detection, to protect against a fault. Thus protection can extend across the edge nodes without interworking of separate protection schemes and without a control plane. Traffic flows can be multiplexed at the ingress, with the indication in the overhead having separate indications for each of the traffic flows.

Abstract: A method of provisioning a control plane in a multi-technology network in response to a first connection request received from a client. The method comprises receiving the first connection request at a control plane dispatcher; analysing said first connection request and selecting a control plane based on results of the analysis and characteristics of control planes at the disposal of the dispatcher in the multi-technology network. The control plane dispatcher selects on a per connection request basis what is the best technology for that request and its requirements, taking also into account the status of the network resources.

Abstract: The invention relates to a method of fault monitoring in a fault monitoring entity of a network node of a network having at least a first connection-oriented network layer, having first protection measures associated therewith, and a second connection-oriented network layer, having second protection measures associated therewith. In a first step the service condition status of the first network layer is monitored using the first protection measures. In a second step the second network layer protection measures are determined for onward transmission within the second network layer depending on the service condition status of the first network layer. Since the network node is aware of the monitored status condition of both the first and second layers the protection mechanisms for the first network layer and the second network layer can be co-ordinated and the second network layer protection measure for onward transmission may be determined for optimum network fault protection operation.

Abstract: Method of re-routing traffic in a communications network (1) in the event of a fault (3) on a path across the network, the method comprising, determining whether a first node (4), located between the fault and a network ingress node (6), is capable of switching traffic to an alternative path which avoids the fault, and if the first node is determined to be not so capable, then determining whether a second node (8), located upstream of the first node, is capable of switching traffic to an alternative path which avoids the fault.

Abstract: For protecting traffic from a source client entity (CE1) to a destination client entity (CE2) via an optical transport network and attachment circuits at ingress (A,B) and egress (C,D) nodes, there are multiple paths within the OTN, and the attachment circuits are dual homed. By sending (120) an indication of operational status of the dual homed attachment circuits within overhead associated with the traffic and sent with the traffic through the network, a selection can be made (130) of which of the provided paths and attachment circuits to use for the traffic, based on the indicated operational status, and on OTN fault detection, to protect against a fault. Thus protection can extend across the edge nodes without interworking of separate protection schemes and without a control plane. Traffic flows can be multiplexed at the ingress, with the indication in the overhead having separate indications for each of the traffic flows.

Abstract: A connection-oriented network (5) has a plurality of connections terminated at a first node (N6). A recovery group (A) is configured at the first node (N6) comprising at least two of the plurality of connections (LSP1-6, LSP2-6, LSP3-6, LSP4-6). Fault detection is performed over each of the connections in the recovery group (A) and the node determines if at least one recovery group fault condition is met, based on the results of the fault detections performed over the connections in the recovery-group (A). When the at least one recovery group fault condition is met, the node causes traffic on the plurality of connections in the recovery group (A) to be transferred to backup paths. When the at least one recovery group fault condition is not met, and a fault has been detected on a connection in the recovery group (A), the node causes traffic to be transferred from that connection to a backup path.

Abstract: For protecting traffic on paths extending from a source client entity (CE1) to a destination client entity (CE2) via an optical transport network and attachment circuits at ingress (A,B) and egress (C,D) nodes, there are multiple paths within the OTN network, and the attachment circuits are dual homed. By sending (120) an indication of operational status of the dual homed attachment circuits within overhead associated with the traffic and sent with the traffic through the network, a selection can be made (130) of which of the provided paths and attachment circuits to use for the traffic, based on the indicated operational status, and on OTN fault detection, to protect against a fault in the attachment circuit or in the OTN network. Thus protection can extend across the edge nodes without the complexity and delays involved in interworking of separate protection schemes and without a control plane.

Abstract: A real-time drive assistance system and method are provided. The system includes a centralized architecture capable of determining and preventing, in real time, potentially dangerous road situations, increasing road safety. The system is based on a communication network obtained through specific portable mobile communication devices exchanging information related to the state of a plurality of vehicles in motion along a road network. The method includes periodical acquisition and sending of the information to a centralized processing unit using the wireless communication system of each portable mobile communication device; processing of the information in order to verify the occurrence of potential dangerous situations for the drivers of each vehicle; and sending of warning or danger signals to one or more of the portable mobile communication devices that can alert the drivers of the vehicles.

Abstract: The invention relates in general to a communications network, and more particularly, to methods and apparatus for protecting such a network. The methods and apparatus disclose the providision path protection in a communications network (14) having a plurality of nodes including at least one access node (24, 26, 28, 30). A connection-oriented worker path (23) is set up between a first distribution node (22) and the at least one access node. A connection-oriented protection path (21) is also set up between a second distribution node and the at least one access node. A connection-oriented interface path (52) is also set up between the first and second distribution nodes. Traffic from an upstream node (16, 18) is switched to the interface path (52) at one of the distribution nodes (20, 22). Traffic may be switched to the protection path (21) in response to detecting a fault (54) in the worker path.

Abstract: A motor-vehicle driving style estimating system (100) of a motor-vehicle, comprising a measuring apparatus (1) of a kinematic signal representative of a motor-vehicle motion quantity trend (v(t)). The system is characterized in that it further comprises a kinematic signal low-pass filtering module (8) configured to provide a corresponding reference filtered signal associated with a reference trend of said quantity (vF(t)). Furthermore, the system comprises a kinematic signal and reference filtered signal processing module (2) configured to provide an indication of the driving style depending on a comparison of the motor-vehicle motion trend with the reference trend.

Abstract: A connection oriented communications network has a plurality of nodes including a plurality of edge nodes. The network is arranged to define a primary tunnel connecting a primary one of the edge nodes to another edge node and a secondary tunnel connecting a secondary one of the edge nodes to another edge node. The network is arranged to enable switching of traffic from the primary tunnel to the secondary tunnel in the event of detection of a failure in the primary tunnel.

Abstract: A method and a transport scheme for packets of traffic over a logical link made up of the aggregation of several physical links (16) connecting a transmitting side to a receiving side in which flows of incoming packets are sent to a scheduler/shaper (12) which selects therefrom packets for creating a global flow of packets falling within the bandwidth offered by the logical link on the basis of the bandwidth capability offered by the logical link. A distributor (13) distributes the global flow over the plurality of physical links (16) making up the logical link, oversees the physical links and sends to the scheduler/shaper signalling of a bandwidth decrease caused by failures of one or more physical links. The scheduler/shaper (12) is arranged to allow automatically for the logical link bandwidth variations while selecting the packets from the various incoming queues depending on the associated service class so as to cause the global flow to fall within the aggregated logical link bandwidth.

Abstract: There are described a real-time drive assistance system and method. The system proposes a centralized architecture capable of determining and preventing, in real time, potentially dangerous road situations, increasing road safety. The system is based on a communication network obtained through specific portable mobile communication devices (16) capable of exchanging information related to the state of a plurality of vehicles (12) in motion along a road network, with a single centralized processing unit (10).

Abstract: Zero valent metal composite, manufacturing thereof, using thereof, and system including thereof, for (in-situ or ex-situ) catalytically treating contaminated water, such as sub-surface water, surface water, above-surface water, water vapor, or/and gaseous water. Composite includes powdered diatomite matrix incorporated with nanometer (1-1000 nm) sized particles of a zero valent (transition) metal (iron, cobalt, nickel, copper, zinc, palladium, platinum, or/and gold) and at least one electron transfer mediator (catalyst) from porphyrinogenic organometallic complexes (e.g., metalloporphyrins (chlorophylls, hemes, cytochromes) or metallocorrins (e.g., vitamin B12), and optionally, includes vermiculite. System includes composite and in-situ or/and ex-situ unit containing the composite, enabling exposure of contaminated water thereto. Applicable to in-situ sub-surface permeable reactive barriers (PRBs).

Abstract: Zero valent metal composite, manufacturing thereof, using thereof, and system including thereof, for (in-situ or ex-situ) catalytically treating contaminated water, such as sub-surface water, surface water, above-surface water, water vapor, or/and gaseous water. Composite includes powdered diatomite matrix incorporated with nanometer (1-1000 nm) sized particles of a zero valent (transition) metal (iron, cobalt, nickel, copper, zinc, palladium, platinum, or/and gold) and at least one electron transfer mediator (catalyst) from porphyrinogenic organometallic complexes (e.g., metalloporphyrins (chlorophylls, hemes, cytochromes) or metallocorrins (e.g., vitamin B12), and optionally, includes vermiculite. System includes composite and in-situ or/and ex-situ unit containing the composite, enabling exposure of contaminated water thereto. Applicable to in-situ sub-surface permeable reactive barriers (PRBs).