Abstract: The present disclosure relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals. In some embodiments, the present disclosure provides a compound of Formula (A): or a tautomer thereof or a pharmaceutically acceptable salt of the compound or tautomer.

Abstract: The present disclosure relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals. In some embodiments, the present disclosure provides a compound of Formula (A) or a tautomer thereof or a pharmaceutically acceptable salt of the compound or tautomer.

Abstract: The present disclosure relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals. In some embodiments, the present disclosure provides a compound of Formula (I): or a tautomer thereof or a pharmaceutically acceptable salt of the compound or tautomer.

Abstract: The present disclosure relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals. In some embodiments, the present disclosure provides a compound of Formula (I): or a tautomer thereof or a pharmaceutically acceptable salt of the compound or tautomer.

Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals.

Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals.

Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals.

Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals.

Abstract: The invention relates to a method for monitoring the wear of a pair of hand pliers with which crimping elements can be pressed onto a workpiece and a particular degree of crimping mp, to be obtained by actuating the pliers, set using a presetting device. An arrangement is described for carrying out this method, as is a pair of hand pliers implementing the method. The method includes: counting each actuation of the hand pliers and linking to the degree of crimping mp that has been set; reading out a wear prognosis value Vt, from a memory, for the degree of crimping that has been set; determining a total wear value V by adding up the wear prognosis value Vt for each actuation; verifying whether the total wear value reaches or exceeds a defined threshold value VG, and issuing a calibration request if necessary.

Abstract: The present invention concerns a lamp with jointed rigid arms forming, in the folded position, a spiral shape, that can be a circular spiral or a polygonal spiral: see FIG. 1A, 2, 12, 13, 14, 15, 16. The arms are joined one another by means of joints, see FIG. 3, housed and locked inside the arms, and that consist of cylindrical hinges provided with brakes having an adjustable braking moment, see FIGS. 3, 4 and 5. This allows to turn at will the arms one another and to keep them still in the wanted position. The joints have a pass through hole inside, see FIGS. 3, 7 and 8, to permit the passing of the electric wires or of the optical fibres.

Abstract: Method for carrying out a transaction on a system that includes at least one central processing platform, at least issuer server and at least one acquirer server, wherein the central processing platform includes a routing engine coupled by a communication connection to the issuer server and the acquirer server, and the method includes the steps of receiving a transaction inquiry at the acquirer server or the issuer server, routing of the inquiry from the acquirer server or from the issuer server to the central processor platform, and operating the central processor platform, in order to implement the transaction.

Abstract: The present invention provides a method for determining pathogen sensitivity to varying levels of reduction of a gene product using an expression vector system having a promoter that is essentially off in vitro and turns on selectively during the infection process in vivo. Genes and gene products identified by this method as essential to growth of infection of a selected pathogen are also provided. In addition, therapeutic compositions designed to target genes identified by this method are provided.

Abstract: The present invention provides a method for determining pathogen sensitivity to varying levels of reduction of a gene product using an expression vector system having a promoter that is essentially off in vitro and turns on selectively during the infection process in vivo. Genes and gene products identified by this method as essential to growth of infection of a selected pathogen are also provided. In addition, therapeutic compositions designed to target genes identified by this method are provided.

Abstract: The invention provides tktA polypeptides and polynucleotides encoding tktA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tktA polypeptides and polynucleotides to screen for antibacterial compounds and for the detection of Streptococcus pneumoniae.

Abstract: The invention provides Histidine kinase polypeptides and polynucleotides encoding Histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Histidine kinase polypeptides to screen for antibacterial compounds.