Patents by Inventor Andrea M. A. Pfeifer
Andrea M. A. Pfeifer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7588781Abstract: A primary composition that includes at least one lipophilic bioactive compound and a whey protein in an amount effective to increase the bioavailability of the lipophilic bioactive compound, and methods of forming the same. Also, an oral composition that contains the primary composition in a foodstuff, in a food supplement, in a cosmetic preparation or in a pharmaceutical preparation, and methods of forming the same.Type: GrantFiled: October 27, 2006Date of Patent: September 15, 2009Assignee: Nestec S.A.Inventors: Karlheinz Bortlik, Francoise Saucy, Eliane Duruz, Myriam Richelle, Pierre Lambelet, Markus Baur, Andrea M. A. Pfeifer
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Publication number: 20090123542Abstract: The invention relates to a primary composition in which at least one lipophilic bioactive compound is mixed with a whey protein, present in an amount effective to increase the bioavailability of the lipophilic bioactive compound. The invention also relates to an oral composition that contains the primary composition in a foodstuff, in a food supplement, or in a pharmaceutical preparation, and to a cosmetic preparation that contains the primary composition. Methods for increasing the bioavailability of the lipophilic bioactive compound and providing increased photostability and oxidation resistance are also provided.Type: ApplicationFiled: January 14, 2009Publication date: May 14, 2009Applicant: NESTEC S.A.Inventors: Karlheinz Bortlik, Francoise Saucy, Eliane Duruz, Myriam Richelle, Pierre Lambelet, Markus Baur, Andrea M.A. Pfeifer
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Patent number: 6949381Abstract: The present invention relates to improved continuous (immortalized) cell lines, in particular keratinocytes and melanocytes derived from normal human skin tissue. The present invention also relates to novel serum-free media for isolating, producing and maintaining said improved continuous keratinocyte and melanocyte cell lines. The present invention also relates to methods for producing primary melanocytes and keratinocytes under serum-free conditions without any feeder cells.Type: GrantFiled: October 18, 2001Date of Patent: September 27, 2005Assignee: Nestec S.A.Inventors: Markus Baur, Catherine Mace, Armand Malnoe, Andrea M. A. Pfeifer, Marcelle Regnier
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Publication number: 20020107292Abstract: A primary composition that includes at least one lipophilic bioactive compound and a whey protein in an amount effective to increase the bioavailability of the lipophilic bioactive compound, and methods of forming the same. Also, an oral composition that contains the primary composition in a foodstuff, in a food supplement, in a cosmetic preparation or in a pharmaceutical preparation, and methods of forming the same.Type: ApplicationFiled: January 25, 2002Publication date: August 8, 2002Inventors: Karlheinz Bortlik, Francoise Saucy, Eliane Duruz, Myriam Richelle, Pierre Lambelet, Markus Baur, Andrea M.A. Pfeifer
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Patent number: 6423540Abstract: The present invention relates to improved continuous (immortalized) cell lines, in particular keratinocytes and melanocytes derived from normal human skin tissue. The present invention also relates to novel serum-free media for isolating, producing and maintaining said improved continuous keratinocyte and melanocyte cell lines. The present invention also relates to methods for producing primary melanocytes and keratinocytes under serum-free conditions without any feeder cells.Type: GrantFiled: June 19, 1998Date of Patent: July 23, 2002Assignee: Nestec S.A.Inventors: Markus Baur, Catherine Mace, Armand Malnoe, Andrea M. A. Pfeifer, Marcelle Regnier
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Patent number: 6399124Abstract: Frozen dessert based on an ice cream containing lactic acid bacteria, the said ice cream being coated over all or part of its surface with, and/or placed in, and/or between, an edible support, characterized in that the support is substantially free of lactic acid bacteria, and in that it comprises fermentable fibers specifically promoting the growth, in the intestinal tract, of the lactic acid bacteria contained initially in the ice cream. The invention also relates to the combined use of lactic acid bacteria and prebiotic fibers, for the preparation of a frozen composition in which the lactic acid bacteria and the fibers are not substantially in contact, for the treatment and/or the prevention of gastrointestinal disorders, for strengthening the human immune system, or for increasing the absorption of minerals.Type: GrantFiled: December 27, 1999Date of Patent: June 4, 2002Assignee: Nestec SAInventors: Corinne Lesens, Andrea M. Pfeifer, Florence Rochat
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Publication number: 20020042129Abstract: The present invention relates to improved continuous (immortalized) cell lines, in particular keratinocytes and melanocytes derived from normal human skin tissue. The present invention also relates to novel serum-free media for isolating, producing and maintaining said improved continuous keratinocyte and melanocyte cell lines. The present invention also relates to methods for producing primary melanocytes and keratinocytes under serum-free conditions without any feeder cells.Type: ApplicationFiled: October 18, 2001Publication date: April 11, 2002Applicant: NESTEC S.A.Inventors: Markus Baur, Catherine Mace, Armand Malnoe, Andrea M., A. Pfeifer, Marcelle Regnier
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Patent number: 6284537Abstract: Immortalized human cornea). epithelial cell line capable of becoming stratified, and capable of expressing (1) metabolic markers specific for non-immortalized human epithelial cells such as vimentin, cytokeratins, connections between the cells, cytochrome P450s, a glutathione-S-transferase, Cu/Zn-superoxide dismutase, glutathione peroxidase, aldehyde reductase and catalase; (2) metabolic differentiation markers specific for non-immortalized human cornea). epithelial cells such as the cytokeratin of 64 kfl, the glutathione-stransferase hGST 5.8, and the profile of cytokines and growth factors comprising the compounds TNF&agr;, IL-1&bgr;, IL-1&agr;, IL-6, IL-8, GM CSF-&bgr;, IL-ra, TGF-&bgr;1, TGF-&bgr;2, TGF&agr;, EGF, PDGF-&bgr;; (3) and markers specific for an inflammatory reaction such as collagenase I, the bradykinin, histamine and PAF receptors, and the system for transduction of an inflammatory signal by the phosphoinositides.Type: GrantFiled: December 23, 1997Date of Patent: September 4, 2001Assignee: Nestec S.A.Inventors: Elizabeth Offord Cavin, Andrea M. A. Pfeifer, Najam A. Sharif, Yvonne Tromvoukis
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Patent number: 6022568Abstract: Use of lactic acid bacteria in the preparation of a cream intended to coat all or part of an ice cream. The ice cream is an expanded and chilled cream, coated over all or part of its external surface with a non-expanded coating containing 10.sup.3 to 10.sup.9 cfu/g of lactic acid bacteria. Preferably, the expanded cream includes more than 10.sup.6 cfu/g of lactic acid bacteria, the ratio (e/g) between the number of lactic acid bacteria in the coating (e) and the number of lactic acid bacteria in the expanded cream (g) being greater than 1. The coating may include 1% to 70% of a milk fermented by lactic acid bacteria, 0.5% to 5% of animal or vegetable proteins, a lactic fat content of from 2% to 20% and preferably the strain Lactobacillus acidophilus CNCM I-1225.Type: GrantFiled: May 21, 1999Date of Patent: February 8, 2000Assignee: Nestec, S.A.Inventors: Corinne Lesens, Christian Dufort, Andrea M. A. Pfeifer, Florence Rochat
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Patent number: 5660986Abstract: Non-tumorigenic, stable, human bronchial and liver epithelial cell lines are provided wherein the cell lines are capable of expressing human cytochrome P450 genes which have been inserted into the cell lines. Also provided are methods and kits for identifying potential mutagens, cytotoxins, carcinogens, chemotherapeutic and chemo-preventive agents utilizing these cell lines.Type: GrantFiled: June 5, 1995Date of Patent: August 26, 1997Inventors: Curtis C. Harris, Harry V. Gelboin, Frank J. Gonzalez, Katharine C. Mace, Andrea M. A. Pfeifer
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Patent number: 5529920Abstract: The present invention relates to long term multiplication and permanent establishment of a cell line of human liver epithelial cells(hepatocytes). The human liver epithelial cell line is capable of mitotically proliferating and continuously growing in vitro under suitable environmental conditions in suitable culture media. A method of producing an immortalized human liver epithelial cell line is also disclosed. The invention also relates to serum-free cell medium developed to support long term multiplication and permanent establishment of a cell line of human liver epithelial cells.Type: GrantFiled: May 1, 1992Date of Patent: June 25, 1996Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Katharine H. Cole, John F. Lechner, Roger Reddel, Curtis C. Harris, Andrea M. Pfeifer
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Patent number: 5506131Abstract: Non-tumorigenic, stable, human bronchial and liver epithelial cell lines are provided wherein the cell lines are capable of expressing human cytochrome P450 genes which have been inserted into the cell lines. Also provided are methods and kits for identifying potential mutagens, cytotoxins, carcinogens, chemotherapeutic and chemo-preventive agents utilizing these cell lines.Type: GrantFiled: May 19, 1993Date of Patent: April 9, 1996Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Curtis C. Harris, Harry V. Gelboin, Frank J. Gonzalez, Katharine C. Mace, Andrea M. A. Pfeifer
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Patent number: 5356806Abstract: Non-tumorigenic, human bronchial epithelial cell lines are provided wherein the cell lines are capable of expressing cytochrome P450 genes which have been inserted into the cell lines. Also provided are methods and kits for identifying potential mutagens, cytotoxins, carcinogens, and chemotherapeutic agents utilizing these cell lines.Type: GrantFiled: April 13, 1992Date of Patent: October 18, 1994Assignees: The United States of America as represented by the Department of Health and Human Services, Nestec, S.A.Inventors: Curtis C. Harris, Harry V. Gelboin, Frank J. Gonzalez, Andrea M. A. Pfeifer