Patents by Inventor Andrea Loes

Andrea Loes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BARCODED INFLUENZA VIRUSES AND DEEP MUTATIONAL SCANNING LIBRARIES INCLUDING THE SAME
    Publication number: 20240044048
    Abstract: Methods to create barcoded influenza viruses without disrupting the function of the viral proteins and the proper packaging of the viral genome segments are described. The barcoded influenza viruses can be used within deep mutational scanning libraries to map influenza resistance mutations to therapeutic treatments. The libraries can also be used to predict influenza strains that may become resistant to therapeutic treatments and/or more easily evolve to infect new species. The libraries include features that allow efficient collection and assessment of informative data, obviating bottlenecks of previous approaches.
    Type: Application
    Filed: October 19, 2023
    Publication date: February 8, 2024
    Applicants: Fred Hutchinson Cancer Center, University of Washington
    Inventors: Jesse Bloom, Allison Greaney, Andrea Loes, Adam S. Dingens
  • Barcoded influenza viruses and deep mutational scanning libraries including the same
    Patent number: 11821111
    Abstract: Methods to create barcoded influenza viruses without disrupting the function of the viral proteins and the proper packaging of the viral genome segments are described. The barcoded influenza viruses can be used within deep mutational scanning libraries to map influenza resistance mutations to therapeutic treatments. The libraries can also be used to predict influenza strains that may become resistant to therapeutic treatments and/or more easily evolve to infect new species. The libraries include features that allow efficient collection and assessment of informative data, obviating bottlenecks of previous approaches.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: November 21, 2023
    Assignee: Fred Hutchinson Cancer Center
    Inventors: Jesse Bloom, Allison Greaney, Andrea Loes, Adam S. Dingens
  • BARCODED INFLUENZA VIRUSES AND DEEP MUTATIONAL SCANNING LIBRARIES INCLUDING THE SAME
    Publication number: 20210147832
    Abstract: Methods to create barcoded influenza viruses without disrupting the function of the viral proteins and the proper packaging of the viral genome segments are described. The barcoded influenza viruses can be used within deep mutational scanning libraries to map influenza resistance mutations to therapeutic treatments. The libraries can also be used to predict influenza strains that may become resistant to therapeutic treatments and/or more easily evolve to infect new species. The libraries include features that allow efficient collection and assessment of informative data, obviating bottlenecks of previous approaches.
    Type: Application
    Filed: November 13, 2020
    Publication date: May 20, 2021
    Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER
    Inventors: Jesse Bloom, Allison Greaney, Andrea Loes, Adam S. Dingens
  • Extraction buffer and method for isolating high-quality RNA from cells exposed to metal chloride solutions and clay mineral suspensions
    Patent number: 9200272
    Abstract: An RNA extraction buffer, an RNA extraction method, and an RNA extraction kit are described which enable functional, rapid, efficient, and high-quality RNA isolation from samples containing high concentrations of aqueous metal cations, clays, silica, or silicate minerals.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: December 1, 2015
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Andrea Loes, Shelley Haydel
  • EXTRACTION BUFFER AND METHOD FOR ISOLATING HIGH-QUALITY RNA FROM CELLS EXPOSED TO METAL CHLORIDE SOLUTIONS AND CLAY MINERAL SUSPENSIONS
    Publication number: 20140256929
    Abstract: An RNA extraction buffer, an RNA extraction method, and an RNA extraction kit are described which enable functional, rapid, efficient, and high-quality RNA isolation from samples containing high concentrations of aqueous metal cations, clays, silica, or silicate minerals
    Type: Application
    Filed: March 5, 2014
    Publication date: September 11, 2014
    Inventors: Andrea Loes, Shelley Haydel