Patents by Inventor Andrea L. Johnstone

Andrea L. Johnstone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMPROVED ASSAYS TO DETECT NUCLEOSOME MODIFICATIONS USING ANTIBODY-TARGETED ENZYME DIGESTION
    Publication number: 20230417742
    Abstract: This present invention relates to methods for improved assays to quantify the level of chromatin targets from biological samples. These assays can be used for the detection of global levels of epigenetic modifications (e.g., histone and DNA modifications), chromatin associated proteins, or chromatin associated ribonucleic acids (RNA). The invention further relates to assay kits that include the reagents needed to prepare biological samples and perform said improved chromatin assays.
    Type: Application
    Filed: November 2, 2021
    Publication date: December 28, 2023
    Inventors: Matthew R. Marunde, Nathan W. Hall, Zu-Wen Sun, Martis W. Cowles, Andrea L. Johnstone, Michael-Christopher Keogh, Ellen Weinzapfel, Kelsey Noll
  • QUANTIFICATION OF NUCLEOSOME MODIFICATIONS USING CHEMICALLY-DEFINED RECOMBINANT NUCLEOSOMES
    Publication number: 20210010058
    Abstract: The invention relates to the use of recombinant/semi-synthetic nucleosomes carrying histone and/or DNA modifications as a reference standard for quantification of covalently modified (on the histone proteins or wrapping DNA), variant, or mutant nucleosomes (collectively “modified nucleosomes” or “nucleosome modifications”) from a biological sample. The invention further relates to methods of using the assay to accurately quantify single or combinatorial nucleosome modifications as biomarkers of disease.
    Type: Application
    Filed: July 24, 2020
    Publication date: January 14, 2021
    Inventors: Martis William Cowles, Matthew F. Whelihan, Andrea L. Johnstone, Michael-Christopher Koegh, Zu-Wen Sun, Nathan W. Hall, Matthew R. Marunde
  • Quantification of nucleosome modifications using chemically-defined recombinant nucleosomes
    Patent number: 10787697
    Abstract: The invention relates to the use of recombinant/semi-synthetic nucleosomes carrying histone and/or DNA modifications as a reference standard for quantification of covalently modified (on the histone proteins or wrapping DNA), variant, or mutant nucleosomes (collectively “modified nucleosomes” or “nucleosome modifications”) from a biological sample. The invention further relates to methods of using the assay to accurately quantify single or combinatorial nucleosome modifications as biomarkers of disease.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: September 29, 2020
    Assignee: EpiCypher, Inc.
    Inventors: Martis William Cowles, Matthew F. Whelihan, Andrea L. Johnstone, Michael-Christopher Koegh, Zu-Wen Sun, Nathan W. Hall, Matthew R. Marunde
  • QUANTIFICATION OF NUCLEOSOME MODIFICATIONS USING CHEMICALLY-DEFINED RECOMBINANT NUCLEOSOMES
    Publication number: 20200071745
    Abstract: The invention relates to the use of recombinant/semi-synthetic nucleosomes carrying histone and/or DNA modifications as a reference standard for quantification of covalently modified (on the histone proteins or wrapping DNA), variant, or mutant nucleosomes (collectively “modified nucleosomes” or “nucleosome modifications”) from a biological sample. The invention further relates to methods of using the assay to accurately quantify single or combinatorial nucleosome modifications as biomarkers of disease.
    Type: Application
    Filed: November 8, 2019
    Publication date: March 5, 2020
    Inventors: Martis William Cowles, Matthew F. Whelihan, Andrea L. Johnstone, Michael-Christopher Koegh, Zu-Wen Sun, Nathan W. Hall, Matthew R. Marunde