Abstract: The present invention relates to novel anti-FLT3 antibodies for specifically targeting extracellular domain of FLT3. The present invention further relates to targeting FLT3 by novel antibody-drug-conjugates (ADCs) based on the novel anti-FLT3 antibodies of the present invention, especially in combination with kinase inhibitors, for use in therapy and/or for use in a method of cancer treatment (e.g., acute myeloid leukemia (AML) with or without internal tandem duplication (ITD) mutations in the FLT3 gene (FLT3-ITD)).

Abstract: The invention relates to a method for stabilizing a diode laser with a semiconductor laser diode and an external resonator (ECDL), wherein the external resonator is comprised of at least one angle-dispersive, frequency-selective element and wherein the frequency of the diode laser is essentially determined by the length of the external resonator and by the position of the angle-dispersive, frequency-selective element, and wherein these two frequency-selective elements or one element thereof can be detuned by way of a correction means (10) for harmonization to each other, which is characterized in that the portion of the light reflected from the external resonator with the angle-dispersive, frequency-selective element back to the semiconductor laser diode and not optically coupled into the semiconductor laser diode (designated as “non-optically coupled light”) or part thereof, is measured and that from the relevant measuring values, after comparison with a reference value, a fault signal is generated which as

Abstract: The invention relates to a method for stabilizing a diode laser with a semiconductor laser diode and an external resonator (ECDL), wherein the external resonator is comprised of at least one angle-dispersive, frequency-selective element and wherein the frequency of the diode laser is essentially determined by the length of the external resonator and by the position of the angle-dispersive, frequency-selective element, and wherein these two frequency-selective elements or one element thereof can be detuned by way of a correction means (10) for harmonization to each other, which is characterized in that the portion of the light reflected from the external resonator with the angle-dispersive, frequency-selective element back to the semiconductor laser diode and not optically coupled into the semiconductor laser diode (designated as “non-optically coupled light”) or part thereof, is measured and that from the relevant measuring values, after comparison with a reference value, a fault signal is generated which as