Patents by Inventor Andrea McCart

Andrea McCart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RECOMBINANT ONCOLYTIC VIRUSES FOR CANCER THERAPY
    Publication number: 20200046784
    Abstract: The disclosure provides a recombinant oncolytic poxvirus including vaccinia virus comprising one or more inactivated immunomodulatory gene selected from NIL, K1L, K3L, A46R, and/or A52R, optionally further comprising inactivated TK and/or VGF genes. The disclosure also provides methods and for the use of these recombinant oncolytic poxvirus in oncolytic virotherapy. Also provided in the disclosure are vector constructs for generating recombinant oncolytic poxviruses including for example vaccinia viruses that have one or more inactivated immunomodulatory genes.
    Type: Application
    Filed: October 2, 2017
    Publication date: February 13, 2020
    Inventors: Judith Andrea MCCART, David Francis STOJDL, Tiffany Yun-Yee HO
  • COMPOSITIONS AND METHODS FOR CANCER TREATMENT
    Publication number: 20160250309
    Abstract: Compositions and methods for delivering tumor associated antigens and immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably integrating lentiviral delivery systems. The methods are useful for therapeutically and prophylactically treating cancer such as colon cancer.
    Type: Application
    Filed: January 26, 2016
    Publication date: September 1, 2016
    Inventors: Jeffrey A. Medin, Andrea McCart, Severine Loisel
  • COMPOSITIONS AND METHODS FOR CANCER TREATMENT
    Publication number: 20140193449
    Abstract: Compositions and methods for delivering tumor associated antigens and immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably integrating lentiviral delivery systems. The methods are useful for therapeutically and prophylactically treating cancer such as colon cancer.
    Type: Application
    Filed: January 8, 2014
    Publication date: July 10, 2014
    Applicant: University Health Network
    Inventors: Jeffrey A. Medin, Andrea McCart, Severine Loisel-Meyer
  • Vaccinia virus expression vector for selective replication in a tumor cell and introduction of exogenous nucleotide sequence into a tumor cell
    Patent number: 8506947
    Abstract: A composition of matter comprising a vaccinia virus expression vector with a negative thymidine kinase phenotype and a negative vaccinia virus growth factor phenotype.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: August 13, 2013
    Assignee: The United States of America as Represented by the Secretary of the Department of Health and Human Services
    Inventors: J. Andrea McCart, David L. Bartlett, Bernard Moss
  • Compositions and Methods for Cancer Treatment
    Publication number: 20110027310
    Abstract: Compositions and methods for delivering immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably integrating lentiviral delivery systems. The methods are useful for therapeutically and prophylactically treating cancer such as colon cancer and prostate cancer.
    Type: Application
    Filed: May 5, 2008
    Publication date: February 3, 2011
    Inventors: Jeffrey A. Medin, Andrea McCart, Severine Loisel-Meyer
  • Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
    Patent number: 7208313
    Abstract: A composition of matter comprising a vaccinia virus expression vector with a negative thymidine kinase phenotype and a negative vaccinia virus growth factor phenotype.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: April 24, 2007
    Assignee: United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: J. Andrea McCart, David L. Bartlett, Bernard Moss
  • Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
    Publication number: 20030031681
    Abstract: A composition of matter comprising a vaccinia virus expression vector with a negative thymidine kinase phenotype and a negative vaccinia virus growth factor phenotype.
    Type: Application
    Filed: November 13, 2001
    Publication date: February 13, 2003
    Inventors: J. Andrea McCart, David L. Bartlett, Bernard Moss