Abstract: A prosthetic talus comprising: a base having a top surface and a bottom surface; and an articulating component having a top surface and a bottom surface, wherein the bottom surface of the articulating component is removably coupled to the top surface of the base, wherein the bottom surface of the articulating component includes a protrusion, and wherein the top surface of the base includes a recess configured to receive the protrusion to thereby removably couple the articulating component to the base, wherein the articulating component includes a sidewall positioned between the top surface and the bottom surface, and wherein the sidewall includes a plurality of holes.

Abstract: The present disclosure provides a prosthetic ankle including a talar component having a top surface and a bottom surface. The bottom surface is configured to be positioned adjacent to a talus. The top surface includes a trochlear groove extending from a posterior side of the talar component to an anterior side of the talar component. The trochlear groove includes a first portion adjacent the posterior side of the talar component and a second portion adjacent the anterior side of the talar component.

Abstract: Devices and methods for extracting and concentrating therapeutically active factors from mammalian fluids and tissues are described herein.

Abstract: Systems and methods for preparing enriched biological samples, and methods of use thereof are described herein. The systems can include a containment device connected to a first insert to collect tissue fragments in the containment device or to a second insert to incubate tissue fragments with a blood sample in the containment device. The methods can include methods for preparing a cytokine or growth factor-enriched biological sample, such as IL-1 Ra-enriched serum, methods of treating inflammation, inflammatory joint, or rheumatoid arthritis, and methods of preventing inflammation of a joint following arthroscopic surgery.

Abstract: Methods of stimulating collagen production, including stimulation of chondrocyte production, at the site of a defect. Methods include administering to the site of a defect at least two proteins from the group IL-1ra, sTNF-RI, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-?1, and sIL-1RII.

Abstract: Devices and methods for collecting tissue fragments of variable sizes from a surgical site are described herein. The devices can include at least two filters having a different pore size for the collection and sorting of tissue fragments by size.

Abstract: Devices and methods for extracting and concentrating therapeutically active factors from mammalian fluids and tissues are described herein.

Abstract: Devices and methods for collecting tissue fragments of variable sizes from a surgical site are described herein. The devices can include at least two filters having a different pore size for the collection and sorting of tissue fragments by size.

Abstract: Methods and systems disclosed herein provide systems and methods for maintaining sterile conditions inside of a biological-fluid container during an entire process of delivery, incubation, centrifugation, and extraction of fluid. The methods and systems also provide systems and methods for localized extraction of a portion of a biological fluid.

Abstract: Methods and systems disclosed herein provide systems and methods for maintaining sterile conditions inside of a biological-fluid container during an entire process of delivery, incubation, centrifugation, and extraction of fluid. The methods and systems also provide systems and methods for localized extraction of a portion of a biological fluid.

Abstract: Devices and methods for collecting tissue fragments of variable sizes from a surgical site are described herein. The devices can include at least two filters having a different pore size for the collection and sorting of tissue fragments by size.

Abstract: Devices and methods for extracting and concentrating therapeutically active factors from mammalian fluids and tissues are described herein.

Abstract: Methods and systems disclosed herein provide systems and methods for maintaining sterile conditions inside of a biological-fluid container during an entire process of delivery, incubation, centrifugation, and extraction of fluid. The methods and systems also provide systems and methods for localized extraction of a portion of a biological fluid.

Abstract: Methods and systems disclosed herein provide systems and methods for maintaining sterile conditions inside of a biological-fluid container during an entire process of delivery, incubation, centrifugation, and extraction of fluid. The methods and systems also provide systems and methods for localized extraction of a portion of a biological fluid.

Abstract: Methods of stimulating collagen production, including stimulation of chondrocyte production, at the site of a defect. Methods include administering to the site of a defect at least two proteins from the group IL-1ra, sTNF-RI, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-?1, and sIL-1RII.

Abstract: Methods of stimulating collagen production, including stimulation of chondrocyte production, at the site of a defect. Methods include administering to the site of a defect at least two proteins from the group IL-1ra, sTNF-RI, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-?1, and sIL-1RII.

Abstract: Methods and systems disclosed herein provide systems and methods for maintaining sterile conditions inside of a biological-fluid container during an entire process of delivery, incubation, centrifugation, and extraction of fluid. The methods and systems also provide systems and methods for localized extraction of a portion of a biological fluid.

Abstract: Methods of stimulating collagen production, including stimulation of chondrocyte production, at the site of a defect. Methods include administering to the site of a defect at least two proteins from the group IL-1ra, sTNF-RI, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-?1, and sIL-1RII.

Abstract: Methods of stimulating collagen production, including stimulation of chondrocyte production, at the site of a defect. Methods include administering to the site of a defect at least two proteins from the group IL-1ra, sTNF-RI, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-?1, and sIL-1RII.