Abstract: A test device (10) for testing a sample liquid with a test stripe (60), comprising the test stripe (60) comprising a backing (62) and an analytical membrane (64) in the centre portion of the backing, a housing comprising a housing base (20) and a housing lid (40), which are connected with each other, the housing base (20) comprises an accommodation portion (22) for accommodating the test stripe (60), the accommodation portion (22) comprises restricting elements (24) that restrict the movement of the test stripe (60) in y-direction, and the housing lid (40) comprises an inlet opening (42) for introducing the sample liquid into the housing, wherein the inlet opening (42) is located opposite to the accommodation portion (22), wherein the accommodation portion (22) of the housing base further comprises a plurality of lower bridges (26) on pre-defined positions for supporting the test stripe (60) and the housing lid (40) comprises a plurality of upper bridges (48) on pre-defined positions opposite to the accommoda

Abstract: The invention is related to an analytical chip for the simultaneous determination of one or more different bacterial 16S-rRNA in a liquid sample comprising—an evanescent field measurement platform, e.g. an optical waveguide, as a solid carrier and—a plurality of specific recognition elements immobilized in discrete measurement areas of known location forming an array of measurement areas on said evanescent field measurement platform, wherein—a multitude (i.e. 2 or more) of different specific recognition elements is immobilized in discrete measurement areas for the recognition and detection of each different 16S-rRNA, different recognition elements being specific for different subsequences of the 16S-rRNA to be detected, which are not directly adjacent and not overlapping in the sequence of said 16S-rRNA, and—said analytical chip is operable for the detection of 16S-rRNA in the evanescent field of the evanescent field measurement platform, without an amplification (e.g.

Abstract: A method of detecting a target polynucleotide using a solution phase nucleic acid sandwich assay, wherein the solid support is an optical planar waveguide, and the label is detected by measuring the luminescence that is excited in the evanescent field of the waveguide-A fully automated system may be used. The method may be of use in detecting nucleic acids associated with disease at very low concentrations.

Abstract: The invention relates to a surface for the immobilization of one or several first nucleic acids as recognition elements (“immobilization surface”), for the production of a recognition surface for the detection of one or several second nucleic acids in one or more samples which are brought into contact with the recognition surface, the first nucleic acids being applied to a layer of the graft copolymer poly(L-lysine)-g-poly(ethyleneglycol) (PLL-g-PEG) as surface for immobilization, characterized in that the grafting ratio g, in other words the ratio between the number of lysine units and the number of polyethylene glycol side chains (“PEG” side chains) has an average value between 7 and 13.