Abstract: Antimicrobial compositions comprising at least an amine-based antimicrobial and an alkanolamine are disclosed. The disclosed compositions may be free of quaternary ammonium compounds. The disclosed compositions have antimicrobial properties and rapid efficacy against yeast and bacteria.

Abstract: The present invention provides a compound, or a pharmaceutically acceptable salt thereof, of formula (I): wherein R1, R2, R3, R4, R5, R26, R27, y, R, M, W, L, V, T, Y, J, K and A are as described herein, therapeutic uses of said compounds, uses of said compounds as research chemicals, a pharmaceutical composition and combinations comprising said compounds, and methods for manufacturing the compounds of the invention.

Abstract: The present application pertains to pharmaceutical compositions for use in the treatment of cancer, whereby said pharmaceutical compositions are administered subcutaneously and wherein the pharmaceutical compositions of the invention comprise at least one conjugate that comprises an antibody which specifically binds to a cell surface antigen on a cancer cell and at least one amatoxin-linker payload. The present invention further pertains to methods of treating a patient afflicted with cancer using the pharmaceutical compositions of the invention.

Abstract: The present invention relates generally to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide, polymorphic forms thereof, methods for preparation and use thereof, pharmaceutical compositions thereof, and kits and articles of manufacture thereof.

Abstract: A method for determining a temperature of a fluid flowing through a pipe section includes: determining a temperature of the pipe section; obtaining a reference temperature at a distance from a surface of the pipe section; determining a heat transfer behaviour, in particular a thermal resistance, of a boundary layer of the fluid on an inner wall of the pipe section based on at least one material property and/or at least one value of a state variable of the fluid; and determining the temperature of the fluid based on the heat transfer behaviour of the boundary layer, a heat transfer behavior, in particular a thermal resistance, of the pipe section, the temperature of the pipe section, and the reference temperature.

Abstract: The present invention provides a compound, or a pharmaceutically acceptable salt thereof, of formula (I): wherein R1, R2, R3, R4, R5, R26, R27, y, R, M, W, L, V, T, Y, J, K and A are as described herein, therapeutic uses of said compounds, uses of said compounds as research chemicals, a pharmaceutical composition and combinations comprising said compounds, and methods for manufacturing the compounds of the invention.

Abstract: A method for testing a temperature measuring instrument is presented, where the instrument includes at least one sensor that changes its electrical resistance, and/or an electrical voltage that it produces, in response to being exposed to a change in temperature, and where the instrument is configured to be coupled to an object of interest. The method includes changing the temperature of at least one sensor by an amount that is detectable given the measurement resolution of the at least one sensor, by driving an electrical manipulation current through this sensor; obtaining one or measurement values from at least one sensor; and evaluating a state of the measuring instrument, a state of one or more of its sensors, and/or a state of a coupling to an object of interest, from the one or more measurement values.

Abstract: A method for controlling a robot includes the steps of: deciding whether there is a non-permanent object in a vicinity of the robot; if there is a non-permanent object, deciding whether the object qualifies for extended protection or not; and defining a safety zone around the object which the robot must not enter or in which a maximum allowed speed of the robot is less than outside the safety zone. The safety zone extends to a greater distance from the object if the object qualifies for extended protection than if it does not.

Abstract: A temperature measuring device for determining a medium temperature by a temperature of a measuring point on a surface enclosing the medium includes: at least one measuring sensor; at least one reference sensor; and a measured value processing device which is connected via a cable to the at least one measuring sensor and via a cable to the at least one reference sensor. The at least one measuring sensor and the at least one reference sensor are arranged along a main thermal connection path between the surface enclosing the medium and surroundings. The at least one measuring sensor is arranged close to the measuring point. A thermal resistance between a relevant measuring sensor and the at least one reference sensor is smaller than a thermal resistance between a relevant reference sensor and the surroundings.

Abstract: Automatic generation of documentation and software for an equipment or tool, together with an automatic synchronization between the corresponding documentation and software can be preformed with a tool model representation. The tool model can include a textual, graphical, symbolic, and program representation of the tool. Default components, derived components, and standard components can be added to the tool model.

Abstract: A device for measuring a strain of an object independently of temperature variations includes: at least one strain gauge that is attachable directly or indirectly to the object whose strain is to be measured; a first temperature sensor for measuring a temperature of the at least one strain gauge; read-out electronics for measuring a change of electrical resistance of the at least one strain gauge as a measured electrical resistance change, the read-out electronics including at least one fixed resistor whose value is relied upon when obtaining a value of the change of electrical resistance of the strain gauge as a result of the measurement, the read-out electronics being such that a temperature of the at least one fixed resistor is known and/or obtainable by measurement; and an evaluation unit for: correcting the measured electrical resistance change, and/or a strain of the strain gauge and/or the strain of the object.

Abstract: A method for testing a temperature measuring instrument is presented, where the instrument includes at least one sensor that changes its electrical resistance, and/or an electrical voltage that it produces, in response to being exposed to a change in temperature, and where the instrument is configured to be coupled to an object of interest. The method includes changing the temperature of at least one sensor by an amount that is detectable given the measurement resolution of the at least one sensor, by driving an electrical manipulation current through this sensor; obtaining one or measurement values from at least one sensor; and evaluating a state of the measuring instrument, a state of one or more of its sensors, and/or a state of a coupling to an object of interest, from the one or more measurement values.

Abstract: The present invention relates generally to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide, polymorphic forms thereof, methods for preparation and use thereof, pharmaceutical compositions thereof, and kits and articles of manufacture thereof.

Abstract: The present invention relates generally to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7, 8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide, polymorphic forms thereof, methods for preparation and use thereof, pharmaceutical compositions thereof, and kits and articles of manufacture thereof.

Abstract: A device for measuring a strain of an object independently of temperature variations includes: at least one strain gauge that is attachable directly or indirectly to the object whose strain is to be measured; a first temperature sensor for measuring a temperature of the at least one strain gauge; read-out electronics for measuring a change of electrical resistance of the at least one strain gauge as a measured electrical resistance change, the read-out electronics including at least one fixed resistor whose value is relied upon when obtaining a value of the change of electrical resistance of the strain gauge as a result of the measurement, the read-out electronics being such that a temperature of the at least one fixed resistor is known and/or obtainable by measurement; and an evaluation unit for: correcting the measured electrical resistance change, and/or a strain of the strain gauge and/or the strain of the object.

Abstract: A method for determining a temperature of a fluid flowing through a pipe section includes: determining a temperature of the pipe section; obtaining a reference temperature at a distance from a surface of the pipe section; determining a heat transfer behaviour, in particular a thermal resistance, of a boundary layer of the fluid on an inner wall of the pipe section based on at least one material property and/or at least one value of a state variable of the fluid; and determining the temperature of the fluid based on the heat transfer behaviour of the boundary layer, a heat transfer behavior, in particular a thermal resistance, of the pipe section, the temperature of the pipe section, and the reference temperature.

Abstract: A distance measuring system includes: at least one emitter, which emits a frequency-variable scanning signal; at least one receiver; and an analysis unit for computing a distance to an object reflecting the scanning signal on the basis of a difference between the frequencies of the emitted and the received scanning signal. The rate of change of the frequency of the scanning signal in a first operating mode of the distance measuring system has a first finite value. The rate of change of the frequency in a second operating mode has a second finite value. The analysis unit is configured to compute a first distance on the basis of a frequency difference ascertained in the first operating mode, to compute a second distance on the basis of a frequency difference ascertained in the second operating mode, and to evaluate the correspondence between first and second computed distance.

Abstract: A temperature measuring device for determining a medium temperature by a temperature of a measuring point on a surface enclosing the medium includes: at least one measuring sensor; at least one reference sensor; and a measured value processing device which is connected via a cable to the at least one measuring sensor and via a cable to the at least one reference sensor. The at least one measuring sensor and the at least one reference sensor are arranged along a main thermal connection path between the surface enclosing the medium and surroundings. The at least one measuring sensor is arranged close to the measuring point. A thermal resistance between a relevant measuring sensor and the at least one reference sensor is smaller than a thermal resistance between a relevant reference sensor and the surroundings.

Abstract: A method for controlling a robot includes the steps of: deciding whether there is a non-permanent object in a vicinity of the robot; if there is a non-permanent object, deciding whether the object qualifies for extended protection or not; and defining a safety zone around the object which the robot must not enter or in which a maximum allowed speed of the robot is less than outside the safety zone. The safety zone extends to a greater distance from the object if the object qualifies for extended protection than if it does not.

Abstract: A distance measuring system includes: at least one emitter, which emits a frequency-variable scanning signal; at least one receiver; and an analysis unit for computing a distance to an object reflecting the scanning signal on the basis of a difference between the frequencies of the emitted and the received scanning signal. The rate of change of the frequency of the scanning signal in a first operating mode of the distance measuring system has a first finite value. The rate of change of the frequency in a second operating mode has a second finite value. The analysis unit is configured to compute a first distance on the basis of a frequency difference ascertained in the first operating mode, to compute a second distance on the basis of a frequency difference ascertained in the second operating mode, and to evaluate the correspondence between first and second computed distance.