Abstract: The present invention provides a composition which comprises the following Thyroid Stimulating Hormone Receptor (TSHR) peptides: (i) all or part of the amino acid sequence KKKKYVSIDVTLQQLESHKKK (SEQ ID NO: 1), or a part thereof, or a sequence having at least 60% sequence identity to SEQ ID NO:1; and (ii) all or part of the amino acid sequence GLKMFPDLTKVYSTD (SEQ ID NO: 2), or a part thereof, or a sequence having at least 60% sequence identity to SEQ ID NO:2. The present invention also relates to the use of such a composition for the prevention or suppression of activating autoantibody formation in Graves' disease.

Abstract: The present invention provides a composition which comprises the following Thyroid Stimulating Hormone Recept or (TSHR) peptides: (i) all or part of the amino acid sequence KKKKYVSIDVTLQQLESHKKK (SEQ ID NO: 1), or a part thereof, or a sequence having at least 60% sequence identity to SEQ ID NO:1; and (ii) all or part of the amino acid sequence GLKMFPDLTKVYSTD (SEQ ID NO: 2), or a part thereof, or a sequence having at least 60% sequence identity to SEQ ID NO:2. The present invention also relates to the use of such a composition for the prevention or suppression of activating autoantibody formation in Graves' disease.

Abstract: This invention relates to a biopsy device consisting of an inner cannula (4) and an outer hollow tube (1), a handle (7) which may be removably attached to the outer hollow tube, a locking system to secure the inner cannula and/or the attenuator in the outer hollow tube, and characterized in that the tip of the outer hollow tube is ellipse shaped and extends beyond the inner cannula, the latter ending in a blunt edge. The blunted tip of the outer hollow tube together with the sharpened ending of the inner cannula determines the cutting edge of the device. In combination the distal ends of inner cannula and outer hollow tube determine the biopsy depth size and shape of the biopsy sample in a reproducible way. In one embodiment of the present invention, the length of the inner cannula can be controlled, allowing varying the aforementioned sample parameters as desired.

Abstract: This invention relates to a biopsy device consisting of an inner cannula (4) and an outer hollow tube (1), a handle (7) which may be removably attached to the outer hollow tube, a locking system to secure the inner cannula and/or the attenuator in the outer hollow tube, and characterized in that the tip of the outer hollow tube is ellipse shaped and extends beyond the inner cannula, the latter ending in a blunt edge. The blunted tip of the outer hollow tube together with the sharpened ending of the inner cannula determines the cutting edge of the device. In combination the distal ends of inner cannula and outer hollow tube determine the biopsy depth size and shape of the biopsy sample in a reproducible way. In one embodiment of the present invention, the length of the inner cannula can be controlled, allowing varying the aforementioned sample parameters as desired.