Abstract: The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.

Abstract: The invention relates to a device comprising: an expansion machine for generating mechanical energy by expanding vapor of a working medium; a generator connected to a shaft of the expansion machine and used for generating electric energy from mechanical energy of the expansion machine; wherein the expansion machine and the generator form a structural unit with an exhaust vapor chamber between the expansion machine and the generator, and wherein, when the expansion machine is in operation, working medium expanded into the exhaust vapor chamber contacts the generator; and means for feeding, in particular injecting, a liquid working medium into the exhaust vapor chamber. The invention also relates to an ORC device comprising the device according to the present invention and to a method for operating the device according to the present invention.

Abstract: The invention relates to a method for lubricating an expansion machine (30) in a thermodynamic cycle device, wherein the thermodynamic cycle device comprises the expansion machine, a feed pump (50), a lubricant separator (10) and a working medium containing a lubricant, and wherein the method comprises the following steps: The working medium is subjected to pressure by means of the feed pump. The pressurised working medium is delivered by the feed pump to the lubricant separator. At least part of the lubricant is separated from the working medium by means of the lubricant separator. At least part of the separated lubricant is delivered by the lubricant separator to the expansion machine.

Abstract: The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.

Abstract: The invention relates to a thermodynamic cycle apparatus, comprising: a working medium; an evaporator for evaporating the working medium; an expansion machine for generating mechanical energy while expanding the evaporated working medium; a condenser for condensing the working medium, and a pump for pumping the condensed working medium to the condenser, wherein the geometrical arrangement of the evaporator is selected such that, prior to starting the pump, the condensed working medium can flow from the condenser to the evaporator by force of gravity and the working medium can circulate in a closed circuit via the evaporator and the condenser, whereby in particular a predetermined head height of the liquid working medium can be provided at the pump.

Abstract: The present invention relates to a method for controlling a pump, in particular a centrifugal pump, during pumping of a liquid, comprising the following steps: fixing a setpoint value of a flow rate of the pump; measuring an inlet pressure of the liquid upstream of the pump and an outlet pressure of the liquid downstream of the pump; determining a setpoint value of a rotational speed of the pump from a performance map of the pump, wherein the fixed setpoint value of the flow rate and a difference between the outlet pressure and the inlet pressure are incorporated into the performance map as input values; and setting the rotational speed of the pump to the setpoint value of the rotational speed. Furthermore, the invention relates to a corresponding device for controlling a pump.

Abstract: The invention relates to a thermodynamic circuit process device comprising a working medium having a lubricant additive; an expansion machine (5) for converting enthalpy in the working medium into mechanical energy; a multi-stage pressure-increasing apparatus (1) for the step-by-step pressurisation of the working medium; a means (4) for branching a part of the working medium between two stages of the multi-stage pressure-increasing apparatus (1); and a means (4) for feeding the branched off part of the working medium to one or a plurality of bearing points of the expansion machine. The invention further relates to a corresponding method for lubricating an expansion machine in a thermodynamic circuit process device.

Abstract: Method of designing and producing a customer-specific component for clamping and/or gripping an object, in particular within the scope of an Internet-based access portal, having the following steps: providing CAD data of the object to be gripped and/or clamped by the user; generation of CAD data of the customer-specific component from the CAD data of a CAD blank of the customer-specific component and the CAD data of the object to be clamped and/or gripped such that the CAD data of the customer-specific component have, at least in sections, a negative surface of the object to be clamped and/or gripped; production of the customer-specific component using the CAD data of the customer-specific component by means of a generative production method.

Abstract: The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.

Abstract: The present invention provides a device which comprises: a heat exchanger (1) for transferring heat of a heat-supplying medium to a working medium which differs from said heat-supplying medium, a first supply device designed to provide a flow of the heat-supplying medium at a first temperature from a heat source to the heat exchanger, and a second supply device which is designed to deliver the heat-supplying medium after it has passed through the heat exchanger, and/or a further medium at a second temperature lower than the first temperature, to the flow of the heat-supplying medium at the first temperature.

Abstract: The present disclosure provides a retractor including an enclosure extending from a first open end to a second open end to form a lumen extending along an axis therebetween and that is accessible from the first open end and the second open end. The retractor further includes a first aperture formed at first angular position in the enclosure, and a second aperture formed at second angular position in the enclosure and opposing the first aperture to form a passage extending transverse to the axis from the first aperture, through the lumen, and to the second aperture. The first aperture and the second aperture are located proximate to the first open end and sized to arrange the passage along a spine of a patient to receive a trocar for delivering a graft material to the spine.

Abstract: The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.

Abstract: The present invention relates to polymer, homo- or copolymer or oligomer for the photoalignment of liquid crystals comprising a main chain and a side chain, wherein the side chain comprises a difluoromethylene group, compositions thereof, and its use for optical and electro optical devices, especially liquid crystal devices (LCDs).

Abstract: The invention relates to a gripping or clamping device for gripping or clamping objects, comprising at least one actuator that can be driven by a drive, at least one jaw, and a transmission provided between the actuator and the jaw, wherein the force produced by the drive is transmitted to the object at least by means of a force transmission element provided on or formed by the transmission and/or the clamping means, wherein the force transmission element has a force conducting section, wherein a clamping element that permits an elastic flexibility in the force transmission direction is provided between the force conducting section and the force transmission element.

Abstract: The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.

Abstract: A gripping or clamping device for gripping or clamping objects has at least one actuator that can be driven by a drive, at least one jaw, and a transmission provided between the actuator and the jaw, wherein the force produced by the drive is transmitted to the object at least by means of a force transmission element provided on or formed by the transmission and/or the clamping means, wherein the force transmission element has a force conducting section. A clamping element that permits an elastic flexibility in the force transmission direction is provided between the force conducting section and the force transmission element.

Abstract: The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.

Abstract: The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.

Abstract: The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.

Abstract: The present invention relates to a copolymer for the photoalignment of liquid crystals comprising a photoreactive group as given below in formula (I), compositions thereof, and its use for optical and electro optical devices, especially liquid crystal devices (LCDs).