Abstract: Novel inhibitors of cathepsin S, K, B, and L, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.

Abstract: In a method to convert color-describing input print data suitable for graphical output with aid of an output apparatus into color-describing output print data, color proportions, defined by the input print data, of at least one region to be inked with at least two color separations, are determined, and a color space value to be generated with aid of the color separations is determined. An association rule is determined to convert the input print data into the output print data while retaining the color space value. A total areal coverage of areal coverages defined by the output print data of the color separations to generate the color space value is reduced relative to areal coverages of the color separations defined by the input print data. The input print data is converted into the output print data with aid of the determined association rule.

Abstract: In a method or device for conversion of source image data into target image data, source image data are processed to generate a source image in at least one first color. The target image data is generated for generation of a target image in at least one second color differing from the first color. With the source of image data for each image element of the target image, the brightness value of an inking of the source image in a region of the image element is determined. Dependent on the determined brightness values, the target image data are generated via which each image element in the target image generated in the second color has a substantially same brightness value as the brightness value determined for the respective image element in a source image.

Abstract: The invention relates to a sealing mass with low density and improved tensile strength on the basis of sulfur-containing polymers such as on the basis of polysulfide, polyether or/and polytioether that has a density of not more than 1.3 g/cm3 according to ISO 2781 and a tensile strength of at least 1.9 N/mm2 according to ISO 37 after curing. The invention further relates to a ground mass based on sulfur-containing polymers for producing a sealing mass that comprises at least one long-chain linear polymer and at least one short-chain branched polymer having a content in trifunctional molecules, or/and at least one multifunctional cross-linker with a number of functional groups n?3.

Abstract: In order to be able to print a prescribed target color with a printing system, the color data of the target color and of the mixed color compounded with parts of the primary colors are compared, and the addition of the parts is varied until adequate similarity has been achieved between the color data of the target color and of the mixed color. In a further step, the mixed color is printed out, the color data of the printed mixed color are identified, and these are compared to those of the target color. Given inadequate similarity, additional parts of the primary colors are added to the mixed color until the respectively printed mixed color has its color data adequately coinciding with the color data of the target color. The mixed color corresponding to the target color is produced from the identified parts and additional parts of the primary colors.

Abstract: In order to adapt the colors of a second printing system to those of a first printing system, the primary colors of the two printing systems that deviate from one another are first identified. Subsequently, the deviating primary colors of the second printing system are adapted to those of the first printing system in that parts of other primary colors are mixed to the deviating primary color to form a mixed primary color until an adequate similarity to the corresponding primary color of the first printing system has been achieved.

Abstract: The invention relates to nucleic acid molecules encoding (poly)peptides having chemotaxis inhibiting (poly)peptides CHIPS activity, to recombinant vectors harboring such molecules, and the host cells carrying the vectors. The invention further relates to methods for preparing recombinant (poly)peptides having CHIPS activity and to the use of such recombinant (poly)peptides having CHIPS activity for diagnosis, prophylaxis and treatment, such as the treatment of inflammation reactions and HIV. In addition, the invention provides therapeutic and diagnostic compositions comprising as the active ingredient the (poly)peptide having CHIPS activity.

Abstract: The present invention describes a process for preparing a toner mixture comprising mixing a first toner with at least one further toner wherein the first toner has an acid value of from 0.1 to 30 mgKOH/g and comprises at least one binder resin and at least one coloring agent wherein said binder comprises as the main component a polyester resin and wherein the further toners comprise at least a binder resin and optionally at least one coloring agent. It also describes a developer composition comprising said toner mixture and optionally a carrier. The new toner mixture does not show any de-mixing phenomenon during repeated use.

Abstract: The invention relates to a process for coating a substrate with a sealant, in particular for joining or gluing parts or/and sealing off or filling hollow and intermediate spaces, which is characterized in that the not yet cured sealant comprises a latent catalyst which is released or/and formed in the active form under external action of energy and as a result initiates or/and accelerates the reaction between the base polymer and hardener for the curing.

Abstract: The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.

Abstract: The invention relates to a sealing mass with low density and improved tensile strength on the basis of sulfur-containing polymers such as on the basis of polysulfide, polyether or/and polytioether that has a density of not more than 1.3 g/cm3 according to ISO 2781 and a tensile strength of at least 1.9 N/mm2 according to ISO 37 after curing. The invention further relates to a ground mass based on sulfur-containing polymers for producing a sealing mass that comprises at least one long-chain linear polymer and at least one short-chain branched polymer having a content in trifunctional molecules, or/and at least one multifunctional cross-linker with a number of functional groups n≧3.

Abstract: A method for control of a gear step change in a vehicle having a dual clutch transmission (2) actuatable by a prime mover (4), several gear steps in which a first dividing gear (6) and a second dividing gear (10) can be operatively coupled with the prime mover (4), respectively, by a first clutch (8) and a second clutch (12) and both dividing gears (6, 10) have a common output (14) wherein each dividing gear (6, 10) preferably has several ratio steps and at least two consecutive gear steps of the dual clutch transmission (2) are not associated with the same dividing gear (6, 10). It is proposed that upon a demand for a double downshift, a gear step change occurs within the same dividing gear (6) without the other dividing gear (10) transmitting during the gear step change a torque from the prime mover (4) to the output, and that the torque delivered by the prime mover (4) during the gear step change is essentially used for the acceleration of rotary masses on the side of the prime mover.

Abstract: The present invention relates to a universal carrier for a two-component developer comprising a carrier base component and a carrier preaging component that comprises at least one toner resin and/or at least one surface additive, the carrier base component being present in the form of at least partially abraded particles and part of the carrier preaging component adhering to the outside surfaces of the particles of the carrier base component and part of the carrier preaging component being contained in surface depressions of the particles of the carrier base component. Compositions comprising the inventive universal carrier and usual toners yield a two-component developer that requires no toner-specific preaging but can be used directly in the printer.

Abstract: The invention relates to nucleic acid molecules encoding (poly)peptides having CHIPS activity, to recombinant vectors harboring such molecules, and the host cells carrying the vectors. The invention further relates to methods for preparing recombinant (poly)peptides having CHIPS activity and to the use of such recombinant (poly)peptides having CHIPS activity for diagnosis, prophylaxis and treatment, such as the treatment of inflammation reactions and HIV. In addition the invention provides therapeutic and diagnostic compositions comprising as the active ingredient the (poly)peptide having CHIPS activity.

Abstract: The invention relates to relates a steering system and to a steering method which counteract a mistake that inexperienced drivers frequently make. The invention relates to a system (12, 14, 6) for determining the transversal slip that occurs at the steerable wheels (2). A electronic control system (6) is used to determine an upper threshold value for said transversal slip. If the transversal slip exceeds said threshold value, an augmentation of the angle of lock is counteracted by either limiting said angle of lock and/or outputting a warning signal that can be perceived by the driver.

Abstract: A method for control of a gear step change in a vehicle having a dual clutch transmission (2) actuatable by a prime mover (4), several gear steps in which a first dividing gear (6) and a second dividing gear (10) can be operatively coupled with the prime mover (4), respectively, by a first clutch (8) and a second clutch (12) and both dividing gears (6, 10) have a common output (14) wherein each dividing gear (6, 10) preferably has several ratio steps and at least two consecutive gear steps of the dual clutch transmission (2) are not associated with the same dividing gear (6, 10). It is proposed that upon a demand for a double downshift, a gear step change occurs within the same dividing gear (6) without the other dividing gear (10) transmitting during the gear step change a torque from the prime mover (4) to the output, and that the torque delivered by the prime mover (4) during the gear step change is essentially used for the acceleration of rotary masses on the side of the prime mover.

Abstract: In order to be able to print a prescribed target color with a printing system, the color data of the target color and of the mixed color compounded with parts of the primary colors are compared, and the addition of the parts is varied until adequate similarity has been achieved between the color data of the target color and of the mixed color. In a further step, the mixed color is printed out, the color data of the printed mixed color are identified, and these are compared to those of the target color. Given inadequate similarity, additional parts of the primary colors are added to the mixed color until the respectively printed mixed has its color data adequately coinciding with those of the target color. The mixed color corresponding to the target color is produced from the identified parts and additional parts of the primary colors.

Abstract: In order to adapt the colors of a second printing system to those of a first printing system, the primary colors of the two printing systems that deviate from one another are first identified. Subsequently, the deviating primary colors of the second printing system are adapted to those of the first printing system in that parts of other primary colors are mixed to the deviating primary color to form a mixed primary color until an adequate similarity to the corresponding primary color of the first printing system has been achieved.

Abstract: A device for monitoring the travel of yarn-like structures at a textile machine comprises a cantilever member vibrating in a flexural mode when excited by a traveling yarn which is in contact with the upper or free end of said cantilever member. The lower end thereof is rigidly connected or integral with a rigid base member having the effect of a seismic mass when exposed to shock or vibration. Moreover, soft elastic material is provided to prevent transfer of such shock or vibration from the textile machine to the cantilever member. A mechano-electrical transducer element, e.g., a piezoelectric element, is comprised by or coupled with the cantilever member for generating an electrical yarn travel signal. A casing may be provided for protecting said cantilever member against ambient noise and other undesired actions acting from outside the casing.