Patents by Inventor Andrea E. Murmann

Andrea E. Murmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10934547
    Abstract: Disclosed are compositions and methods related to RNA interference (RNAi) and the use of RNAi active sequence for treating diseases and disorders. Particular disclosed are toxic RNAi active sequences such as siRNA and shRNA for killing cancer cells. The disclosed toxic RNAi active sequences typically include trinucleotide repeats and preferentially target the expression of multiple essential genes for cell survival and/or growth.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: March 2, 2021
    Assignee: Northwestern University
    Inventors: Marcus E. Peter, Andrea E. Murmann
  • Publication number: 20200299694
    Abstract: Disclosed are components and methods for producing toxic RNAs and/or extracellular vesicles comprising the toxic RNAs in cells that are resistant to the toxic RNAs, which toxic RNAs may include toxic shRNA/siRNA and/or toxic pre-miRNA/miRNA. The disclosed components may include engineered cells that can be utilized to express the toxic RNAs, in which the engineered cells do not express one or more genes that are required for processing the toxic RNAs for RNA interference (RNAi) and/or one or more genes that are required for executing RNAi. The toxic RNAs and/or extracellular vesicles comprising the toxic RNAs may be utilized in methods for treating diseases and disorders through RNAi.
    Type: Application
    Filed: March 19, 2020
    Publication date: September 24, 2020
    Applicant: Northwestern University
    Inventors: Marcus E. Peter, Andrea E. Murmann
  • Publication number: 20200299697
    Abstract: Disclosed are polynucleotides, compositions, and methods related to RNA interference (RNAi). Particular disclosed are toxic RNAi active seed sequences and methods of using toxic RNAi active sequences for killing cancer cells. The disclosed toxic RNAi active seed sequences preferentially target and inhibit the expression of multiple essential genes for cell survival and/or growth through a process called “death-induced by survival gene elimination” or “DISE.” The disclosed toxic RNAi active seed sequences may be referred to as “dual activity super toxic RNAi active dsRNAs” that include a toxic first strand and a toxic second strand that is complementary to the toxic first strand. As such, the disclosed dsRNAs may be expressed as shRNAs which are processed for RNA interference (RNAi) and either of the toxic first strand and the toxic second strand can function as a guide strand to initiate RNAi.
    Type: Application
    Filed: March 19, 2020
    Publication date: September 24, 2020
    Applicant: Northwestern University
    Inventors: Marcus E. Peter, Andrea E. Murmann
  • Publication number: 20180320187
    Abstract: Disclosed are polynucleotides, compositions, and methods related to RNA interference (RNAi). The disclosed polynucleotides, compositions, and methods may be utilized for treating diseases and disorders through RNAi. Particular disclosed are toxic RNAi active seed sequences and methods of using toxic RNAi active sequences for killing cancer cells. The disclosed toxic RNAi active seed sequences preferentially target and inhibit the expression of multiple essential genes for cell survival and/or growth through a process called “death-induced by survival gene elimination” or “DISE.
    Type: Application
    Filed: February 20, 2018
    Publication date: November 8, 2018
    Applicant: Northwestern University
    Inventors: Marcus E. Peter, William E. Putzbach, Andrea E. Murmann, Monal Patel, Quan Gao
  • Publication number: 20180251762
    Abstract: Disclosed are compositions and methods related to RNA interference (RNAi) and the use of RNAi active sequence for treating diseases and disorders. Particular disclosed are toxic RNAi active sequences such as siRNA and shRNA for killing cancer cells. The disclosed toxic RNAi active sequences typically include trinucleotide repeats and preferentially target the expression of multiple essential genes for cell survival and/or growth.
    Type: Application
    Filed: February 20, 2018
    Publication date: September 6, 2018
    Applicant: Northwestern University
    Inventors: Marcus E. Peter, Andrea E. Murmann