Abstract: A universally usable electronic manual stamping device has an inkjet print head that can be moved back and forth in a print window, the print window being arranged in a base plate facing toward a print medium during the printing. A control unit of the device is connected with a user interface, with an external interface and with an internal interface. The inkjet print head is operationally connected via the internal interface with an actuator to move the inkjet print head and with an internal power source to supply the control unit, the inkjet print head and its actuator, as well as the interfaces. The control unit includes a security processor that possesses at least one transaction module which is provided to implement cryptographic security and certification tasks in connection with the printing of an individually secured stamp imprint.

Abstract: A procedure for checking the functionality of a reducing agent pump (172) of a NOx-reduction system of a combustion engine (110) is thereby characterized, in that it is checked, whether the pump (172) reaches a default engine speed value in a defined time interval within defined limits.

Abstract: A method and circuits for monitoring and detecting an error in the static pervasive signals applied to input/output pins of an integrated circuit during functional operation of the integrated circuit. The method and circuits provide a signal signature of each of one or more groups of the static pervasive signals and then monitoring the signal signature for any change of logic level.

Abstract: The invention relates to a pharmaceutical composition made from an active ingredient included in liposomes for topical application, whereby the liposomes have an aqueous medium in the interior thereof and contain at least one active ingredient therein which exerts a direct or indirect relaxing effect on smooth musculature and is preferably selected from the group of prostaglandins, adenylate cyclases, cAMP, AMP, ATP, NO-synthetases, nitrogen monoxide (NO), NO compounds, nitrates, guanylate cyclases, cGMP, GMP, GTP and phosphodiesterases, in particular, Sildenafil. The invention further relates to a method for production of said composition, optionally, in sterile form and the use of the liposomes supporting the active ingredient in various galenic forms for external application in the genital region, for prophylaxis and/or therapy of sexual disorders in men or women and/or for increase of sexual sensitivity.

Abstract: A procedure for a reasonability check of the signal of a temperature sensor that is arranged in a reducing tank, in particular a HWL-tank, is thereby characterized, in that the tank level is detected by a tank level sensor that is arranged almost at the same filling level position as the temperature sensor, in that the tank level sensor signal is compared to the temperature sensor signal and then, if default tank level sensor signals correlate within default limits with default temperature sensor signal values, a functioning temperature sensor and/or a functioning tank level sensor are indicated.

Abstract: A method for designing a circuit. The method includes (i) providing a netlist of a design and (ii) dividing the netlist into N user logics, N being a positive integer. After said dividing the netlist is performed, the N user logics in N macro test wrappers are instantiated resulting in N instantiated logics. After said instantiating the N user logics is performed, the N instantiated logics are processed. After said processing is performed, a result of said processing is back-annotated to the netlist.

Abstract: The present invention relates to biguanide-containing liposomes and antiseptic preparations based on biguanide-containing liposomes, where the liposomes are characterised in that they are essentially free of lipids with anionic head groups, to the preparation of biguanide-containing liposomes and of the antiseptic preparations, and to their possible uses and to the products arising from their use, in particular wound dressings.

Abstract: The present invention relates to liposomes for drug delivery, wherein a liposome includes molecules of at least one desired drug distributed within an aqueous phase in the interior of the liposome and wherein the liposome further includes molecules of the same or of another drug attached to either or both sides of the liposomal membrane. More specifically, the invention relates to liposomes, wherein at least a part of the molecules of a desired drug bear a functional group that is reactive with a functional group present in at least one lipid fraction, and wherein the drug is covalently linked to the membrane lipids by chemical bonding, e.g. by ester bonding of a hydroxyl group of a lipid molecule and an acidic residue of the drug. In a preferred embodiment, the desired drug is a glycoprotein such as erythropoietin. The invention further relates to a method of manufacture of said liposomes and to pharmaceutical compositions containing them.

Abstract: A device for defining participants in a control system that controls a printing machine is provided. The control system includes a central computer and a number of participants which interact with the central computer in order to carry out processes. The participants are connected to one another via lines of a bus system. The lines of the bus system and the participants have respective plugs for connecting the lines of the bus system to the participants. The plugs of the lines of the bus system have reserved plug contacts which are provided with one or more galvanic links for defining the respective participants.

Abstract: A process by which low viscosities liquids are filled into syringes without gas bubbles utilizing lowered temperature and valves to isolate the filling system from the vacuum. The liquid may be drug, device, pharmaceutical, and/or biotech products.

Abstract: The invention relates to a pharmaceutical composition based on an active ingredient that is enclosed in liposomes for topical, transdermal application. The interior of said liposomes comprises an acidic, aqueous medium containing at least one cholinesterase inhibitor, preferably from the group containing donepezil, rivastigmine, galantamine, physostigmine, heptylphysostigmine, phenserine, tolserine, cymserine, thiatolserine, thiacymserine, neostigmine, huperzine, tacrine, metrifonate and dichlorvos, or an enantiomer or derivative of at least one of said compounds. In addition, the invention relates to a method for producing said composition, optionally in a sterile form and also to the use of the liposomes charged with the active ingredient in various galenic formulations for topical, transdermal application with a depot effect in the epidermis, for the prophylaxis and/or treatment of cutaneous neuropathic pain or the loss of cutaneous sensory function as a result of neuropathy.

Abstract: The present invention relates to system clocking in computer systems. In particular, it relates to system clocking in high-end multi-processor, multi-node server computer systems with an enhanced degree of performance and reliability and to a method for dynamically switching between a first and a second clock signal, if the first should fail. More redundancy even to the Dynamic Clock Switching Circuit (DCSC) (14) and the wiring (17) from there to multiple, PLL-(12) free clock chips (22) is provided. Instead of only one DCSC (14) and one single wiring (17), two of them (14-0, 14-1; 17-0, 17-1) are used combined with a further particular logic present on each clock chip (22), which in combination generate two synchronous, fine-tuned, minimum-shifted clock signals and select always the first of them to arrive at a FlipFlop controlling the output for clock distribution wiring.

Abstract: A method for diagnosing an engine control unit (4) conducts an analysis as to whether the signal values from the cylinder pressure sensors (3) are faulty based on at least one characteristic value which is derived from an evaluation of signal values from the cylinder pressure sensors (3) of the cylinders (2) in a combustion engine (5). In addition to this is described the engine control unit (4) designed to execute the method. Also hereby disclosed is a method which, based on symmetrical aspects, determines a crankshaft angle (phipCylMaxTDC) for a cylinder pressure maximum during push mode operation of the combustion engine (5).

Abstract: A process and method by which low viscosities liquids are filled into syringes without gas bubbles utilizing lowered temperature and valves to isolate the filling system from the vacuum. The liquid may be drug, device, pharmaceutical, and/or biotech products.

Abstract: A process and method by which low viscosities liquids are filled into syringes without gas bubbles utilizing lowered temperature and valves to isolate the filling system from the vacuum. The liquid may be drug, device, pharmaceutical, and/or biotech products.

Abstract: The present invention relates to decoy oligonucleotides with the nucleic acid sequence according to SEQ ID NO: 1 to 36 and their use as pharmaceutical agents.

Abstract: The present invention relates to a pharmaceutical formulation for the funnelling of nucleic acids into eukaryotic cells, characterised in that the formulation has a pH-value within the range of pH 6.0 to pH 7.4, and/or an anion concentration within the range from 5 to 100 mmol/l and/or provides nonsteroidal anti-inflammatory drugs with a concentration within the range from 10 to 500 ?mol/l.

Abstract: A system and method for reconstructing pathways in large genetic networks from genetic perturbations comprises an analysis method and system that applies a recursive algorithm for determining the path between every gene pair in an arbitrarily large genetic network from large-scale gene perturbation data and reconstructs all direct and indirect regulatory gene interactions in the network. Graph theory mathematics is applied to genetic network reconstruction in the following manner: Genetic perturbation data is used to identify all genes accessible from a perturbed gene to generate an accessibility list for the gene. Graph theory mathematics is applied to the accessibility list and its graph to determine a condensation of the graph as defined by the condensation's accessibility list. Graph theory mathematics is applied to the accessibility list, such as through a recursive algorithm performed on a desktop computer, to obtain an adjacency list for the gene that characterizes a genetic network.

Abstract: The present invention relates to system clocking in computer systems. In particular, it relates to system clocking in high-end multi-processor, multi-node server computer systems with an enhanced degree of performance and reliability and to a method for dynamically switching between a first and a second clock signal, if the first should fail. More redundancy even to the Dynamic Clock Switching Circuit (DCSC) (14) and the wiring (17) from there to multiple, PLL-(12) free clock chips (22) is provided. Instead of only one DCSC (14) and one single wiring (17), two of them (14-0, 14-1; 17-0, 17-1) are used combined with a further particular logic present on each clock chip (22), which in combination generate two synchronous, fine-tuned, minimum-shifted clock signals and select always the first of them to arrive at a FlipFlop controlling the output for clock distribution wiring.

Abstract: A method for diagnosing an engine control unit (4) conducts an analysis as to whether the signal values from the cylinder pressure sensors (3) are faulty based on at least one characteristic value which is derived from an evaluation of signal values from the cylinder pressure sensors (3) of the cylinders (2) in a combustion engine (5). In addition to this is described the engine control unit (4) designed to execute the method. Also hereby disclosed is a method which, based on symmetrical aspects, determines a crankshaft angle (phipCylMaxTDC) for a cylinder pressure maximum during push mode operation of the combustion engine (5).