Patents by Inventor Andrea E. DeBarber

Andrea E. DeBarber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of diagnosing multidrug resistant tuberculosis
    Patent number: 7547519
    Abstract: The invention relates to the discovery that a putative gene of Mycobacterium tuberculosis with no previously identified function is responsible for the ability of the bacterium to activate thioamide drugs. Since M. tuberculosis has a low rate of synonymous mutations, all mutations in this gene, identified as Rv3854c and now termed “EtaA,” are expected to inhibit the ability of a bacterium with the mutation to activate a thioamide or thiocarbonyl drug. Thus, detecting a bacterium with a mutation in this gene indicates that the bacterium is resistant to treatment with thioamides.
    Type: Grant
    Filed: February 14, 2005
    Date of Patent: June 16, 2009
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Clifton E. Barry, III, Andrea E. DeBarber, Khisimuzi Mdluli, Linda-Gail Bekker
  • Methods of diagnosing multidrug resistant tuberculosis
    Patent number: 6905822
    Abstract: The invention relates to the discovery that a putative gene of Mycobacterium tuberculosis with no previously identified function is responsible for the ability of the bacterium to activate thioamide drugs. Since M. tuberculosis has a low rate of synonymous mutations, all mutations in this gene, identified as Rv3854c and now termed “EtaA,” are expected to inhibit the ability of a bacterium with the mutation to activate a thioamide or thiocarbonyl drug. Thus, detecting a bacterium with a mutation in this gene indicates that the bacterium is resistant to treatment with thioamides.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: June 14, 2005
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Clifton E. Barry, III, Andrea E. DeBarber, Khisimuzi Mdluli, Linda-Gail Bekker
  • Methods of diagnosing multidrug resistant tuberculosis
    Publication number: 20030013090
    Abstract: The invention relates to the discovery that a putative gene of Mycobacterium tuberculosis with no previously identified function is responsible for the ability of the bacterium to activate thioamide drugs. Since M. tuberculosis has a low rate of synonymous mutations, all mutations in this gene, identified as Rv3854c and now termed “EtaA,” are expected to inhibit the ability of a bacterium with the mutation to activate a thioamide or thiocarbonyl drug. Thus, detecting a bacterium with a mutation in this gene indicates that the bacterium is resistant to treatment with thioamides.
    Type: Application
    Filed: June 22, 2001
    Publication date: January 16, 2003
    Inventors: Clifton E. Barry, Andrea E. DeBarber, Khisimuzi Mdluli, Linda-Gail Bekker