Patents by Inventor Andrea Crisanti

Andrea Crisanti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210127651
    Abstract: The invention relates to gene drives, and in particular to genetic sequences and constructs for use in a gene drive. The invention is especially concerned with ultra-conserved and ultra-constrained sequences for use as a gene drive target with the aim of overcoming the development of resistance to the drive. The invention is also concerned with methods of suppressing wild type arthropod populations by use of the gene drive construct described herein.
    Type: Application
    Filed: June 21, 2019
    Publication date: May 6, 2021
    Applicant: IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
    Inventors: Andrea Crisanti, Kyros Kyroi, Andrew Hammond
  • Publication number: 20170328892
    Abstract: The invention provides a method of quantifying multiple antigen-specific immunoglobulins in a test sample, the method comprising utilising a serial dilution of anti-immunoglobulin antibodies, fragments or derivatives thereof, immobilised on a solid support in combination with a serial dilution of a reference sample of immunoglobulin to generate multiple binding capacity curves. Such binding capacity curves are matched to specific dose response curves generated for each specific antigen to be tested using serum samples of known reactivity to those antigens to provide a calibration system that enables more accurate analysis of antigen-specific immunoglobulin in a sample. The invention also provides methods for calibrating a device suitable for assaying multiple antigen-specific immunoglobulins binding to multiple antigens or fragments thereof immobilised on a solid support. A multi-allergen test system and kits for use in the methods are also provided.
    Type: Application
    Filed: May 26, 2017
    Publication date: November 16, 2017
    Applicant: Microtest Matrices Limited
    Inventors: Andrea Crisanti, Mauro Maccari, Francesca Baldracchini
  • Patent number: 8735340
    Abstract: The subject invention pertains to a conjugate comprising: (a) a first region comprising the homeodomain of antennapedia or a variant thereof; and (b) a second region not naturally associated with the first region. In one embodiment, the second region of the conjugate comprises a protein of at least 100 amino acids.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: May 27, 2014
    Assignee: Trojan Technologies Limited
    Inventor: Andrea Crisanti
  • Publication number: 20140141995
    Abstract: The invention provides a method of quantifying multiple antigen-specific immunoglobulins in a test sample, the method comprising utilising a serial dilution of anti-immunoglobulin antibodies, fragments or derivatives thereof, immobilised on a solid support in combination with a serial dilution of a reference sample of immunoglobulin to generate multiple binding capacity curves. Such binding capacity curves are matched to specific dose response curves generated for each specific antigen to be tested using serum samples of known reactivity to those antigens to provide a calibration system that enables more accurate analysis of antigen-specific immunoglobulin in a sample. The invention also provides methods for calibrating a device suitable for assaying multiple antigen-specific immunoglobulins binding to multiple antigens or fragments thereof immobilised on a solid support. A multi-allergen test system and kits for use in the methods are also provided.
    Type: Application
    Filed: April 17, 2012
    Publication date: May 22, 2014
    Applicant: MICROTEST MATRICES LIMITED
    Inventors: Andrea Crisanti, Mauro Maccari, Francesca Baldracchini
  • Publication number: 20130079237
    Abstract: The present invention relates to a method of assessing if a subject is at risk of developing or has already developed asthma, conjunctivitis or rhinitis. The invention further relates to antigen sets for use in such methods including identifying other suitable antigens correlated with asthma, conjunctivitis or rhinitis.
    Type: Application
    Filed: February 16, 2011
    Publication date: March 28, 2013
    Inventors: Andrea Crisanti, Tania Dottorini
  • Publication number: 20110256168
    Abstract: The subject invention pertains to a conjugate comprising: (a) a first region comprising the homeodomain of antennapedia or a variant thereof; and (b) a second region not naturally associated with the first region. In one embodiment, the second region of the conjugate comprises a protein of at least 100 amino acids.
    Type: Application
    Filed: June 24, 2011
    Publication date: October 20, 2011
    Inventor: Andrea Crisanti
  • Patent number: 7968512
    Abstract: The subject invention pertains to a conjugate comprising: (a) a first region comprising the homeodomain of antennapedia or a variant thereof; and (b) a second region not naturally associated with the first region. In one embodiment, the second region of the conjugate comprises a protein of at least 100 amino acids.
    Type: Grant
    Filed: February 27, 2004
    Date of Patent: June 28, 2011
    Assignee: Trojan Technologies Limited
    Inventor: Andrea Crisanti
  • Patent number: 7611669
    Abstract: The invention provides an assay device for quantification or detection of the presence or absence of an analyte in a liquid sample, comprising a molding (1) permanently or removably attached to a substantially planar plate (2) such that a part of said molding forms a capillary chamber (3) between said plate and the said molding, the device further comprising a chamber (5) into which a test sample and/or reagent can be introduced and further comprising a chamber (7) capable of accommodating an absorbent pad, wherein the said chamber into which a test sample and said chamber capable of holding an absorbent pad are in lateral flow contact via the said capillary chamber (3).
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: November 3, 2009
    Assignee: Imperial College Innovations Ltd.
    Inventors: Andrea Crisanti, Uri Friedlander, Tito Bacarese-Hamilton
  • Publication number: 20080317773
    Abstract: The subject invention pertains to a conjugate comprising: (a) a first region comprising the homeodomain of antennapedia or a variant thereof, and (b) a second region not naturally associated with the first region. In one embodiment, the second region of the conjugate comprises a protein of at least 100 amino acids.
    Type: Application
    Filed: February 27, 2004
    Publication date: December 25, 2008
    Inventor: Andrea Crisanti
  • Publication number: 20050225764
    Abstract: A device (100) for reading fluorescent signals comprising: an illuminator (110) for illuminating a material (130) bound with a fluorophore, at an appropriate wavelength to induce fluorescence; a detector (140) for detecting fluorescent signals emitted by the material (130); a signal processor for processing the signals detected; the device defining an optical system (170, 120, 240, 190, 180, 200, 150, 220, 210) having an excitation optical path and a detection optical path; characterised in that the illuminator (110) comprises a light emitting diode (LED), and in that the illumination illuminates all, or a substantial portion of the material (130) simultaneously.
    Type: Application
    Filed: April 24, 2003
    Publication date: October 13, 2005
    Inventors: Tito Bacarese-Hamilton, Andrea Crisanti, Uri Friedlander, Tony Canas, John Attridge, Philip Vessey
  • Publication number: 20040234527
    Abstract: Proteins that contain the amino acid sequence motif X1X1X2X3X1, where X1=R or K and X2 and X3=any amino acid have been found to translocate and can therefore be used in the manufacture of compositions for therapeutic applications. The proteins may also be used as translocation factors to deliver proteins or nucleic acids into a cell.
    Type: Application
    Filed: April 29, 2004
    Publication date: November 25, 2004
    Inventor: Andrea Crisanti
  • Publication number: 20040110928
    Abstract: A conjugate of a peptide capable of translocation across a cell membrane, and a therapeutic agent. The peptide comprises a defined amino acid sequence that provides the signal necessary for translocation.
    Type: Application
    Filed: April 15, 2003
    Publication date: June 10, 2004
    Inventors: Andrea Crisanti, Selma Esseghir
  • Publication number: 20040037821
    Abstract: A conjugate for controlling the expression of a gene comprises a nucleic acid-binding domain, a gene-regulating region and a factor that permits translocation of the conjugate across a cell membrane, wherein the nucleic acid-binding domain is heterologous to that naturally associated with the gene-regulating region, and binds to a conserved sequence on the gene.
    Type: Application
    Filed: July 21, 2003
    Publication date: February 26, 2004
    Inventors: Andrea Crisanti, Alison Mary Mortlock
  • Publication number: 20030125239
    Abstract: A serum-free composition comprises a conjugate of a DNA-binding protein, or a fragment thereof, and a polynucleotide. The composition is suitable for intramuscular administration, to treat disease.
    Type: Application
    Filed: September 30, 2002
    Publication date: July 3, 2003
    Inventors: Andrea Crisanti, Selma Esseghir
  • Publication number: 20030033622
    Abstract: A method for the genetic modification of an insect embryo, comprises first treating an insect egg under conditions which prevent or delay the hardening of the insect egg chorion, and then injecting a transposable element into the egg to permit integration of the element into the genome of the embryo. The method permits modifications to be made to mosquitoes, which may prevent transmission of a host parasite.
    Type: Application
    Filed: August 27, 2002
    Publication date: February 13, 2003
    Inventors: Andrea Crisanti, Catteruccia Flaminia, Tony Nolan
  • Patent number: D470595
    Type: Grant
    Filed: October 10, 2001
    Date of Patent: February 18, 2003
    Inventors: Andrea Crisanti, Uri Friedlander
  • Patent number: D500142
    Type: Grant
    Filed: October 10, 2001
    Date of Patent: December 21, 2004
    Inventors: Andrea Crisanti, Uri Friedlander