Abstract: A device for detecting moisture for an arrangement for monitoring an access to a patient for a system by which, via a flexible line, a liquid is fed to a patient and/or a liquid is fed out from the patient, and in particular for monitoring the vascular access in extra-corporeal blood treatment and particularly for monitoring a central venous catheter for acute dialysis includes at least a portion which can be deformed into a sleeve and placed around the circumference of the flexible line or of a connecting system. The portion in sleeve form has fastening means for fixing it in place in the position in which it surrounds the flexible line or the connecting system. The portion in sleeve form allows the device to be fastened quickly and securely to a flexible line or a connecting system.

Abstract: An actuation device (100), for a vehicle seat, has at least one locking mechanism (23). The actuation device (100) has an actuation handle (152), which is mounted on a housing (110), for unlocking the at least one locking mechanism (23). A connection device (200) couples the actuation device (100) to the at least one locking mechanism (23). The actuation handle (152) can be actuated in two different directions and the at least one locking mechanism (23) can be unlocked by actuating the actuation handle (152) in one direction and by actuating the actuation handle (152) in the other direction. As a result, an operating direction of the actuation handle (152) that is oriented in the movement direction of the vehicle seat is available for each movement direction of the vehicle seat. A vehicle seat (1) is also provided having at least one locking mechanism (23) and an actuation device (100).

Abstract: The invention relates to dihydropyridine compounds as inhibitors of the notch signalling pathway and/or inhibitors of secretion for the treatment of secretion-dependent disease, such as cancer or senescence-related ageing, in addition to pharmaceutical compositions thereof and methods of treatment.

Abstract: A device for detecting moisture for an arrangement for monitoring an access to a patient for a system by which, via a flexible line, a liquid is fed to a patient and/or a liquid is fed out from the patient, and in particular for monitoring the vascular access in extra-corporeal blood treatment and particularly for monitoring a central venous catheter for acute dialysis includes at least a portion which can be deformed into a sleeve and placed around the circumference of the flexible line or of a connecting system. The portion in sleeve form has fastening means for fixing it in place in the position in which it surrounds the flexible line or the connecting system. The portion in sleeve form allows the device to be fastened quickly and securely to a flexible line or a connecting system.

Abstract: A device for detecting moisture for an arrangement for monitoring an access to a patient for a system by which, via a flexible line, a liquid is fed to a patient and/or a liquid is fed out from the patient, and in particular for monitoring the vascular access in extra-corporeal blood treatment and particularly for monitoring a central venous catheter for acute dialysis includes at least a portion which can be deformed into a sleeve and placed around the circumference of the flexible line or of a connecting system. The portion in sleeve form has fastening means for fixing it in place in the position in which it surrounds the flexible line or the connecting system. The portion in sleeve form allows the device to be fastened quickly and securely to a flexible line or a connecting system.

Abstract: An actuation device (100), for a vehicle seat, has at least one locking mechanism (23). The actuation device (100) has an actuation handle (152), which is mounted on a housing (110), for unlocking the at least one locking mechanism (23). A connection device (200) couples the actuation device (100) to the at least one locking mechanism (23). The actuation handle (152) can be actuated in two different directions and the at least one locking mechanism (23) can be unlocked by actuating the actuation handle (152) in one direction and by actuating the actuation handle (152) in the other direction. As a result, an operating direction of the actuation handle (152) that is oriented in the movement direction of the vehicle seat is available for each movement direction of the vehicle seat. A vehicle seat (1) is also provided having at least one locking mechanism (23) and an actuation device (100).

Abstract: The invention relates to dihydropyridine compounds as inhibitors of the notch signalling pathway and/or inhibitors of secretion for the treatment of secretion-dependent disease, such as cancer or senescence-related ageing, in addition to pharmaceutical compositions thereof and methods of treatment.

Abstract: A device for detecting moisture for an arrangement for monitoring an access to a patient for a system by which, via a flexible line, a liquid is fed to a patient and/or a liquid is fed out from the patient, and in particular for monitoring the vascular access in extra-corporeal blood treatment and particularly for monitoring a central venous catheter for acute dialysis includes at least a portion which can be deformed into a sleeve and placed around the circumference of the flexible line or of a connecting system. The portion in sleeve form has fastening means for fixing it in place in the position in which it surrounds the flexible line or the connecting system. The portion in sleeve form allows the device to be fastened quickly and securely to a flexible line or a connecting system.

Abstract: Methods and apparatus, including computer program products, for a multi-purpose configuration model. A computer program product for defining a configuration model for a configurable product includes instructions operable to cause a programmable processor to receive a first input, and define, based on the first input, a first version of a first subcomponent to be used in the configuration model, the first version including information that describes the configurable product. The computer program product includes instructions to receive a second input, and define, based on the second input, a second version of the first subcomponent to be used in the configuration model, the second version including information that describes the configurable product. The computer program product designates one of the first or second versions to be an active version, and designates the other to be an inactive version.

Abstract: The virtual screening of a database of molecules is based on explicit three-dimensional molecular superpositions. The torsional flexibility of the database molecules is taken fully into account, and an arbitrary number of conformation-dependent molecular features may be considered. A fragmentation-reassembly approach is utilized, which allows for an efficient sampling of the conformational space. A fast clique-based pattern-matching algorithm generates alignments of pairs of adjacent molecular fragments on the (rigid) query molecule that are subsequently reassembled to complete database molecules. Using conventional molecular features (hydrogen bond donors and acceptors, charges, and hydrophobic groups), it is possible to rapidly produce accurate alignments of medium-sized drug-like molecules. Examples with a test database containing a diverse set of 1780 drug-like molecules (including all conformers) show that average query processing times of the order of 0.

Abstract: A countertop connecting fastener securing device, comprising: a first portion, wherein the first portion abuts a countertop section, wherein the first portion engages the countertop section to apply a force in a first direction; a second portion, wherein the second portion abuts the countertop section, wherein the second portion engages the countertop section to apply a force in a second direction, wherein the second direction is a direction that is different from the first direction; and a fastener connection, wherein the fastener connection couples the countertop connecting fastener securing device to a countertop connecting fastener.

Abstract: Methods and apparatus, including computer program products, for a multi-purpose configuration model. A computer program product, tangibly stored on a machine-readable medium, for defining a configuration model for a configurable product, includes instructions operable to cause a programmable processor to receive input. The product includes instructions to define, based on the input, a base component of the configuration model, the base component including information that describes the product. The product includes instructions to include, as a child object of the base component, a reused subcomponent that was previously defined, the reused subcomponent including information that describes the product.

Abstract: Methods and apparatus, including computer program products, for a multi-purpose configuration model. A computer program product for defining a configuration model for a configurable product includes instructions operable to cause a programmable processor to receive a first input, and define, based on the first input, a first version of a first subcomponent to be used in the configuration model, the first version including information that describes the product. The product includes instructions to receive a second input, and define, based on the second input, a second version of the first subcomponent to be used in the configuration model, the second version including information that describes the product. The product designates one of the first or second versions to be an active version, and designates the other to be an inactive version. The product also includes instructions to define a first component based at least in part on the active version.

Abstract: The virtual screening of a database of molecules is based on explicit three-dimensional molecular superpositions. The torsional flexibility of the database molecules is taken fully into account, and an arbitrary number of conformation-dependent molecular features may be considered. A fragmentation-reassembly approach is utilized, which allows for an efficient sampling of the conformational space. A fast clique-based pattern-matching algorithm generates alignments of pairs of adjacent molecular fragments on the (rigid) query molecule that are subsequently reassembled to complete database molecules. Using conventional molecular features (hydrogen bond donors and acceptors, charges, and hydrophobic groups), it is possible to rapidly produce accurate alignments of medium-sized drug-like molecules. Examples with a test database containing a diverse set of 1780 drug-like molecules (including all conformers) show that average query processing times of the order of 0.

Abstract: Methods and apparatus, including computer program products, for a multi-purpose configuration model. A computer program product, tangibly stored on a machine-readable medium, for defining a configuration model for a configurable product, includes instructions operable to cause a programmable processor to receive input. The product includes instructions to define, based on the input, a base component of the configuration model, the base component including information that describes the product. The product includes instructions to include, as a child object of the base component, a reused subcomponent that was previously defined, the reused subcomponent including information that describes the product.

Abstract: Methods and apparatus, including computer program products, for a multi-purpose configuration model. A computer program product, tangibly stored on a machine-readable medium, for defining a configuration model for a product, includes instructions operable to cause a programmable processor to receive input. The product includes instructions to define, based on the input, a base component of the configuration model, the base component including information that describes the product. The product includes instructions to define, based on the input, a first component of the configuration model, the first component including information that describes the product and that is associated with a first business process.

Abstract: A pigment paste for use in preparing aqueous paints includes a binder that includes at least one polyurethane acrylate resin, water as a solvent, and a pigment component that may be an organic pigment, an inorganic pigment, or carbon black. Preferably, the polyurethane acrylate is a product of a process comprising polymerizing one or more ethylenically unsaturated monomers in the presence of a polyurethane resin, which has a number-average molecular weight from about 200 to about 30,000, and which contains, on average, from about 0.05 to about 1.1 polymerizable double bonds per molecule. The reaction product is then converted into an aqueous dispersion, and mixed with the pigment and water to form the pigment paste. A preferred pigment paste contains from 10 to 35% of the polyurethane acrylate resin, from 10 to 65% water, and a percentage of the pigment component which varies, depending on the material selected.