Abstract: The present invention is concerned with materials and methods for mediating eukaryotic cell attachment to rigid surfaces. In particular, the invention is concerned with coatings for forming cell attachment surfaces, preferably for cell culture devices, microfluidic devices, biosensors or implants. The invention correspondingly provides polymer conjugates for such coatings, methods of polymer conjugate formation, methods of polymer conjugate application and uses of such polymer conjugates. The invention also provides surfaces and devices at least partly coated with such polymer conjugates.

Abstract: A device for locking a vehicle seat has a pawl which can be pivoted about a first pivot axis and, in a closed position, is in engagement with a positionally fixed fitting and, in an open position, is free from the fitting, wherein the pawl has a first clamping surface, furthermore a locking element for locking the pawl in the closed position, which locking element can be pivoted about a second pivot axis and has a second clamping surface which, in a locking position, bears against the first clamping surface and, in the process, keeps the pawl in the closed position, and, in an unlocking position, is free from the first clamping surface, and an actuating element which interacts with the locking element in order to transfer the locking element into the unlocking position.

Abstract: A growth factor delivery scaffold combines a heparin/fibrin-based delivery system (HBDS) with a backbone based on polymer nanofibers for tissue (e.g., tendon and ligament) repair. The scaffold has improved surgical handling properties compared to the gelatinous consistency of the prior art HBDS system and retains the capability for delivering mesenchymal cells and controlling the release of growth factors. One application for the scaffold is mesenchymal stem cell (MSC) therapy for flexor tendon repair. The scaffold can deliver growth factors in a sustained manner, can be implanted for flexor tendon repair, is biocompatible, and is not cytotoxic. The growth factor delivery scaffold may also be used in the surgical repair of an injury to bone, muscle, cartilage, or other tissues.

Abstract: A growth factor delivery scaffold combines a heparin/fibrin-based delivery system (HBDS) with a backbone based on polymer nanofibers for tissue (e.g., tendon and ligament) repair. The scaffold has improved surgical handling properties compared to the gelatinous consistency of the prior art HBDS system and retains the capability for delivering mesenchymal cells and controlling the release of growth factors. One application for the scaffold is mesenchymal stem cell (MSC) therapy for flexor tendon repair. The scaffold can deliver growth factors in a sustained manner, can be implanted for flexor tendon repair, is biocompatible, and is not cytotoxic. The growth factor delivery scaffold may also be used in the surgical repair of an injury to bone, muscle, cartilage, or other tissues.

Abstract: A growth factor delivery scaffold combines a heparin/fibrin-based delivery system (HBDS) with a backbone based on polymer nanofibers for tissue (e.g., tendon and ligament) repair. The scaffold has improved surgical handling properties compared to the gelatinous consistency of the prior art HBDS system and retains the capability for delivering mesenchymal cells and controlling the release of growth factors. One application for the scaffold is mesenchymal stem cell (MSC) therapy for flexor tendon repair. The scaffold can deliver growth factors in a sustained manner, can be implanted for flexor tendon repair, is biocompatible, and is not cytotoxic. The growth factor delivery scaffold may also be used in the surgical repair of an injury to bone, muscle, cartilage, or other tissues.

Abstract: The invention concerns a process for producing products of individual geometry, in particular dental prostheses or dental auxiliary parts, comprising the steps of producing a plurality of products on the surface of a substrate plate by means of selective hardening, in particular by means of selective sintering or melting, in which the material is applied in successive layers, after each layer application one or more predetermined regions of the applied layer is selectively hardened by means of an energy-rich radiation and connected to one or more regions of the subjacent layer, wherein the predetermined regions are predetermined on the basis of a cross-sectional geometry of the product in the respective layer. According to the invention the successive layers are applied in layer planes oriented inclinedly relative to the surface of the substrate plate. The invention further concerns an apparatus for carrying out such a process.

Abstract: A growth factor delivery scaffold combines a heparin/fibrin-based delivery system (HBDS) with a backbone based on polymer nanofibers for tissue (e.g., tendon and ligament) repair. The scaffold has improved surgical handling properties compared to the gelatinous consistency of the prior art HBDS system and retains the capability for delivering mesenchymal cells and controlling the release of growth factors. One application for the scaffold is mesenchymal stem cell (MSC) therapy for flexor tendon repair. The scaffold can deliver growth factors in a sustained manner, can be implanted for flexor tendon repair, is biocompatible, and is not cytotoxic. The growth factor delivery scaffold may also be used in the surgical repair of an injury to bone, muscle, cartilage, or other tissues.

Abstract: The invention concerns a process for producing products of individual geometry, in particular dental prostheses or dental auxiliary parts, comprising the steps of producing a plurality of products on the surface of a substrate plate by means of selective hardening, in particular by means of selective sintering or melting, in which the material is applied in successive layers, after each layer application one or more predetermined regions of the applied layer is selectively hardened by means of an energy-rich radiation and connected to one or more regions of the subjacent layer, wherein the predetermined regions are predetermined on the basis of a cross-sectional geometry of the product in the respective layer. According to the invention the successive layers are applied in layer planes oriented inclinedly relative to the surface of the substrate plate. The invention further concerns an apparatus for carrying out such a process.