Abstract: A technique of renal denervation comprising methods and devices for generating one or more bubbles to at least partially fragment a calcification of a calcified region of a renal artery and for ablating one or more nerves about, within, or surrounding the calcified region of the renal artery after the calcification has been at least partially fragmented. Other embodiments are described and claimed.

Abstract: Features relating to a vaporizer body are provided. The vaporizer body may include an outer shell that includes an inner region defined by an outer shell sidewall. A support structure is configured to fit within the inner region of the outer shell. The support structure includes a storage region defined by a top support structure, a bottom support structure, a bottom cap, and a gasket. An integrated board assembly is configured to fit within the storage region of the support structure. The integrated board assembly may include a printed circuit board assembly formed of multiple layers that form a rigid structure and that include an inner, flexible layer. A first antenna is integrated at a proximal end of the flexible layer, and a second antenna is integrated at a distal end of the flexible layer.

Abstract: It relates to a pharmaceutical combination comprising a KRAS G12C inhibitor, in particular 1-{6-[(4M)-4-(5-Chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro [3.3] heptan-2-yl} prop-2-en-1-one (Compound A) and one or more therapeutically active agents selected from a SHP2 inhibitor (e.g. TNO155) and a PD-1 inhibitor, pharmaceutical compositions comprising the same; and methods of using such combinations and compositions in the treatment or prevention of a cancer or a tumor, in particular wherein the cancer or tumor is KRAS G12C mutated.

Abstract: The present application relates to an aluminum alloy, in particular a cast aluminum alloy, a method for producing an engine component, in particular a piston for an internal combustion engine, in which an aluminum alloy is cast using the gravity die casting method, and an engine component, in particular a piston for an internal combustion engine, consisting at least partially of an aluminum alloy. The aluminum alloy consists of the following alloy elements: silicon: 10% by weight to <13% by weight, nickel: up to <0.6% by weight, copper: 1.5% by weight to <3.6% by weight, magnesium: 0.5% by weight to 1.5% by weight, iron: 0.1% by weight to 0.7% by weight, manganese: 0.1 to 0.4% by weight, zirconium: >0.1 to <0.3% by weight, vanadium: >0.08 to <0.2% by weight, titanium: 0.05 to <0.2% by weight, phosphorus: 0.0025 to 0.008% by weight, and the remainder being aluminum and unavoidable impurities. Furthermore, the microstructure of the alloy has spheroidized primary precipitates.

Abstract: The invention provided herein provides dosage and dosage regimens for N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine (Compound (1)), or a pharmaceutically acceptable salt thereof, Compound (1) for the treatment of PRC2-mediated diseases or disorders. In addition, the invention provides using such dosage and dosage regimens in methods for treating PRC2-mediated diseases or disorders.

Abstract: An ultraviolet light-resistant article that includes: a substrate having a glass or glass-ceramic composition and first and second primary surfaces; an ultraviolet light-absorbing element having a an absorptivity greater than 50% at wavelengths from about 100 nm to about 380 nm and a thickness between about 10 nm and about 100 nm; and a dielectric stack formed with a plasma-enhanced process. Further, the light-absorbing element is between the substrate and the dielectric stack. Alternatively, the light-absorbing element can include one or more ultraviolet light-resistant layers disposed within the dielectric stack over the first primary surface.

Abstract: The present invention relates to methods for identifying multidrug combinations useful in the treatment of cancers, in particular solid tumor cancers and optimized multidrug combinations resulting therefrom. In particular, the invention relates to compositions useful in the treatment of cancer, in particular in the inhibition of spindle pole clustering in cancer cells.

Abstract: A method for starting-up a device with an embedded multimedia card (eMMC) is provided. The method comprises providing power to the device, putting the eMMC in a Fast-Boot modus, reading a bootloader from the eMMC into a RAM of the device, starting the bootloader in a CPU of the device, terminating the Fast-Boot modus, resetting the eMMC, putting the eMMC in the Fast-Boot modus initializing hardware by the bootloader, while reading an operating system into the RAM using DMA, and starting the operating system from the RAM by the bootloader is provided. A device comprising an embedded eMMC is also disclosed.

Abstract: The invention relates to a method for producing an indexable insert comprising the following steps: a) providing a starting material for use in an additive manufacturing method in several layers of material; and b) bonding each layer of the starting material in the form of an indexable insert.

Abstract: The present invention relates to a pharmaceutical combination comprising an FGFR4 inhibitor and a bile acid sequestrant, to the use of the pharmaceutical combination in the treatment of cancer, to the use of a bile acid sequestrant to reduce or mitigate side-effects associated with FGFR4 inhibition therapy.

Abstract: A rotary drive device has a fluid-actuated rotary drive with a drive housing and a drive unit which is rotative relative thereto. The drive unit includes a drive shaft and a pivot piston, non-rotatably arranged thereon, separating two drive chambers from one another. For controlling the fluid-actuated rotary drive, a control valve arrangement including at least one electrically actuatable control valve is provided, which is attached to the drive housing and in this way is combined with the rotary drive to form a drive assembly that can be handled as a single unit. Furthermore, a robot arm is proposed, which has the rotary drive device as an arm joint connecting two arm members.

Abstract: A glass article with a length equal to or greater than about 880 mm, a width orthogonal to the length equal to or greater than about 680 mm and a thickness T defined between first and second major surfaces is described. A total thickness variation TTV across the width of the glass article equal to or less than about 4 ?m. A maximum sliding interval range MSIR obtained from a predetermined interval moved in 5 mm increments across a width of the glass article is equal to or less than about 4 ?m. A method of making the glass article, and an apparatus therefor are also disclosed.

Abstract: The present invention relates to a pharmaceutical combination comprising an FGFR4 inhibitor and a bile acid sequestrant, to the use of the pharmaceutical combination in the treatment of cancer, to the use of a bile acid sequestrant to reduce or mitigate side-effects associated with FGFR4 inhibition therapy.

Abstract: An ultraviolet light-resistant article that includes: a substrate having a glass or glass-ceramic composition and first and second primary surfaces; an ultraviolet light-absorbing element having a an absorptivity greater than 50% at wavelengths from about 100 nm to about 380 nm and a thickness between about 10 nm and about 100 nm; and a dielectric stack formed with a plasma-enhanced process. Further, the light-absorbing element is between the substrate and the dielectric stack. Alternatively, the light-absorbing element can include one or more ultraviolet light-resistant layers disposed within the dielectric stack over the first primary surface.

Abstract: An ultraviolet light-resistant article that includes: a substrate having a glass or glass-ceramic composition and first and second primary surfaces; an ultraviolet light-absorbing element having a an absorptivity greater than 50% at wavelengths from about 100 nm to about 380 nm and a thickness between about 10 nm and about 100 nm; and a dielectric stack formed with a plasma-enhanced process. Further, the light-absorbing element is between the substrate and the dielectric stack. Alternatively, the light-absorbing element can include one or more ultraviolet light-resistant layers disposed within the dielectric stack over the first primary surface.

Abstract: The present invention relates to therapeutic uses of compounds of formula (I) or a pharmaceutically acceptable salt thereof

Abstract: A glass article with a length equal to or greater than about 880 mm, a width orthogonal to the length equal to or greater than about 680 mm and a thickness T defined between first and second major surfaces is described. A total thickness variation TTV across the width of the glass article equal to or less than about 4 m. A maximum sliding interval range MSIR obtained from a predetermined interval moved in 5 mm increments across a width of the glass article is equal to or less than about 4 m. A method of making the glass article, and an apparatus therefor are also disclosed.

Abstract: A rotary drive device has a fluid-actuated rotary drive with a drive housing and a drive unit which is rotative relative thereto. The drive unit includes a drive shaft and a pivot piston, non-rotatably arranged thereon, separating two drive chambers from one another. For controlling the fluid-actuated rotary drive, a control valve arrangement including at least one electrically actuatable control valve is provided, which is attached to the drive housing and in this way is combined with the rotary drive to form a drive assembly that can be handled as a single unit. Furthermore, a robot arm is proposed, which has the rotary drive device as an arm joint connecting two arm members.

Abstract: The present invention relates to therapeutic uses of compounds of formula (I) or a pharmaceutically acceptable salt thereof

Abstract: A pneumatic brake booster in which, for improving the sealing and simplifying the assembly of sealing elements, it is proposed that the booster housing in the bearing region of at least one sealing element has a metal coating having a surface roughness Ra>1.2.