Patents by Inventor Andrea Forst

Andrea Forst has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GLYCOCONJUGATES OF RNA INTERFERENCE AGENTS
    Publication number: 20190264203
    Abstract: The present invention relates to agents, compositions and methods for inhibiting the expression of a target gene, comprising an RNAi agent bearing at least one galactosyl moiety. These are useful for delivering the gene expression inhibiting activity to cells, particularly hepatocytes, and more particularly in therapeutic applications.
    Type: Application
    Filed: October 5, 2018
    Publication date: August 29, 2019
    Inventors: Andrea FORST, Philipp HADWIGER, Hans-Peter VORNLOCHER
  • Glycoconjugates of RNA interference agents
    Patent number: 10131907
    Abstract: The present invention relates to agents, compositions and methods for inhibiting the expression of a target gene, comprising an RNAi agent bearing at least one galactosyl moiety. These are useful for delivering the gene expression inhibiting activity to cells, particularly hepatocytes, and more particularly in therapeutic applications.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: November 20, 2018
    Assignee: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Andrea Forst, Philipp Hadwiger, Hans-Peter Vornlocher
  • Glycoconjugates of RNA Interference Agents
    Publication number: 20150065558
    Abstract: The present invention relates to agents, compositions and methods for inhibiting the expression of a target gene, comprising an RNAi agent bearing at least one galactosyl moiety. These are useful for delivering the gene expression inhibiting activity to cells, particularly hepatocytes, and more particularly in therapeutic applications.
    Type: Application
    Filed: September 29, 2014
    Publication date: March 5, 2015
    Inventors: Andrea Forst, Philipp Hadwiger, Hans-Peter Vornlocher
  • Glycoconjugates of RNA interference agents
    Patent number: 8877917
    Abstract: The present invention relates to agents, compositions and methods for inhibiting the expression of a target gene, comprising an RNAi agent bearing at least one galactosyl moiety. These are useful for delivering the gene expression inhibiting activity to cells, particularly hepatocytes, and more particularly in therapeutic applications.
    Type: Grant
    Filed: April 23, 2008
    Date of Patent: November 4, 2014
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Andrea Forst, Philipp Hadwiger, Hans-Peter Vornlocher
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF GLUCOCORTICOID RECEPTOR (GCR) GENES
    Publication number: 20110020300
    Abstract: This invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a GCR gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a GCR gene using said pharmaceutical composition; and methods for inhibiting the expression of GCR in a cell.
    Type: Application
    Filed: May 14, 2010
    Publication date: January 27, 2011
    Applicant: GENENTECH, INC.
    Inventors: JACQUES BAILLY, AGNÈS BÉNARDEAU, BIRGIT BRAMLAGE, RAINER CONSTIEN, ANDREA FORST, MARKUS HOSSBACH, BRIGITTE SCHOTT
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF PTP1B GENES
    Publication number: 20100197773
    Abstract: This invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a PTP1B gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a PTP1B gene using said pharmaceutical composition; and methods for inhibiting the expression of PTP1B in a cell.
    Type: Application
    Filed: January 29, 2010
    Publication date: August 5, 2010
    Inventors: Birgit Bramlage, Rainer Constien, Andrea Forst, Markus Hossbach, John Reidhaar-Olson, Cristina Martha Rondinone, Hans-Peter Vornlocher
  • Glycoconjugates of RNA Interference Agents
    Publication number: 20090203135
    Abstract: The present invention relates to agents, compositions and methods for inhibiting the expression of a target gene, comprising an RNAi agent bearing at least one galactosyl moiety. These are useful for delivering the gene expression inhibiting activity to cells, particularly hepatocytes, and more particularly in therapeutic applications.
    Type: Application
    Filed: April 23, 2008
    Publication date: August 13, 2009
    Applicant: Alnylam Pharmaceuticals, Inc.
    Inventors: Andrea Forst, Philipp Hadwiger, Hans-Peter Vornlocher