Abstract: The disclosure relates to inhibitors of PCSK9 useful in the treatment of lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, or tautomer thereof, wherein R1, X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12, and X13 are described herein.

Abstract: A surgical drape for use during surgery on a patient includes a sheet configured for covering at least a portion of the patient during the surgery. The drape includes a first sheet portion having a size and configuration to overlie the patient during the medical procedure. A fenestration is defined in the first sheet portion at a location corresponding to the site of the medical procedure on the patient. A second sheet portion is attached to a lower surface of the first sheet portion and has a size and configuration so as to be draped from the first sheet portion and extend under the patient's buttocks while remaining attached to first sheet during the medical procedure.

Abstract: A surgical drape for use during surgery on a patient includes a sheet configured for covering at least a portion of the patient during the surgery. At least one pair of straps are configured on an underside of the sheet and extend in generally opposite directions laterally beyond sides of the sheet. The straps have a sufficient length so as to extend down below the support surface upon which the patient rests and engage with each other below the support surface, or with structure alongside the support surface, in order to restrain the patient in a desired position on the support surface.

Abstract: A drape, system, and method of using the system of identifying the location and/or size of an abnormality within a patient, the drape, system, and method each utilizing a x-ray detectable graduated element or marker. Utilization of the present invention is adapted to enhance the ability to detect the size and/or location of an abnormality in a patient thereby allowing a clinician to make better informed decisions concerning the care of the patient.

Abstract: A protective garment, such as a surgical gown, includes a body having a closed front, an open back, and sleeves. The closed front extends below a wearer's knees when the garment is donned. The closed front incorporates a section of elastomeric material that extends generally from an upper chest region of the garment to a location above a bottom edge of the gown that is also below the wearer's knees when the garment is donned. A border region of non-elastomeric material extends generally transversely across the closed front between the bottom edge of the garment and a bottom of the elastomeric material.

Abstract: A protective garment, such as a surgical gown, includes a front portion, a back portion, and sleeves. A skin wellness agent is deposited on an inner body-facing surface of at least one of the front portion, back portion, and sleeves, and may also be provided in the sleeve cuffs. The skin wellness agent is transferred to the wearer's skin through contact with the inner body-facing surface of the garment.