Abstract: The present disclosure relates to a novel class of bifunctional molecules that are useful in a targeted or selective degradation of a protein.

Abstract: The invention provides for bifunctional molecules comprising an Rpn11 binding partner and a target protein binding partner. A bifunctional molecule according to the invention binds to Rpn11 and to the target protein, thereby facilitating degradation of the target protein bound to the target protein binding partner. The invention also provides for use of a bifunctional molecule for preventing or treating disease.

Abstract: Compounds having the general structure A-L-B are presented wherein A and B are independently an E3 ubiquitin ligase protein binding ligand compound of formula 1A or 1B. Pharmaceutical compositions comprising these compounds and methods of use are also presented.

Abstract: Systems and methods for authenticating a passive speaker include (i) activating, by a playback device configured to drive the passive speaker, a passive speaker identification circuit of the passive speaker by providing an identification signal to an input terminal of the passive speaker, wherein the passive speaker is a particular type of passive speaker having particular acoustic characteristics; (ii) while the passive speaker identification circuit is active, measuring, by the playback device, an electrical current of the identification signal; (iii) determining, based on the measured electrical current of the identification signal, an impedance modulation of the passive speaker; (iv) determining, by the playback device, the particular type of the passive speaker based on the impedance modulation of the passive speaker; and (v) applying, by the playback device, a calibration to the playback device based on the determined particular type of the passive speaker.

Abstract: Compounds having the general structure A-L-B are presented wherein A and B are independently an E3 ubiquitin ligase protein binding ligand compound of formula 1A or 1B. Pharmaceutical compositions comprising these compounds and methods of use are also presented.

Abstract: There is provided novel small molecule E3 ubiquitin ligase protein binding ligand compounds, and to their utility in PROteolysis Targeted Chimeras (PROTACs), as well as processes for their preparation thereof, and use in medicine. There is particularly provided novel small molecule E3 ubiquitin ligase protein binding inhibitor compounds based on a fluorohydroxyproline scaffold, to their utility as ligands in synthesizing novel PROTACs, and to synthetic methods therefor.

Abstract: Systems and methods for authenticating a passive speaker include (i) activating, by a playback device configured to drive the passive speaker, a passive speaker identification circuit of the passive speaker by providing an identification signal to an input terminal of the passive speaker, wherein the passive speaker is a particular type of passive speaker having particular characteristics; (ii) while the passive speaker identification circuit is active, measuring, by the playback device, an electrical current of the identification signal; (iii) determining, based on the measured electrical current of the identification signal, an impedance modulation of the passive speaker; (iv) determining, by the playback device, the particular type of the passive speaker based on the impedance modulation of the passive speaker; and (v) applying, by the playback device, a calibration to the playback device based on the determined particular type of the passive speaker.

Abstract: The invention provides for bifunctional molecules comprising an UchL5 binding partner and a target protein binding partner linked via a flexible linker. A bifunctional molecule according to the invention binds to UchL5 and to the target protein, thereby facilitating degradation of the target protein bound to the target protein binding partner. The invention also provides for use of a bifunctional molecule for preventing or treating disease.

Abstract: The invention provides for bifunctional molecules comprising an Rpn11 binding partner and a target protein binding partner. A bifunctional molecule according to the invention binds to Rpn11 and to the target protein, thereby facilitating degradation of the target protein bound to the target protein binding partner. The invention also provides for use of a bifunctional molecule for preventing or treating disease.

Abstract: Compounds having the general structure A-L-B are presented wherein A and B are independently an E3 ubiquitin ligase protein binding ligand compound of formula 1A or 1B. Pharmaceutical compositions comprising these compounds and methods of use are also presented.

Abstract: Safety device (1) for holding and sharing among a plurality of users a key (100) provided with a remote control (102). The safety device (1) includes: an external housing (2) adapted to internally contain said key (100), configurable according to an open configuration and a closed configuration; a lock (5) that can be commanded for switching between a closed status, that prevents said external housing (2) in the closed configuration from switching into the open configuration, and an open status, that enables the external housing (2) to switch between the open and the closed configurations; means for interacting with said remote control (102) of the key (100); a transmission unit (18) configured to receive, directly or via an external server (107), command signals from an external command device (19); and a command and control unit (17).

Abstract: Safety device (1) for holding and sharing among a plurality of users a key (100) provided with a remote control (102). The safety device (1) includes: an external housing (2) adapted to internally contain said key (100), configurable according to an open configuration and a closed configuration; a lock (5) that can be commanded for switching between a closed status, that prevents said external housing (2) in the closed configuration from switching into the open configuration, and an open status, that enables the external housing (2) to switch between the open and the closed configurations; means for interacting with said remote control (102) of the key (100); a transmission unit (18) configured to receive, directly or via an external server (107), command signals from an external command device (19); and a command and control unit (17).

Abstract: Systems and methods for authenticating a passive speaker include (i) activating, by a playback device configured to drive the passive speaker, a passive speaker identification circuit of the passive speaker by providing an identification signal to an input terminal of the passive speaker, wherein the passive speaker is a particular type of passive speaker having particular characteristics; (ii) while the passive speaker identification circuit is active, measuring, by the playback device, an electrical current of the identification signal; (iii) determining, based on the measured electrical current of the identification signal, an impedance modulation of the passive speaker; (iv) determining, by the playback device, the particular type of the passive speaker based on the impedance modulation of the passive speaker; and (v) applying, by the playback device, a calibration to the playback device based on the determined particular type of the passive speaker.

Abstract: There is provided novel small molecule E3 ubiquitin ligase protein binding ligand compounds, and to their utility in PROteolysis Targeted Chimeras (PROTACs), as well as processes for their preparation thereof, and use in medicine. There is particularly provided novel small molecule E3 ubiquitin ligase protein binding inhibitor compounds based on a fluorohydroxyproline scaffold, to their utility as ligands in synthesizing novel PROTACs, and to synthetic methods therefor.

Abstract: A motor vehicle driving style estimating system comprises: a measuring apparatus of a motion quantity of the motor vehicle; a processing apparatus connected to the measuring apparatus and configured to: define a value of a space corresponding to a measuring path; calculate, based on the motion quantity, an estimate of an energy consumed by the motor vehicle along the measuring path; calculate a reference energy associated to a reference behavior of the motor vehicle along the measuring path; and calculate an indication of the driving style dependent on: a difference between the consumed energy and reference energy, and on the space value.