Patents by Inventor Andrea Gail Neely

Andrea Gail Neely has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and materials for determining pain sensitivity and predicting and treating related disorders
    Patent number: 11085081
    Abstract: Methods of treating somatosensory disorders and modulating production of proinflammatory cytokines by administering to a subject an effective amount of a COMT modulator, ADRB2 modulator, ADRB3 modulator or combinations thereof are provided. Methods of predicting effective pharmacological therapies for a subject afflicted with a somatosensory disorder by determining a genotype of the subject with regard to a gene selected from the group consisting of COMT, ADRB2, ADRB3, and combinations thereof are further provided. Methods of determining pain responses or pain perception and predicting susceptibility of a subject to develop related disorders, such as somatosensory disorders and somatization, by determining a genotype of the subject with regard to a gene selected from the group consisting of COMT, ADRB2, ADRB3, and combinations thereof are further provided.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: August 10, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Luda B. Diatchenko, William Maixner, Gary D. Slade, Andrea Gail Neely
  • Formulations for controlled release of bupivacaine
    Patent number: 10292909
    Abstract: The disclosure provides biocompatible dental material that is moldable and biodegradable and provides sustained and/or controlled delivery of one or more local anesthetics within a dental cavity or space. Such dental material is customizable for the size and shape needed for a particular patient or particular application. The dental material may also provide customizable sustained and/or controlled delivery of one or more local anesthetics.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: May 21, 2019
    Assignees: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, RESEARCH TRIANGLE INSTITUTE
    Inventors: Leah Marie Johnson, Ginger Denison Rothrock, Sarah Dorothy Shepherd, Sandra Cordel O'Buckley, Andrea Gail Neely
  • METHODS AND MATERIALS FOR DETERMINING PAIN SENSITIVITY AND PREDICTING AND TREATING RELATED DISORDERS
    Publication number: 20190010548
    Abstract: Methods of treating somatosensory disorders and modulating production of proinflammatory cytokines by administering to a subject an effective amount of a COMT modulator, ADRB2 modulator, ADRB3 modulator or combinations thereof are provided. Methods of predicting effective pharmacological therapies for a subject afflicted with a somatosensory disorder by determining a genotype of the subject with regard to a gene selected from the group consisting of COMT, ADRB2, ADRB3, and combinations thereof are further provided. Methods of determining pain responses or pain perception and predicting susceptibility of a subject to develop related disorders, such as somatosensory disorders and somatization, by determining a genotype of the subject with regard to a gene selected from the group consisting of COMT, ADRB2, ADRB3, and combinations thereof are further provided.
    Type: Application
    Filed: May 1, 2018
    Publication date: January 10, 2019
    Inventors: Luda B. Diatchenko, William Maixner, Gary D. Slade, Andrea Gail Neely
  • FORMULATIONS FOR CONTROLLED RELEASE OF BUPIVACAINE
    Publication number: 20180325781
    Abstract: The disclosure provides biocompatible dental material that is moldable and biodegradable and provides sustained and/or controlled delivery of one or more local anesthetics within a dental cavity or space. Such dental material is customizable for the size and shape needed for a particular patient or particular application. The dental material may also provide customizable sustained and/or controlled delivery of one or more local anesthetics.
    Type: Application
    Filed: March 12, 2018
    Publication date: November 15, 2018
    Applicants: Research Triangle Institute, The University of North Carolina at Chapel Hill
    Inventors: Leah Marie Johnson, Ginger Denison Rothrock, Sarah Dorothy Shepherd, Sandra Cordel O'Buckley, Andrea Gail Neely
  • Biocompatible dental putty formulations for controlled release of bupivacaine
    Patent number: 9943466
    Abstract: The disclosure provides biocompatible dental material that is moldable and biodegradable and provides sustained and/or controlled delivery of one or more local anesthetics within a dental cavity or space. Such dental material is customizable for the size and shape needed for a particular patient or particular application. The dental material may also provide customizable sustained and/or controlled delivery of one or more local anesthetics.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: April 17, 2018
    Assignees: Research Triangle Institute, The University of North Carolina at Chapel Hill
    Inventors: Leah Marie Johnson, Ginger Denison Rothrock, Sarah Dorothy Shepherd, Sandra Cordel O'Buckley, Andrea Gail Neely
  • Methods and Materials for Determining Pain Sensitivity and Predicting and Treating Related Disorders
    Publication number: 20130244233
    Abstract: Methods of treating somatosensory disorders and modulating production of proinflammatory cytokines by administering to a subject an effective amount of a COMT modulator, ADRB2 modulator, ADRB3 modulator or combinations thereof are provided. Methods of predicting effective pharmacological therapies for a subject afflicted with a somatosensory disorder by determining a genotype of the subject with regard to a gene selected from the group consisting of COMT, ADRB2, ADRB3, and combinations thereof are further provided. Methods of determining pain responses or pain perception and predicting susceptibility of a subject to develop related disorders, such as somatosensory disorders and somatization, by determining a genotype of the subject with regard to a gene selected from the group consisting of COMT, ADRB2, ADRB3, and combinations thereof are further provided.
    Type: Application
    Filed: September 21, 2012
    Publication date: September 19, 2013
    Applicant: University of North Carolina at Chapel Hill
    Inventors: Luda B. Diatchenko, William Maixner, Gary D. Slade, Andrea Gail Neely