Abstract: Devices, systems, and methods herein relate to non-invasive patient monitoring for infection detection and infection resolution. These systems and methods may receive and measure patient biosignals to estimate an infection level of a patient. In some embodiments, a method may include the steps of receiving physiological data of a patient. An infection measure may be estimated based on the physiological data. An infection state of the patient may be detected based at least in part on the estimated infection measure.